Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Greg O'Connor"'
Autor:
Gillian A Hawker, Eric Bohm, James Stewart, Deborah A Marshall, Raj Sharma, Jason Werle, Peter Faris, Linda J Woodhouse, Bheeshma Ravi, Paul Duffy, Shannon Puloski, Kelly Johnston, Greg Abelseth, Raul Kuchinad, Tom Noseworthy, John Donaghy, C Allyson Jones, James Powell, Ian Stanaitis, Michael J Dunbar, Gillian A. Hawker, Deborah A. Marshall, Michael J. Dunbar, C. Allyson Jones, Linda J. Woodhouse, Gordon Arnett, Robert Balyk, Jeffery Bury, John Cinats, Donald Dick, D'Arcy Durand, Lee Ekert, Robert Glasgow, Don Glasgow, Gordon Goplen, Catherine Hui, Ben Herman, Larry Hunka, Hongxing Jiang, William C. Johnson, Frank Kortbeek, Guy Lavoie, Mitch Lavoie, Paul K. Leung, James Mahood, Edward Masson, Richard McLeod, James McMillan, Greg O’Connor, David Otto, Carlo Panaro, Paulose Paul, Gordon Russell, Colleen Weeks, Don Weber, Andrea Woo, Jane Squire Howden, Anne-Marie Adachi, Jessica Beatty, Shakib Rahman, Kelley De Souza, Robert Korley, Michael Monument, Maureen O'Brien, Ed Rendall, Alex Rezansoff, Scott Timmerman, Tanya Reczek, Jeffrey Depew, Bukky Dada
Publikováno v:
RMD Open, Vol 9, Iss 2 (2023)
Objectives One-fifth of total knee arthroplasty (TKA) recipients experience a suboptimal outcome. Incorporation of patients’ preferences in TKA assessment may improve outcomes. We determined the discriminant ability of preoperative measures of TKA
Externí odkaz:
https://doaj.org/article/ec9d695506824cab8e9dde2cd32400c8
Autor:
Hailei Su, Christos Christodoulatos, Benjamin Smolinski, Per Arienti, Greg O'Connor, Xiaoguang Meng
Publikováno v:
Engineering, Vol 5, Iss 5, Pp 849-854 (2019)
2,4-Dinitroanisole (DNAN) is an important component of insensitive munitions that is anticipated to replace 2,4,6-trinitrotoluene (TNT) in munitions formulations. Photocatalyzed hydrogen peroxide (H2O2) oxidation experiments and chemical analyses wer
Externí odkaz:
https://doaj.org/article/a9d2c66bbf5342908f13d55f52ad91e4
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
Supplementary Figure 1. AZD5153 shows reduced BRD4 binding activity when BD2 function is abolished; Supplementary Figure 2. AZD5153 modulates MYC protein levels across hematologic cancer cell lines; Supplementary Figure 3. Gene Ontology (GO) analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a3fc1c9e0ac7cc5baf19a1c1e82cb3
https://doi.org/10.1158/1535-7163.22506301
https://doi.org/10.1158/1535-7163.22506301
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
Protein modulation by AZD5153 in hematological cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95847a4372d50fae63c38140fe63041
https://doi.org/10.1158/1535-7163.22506292.v1
https://doi.org/10.1158/1535-7163.22506292.v1
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
Cell line authentication information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff0443ca83bc32e2d5b91ded374d6cf
https://doi.org/10.1158/1535-7163.22506298.v1
https://doi.org/10.1158/1535-7163.22506298.v1
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
The bromodomain and extraterminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Pharmacological targeting of BRD4 bromodomains by small molecule inhibitors has proven to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491aac7aed6ce358594bc45ec314c59a
https://doi.org/10.1158/1535-7163.c.6538351.v1
https://doi.org/10.1158/1535-7163.c.6538351.v1
Autor:
Huawei Chen, Edwin Clark, Michael Zinda, Michael J. Waring, Stephen E. Fawell, Gordon B. Mills, Paul Lyne, Corinne Reimer, Jonathan R. Dry, Alfred A. Rabow, Tammie C. Yeh, Greg O'Connor, Graeme Walker, Miika J. Ahdesmaki, Larry Bao, Michael Collins, Deborah Lawson, Lillian Castriotta, Shenghua Wen, Jingwen Zhang, Tony Cheung, Scott Boiko, Ian L. Dale, Philip Petteruti, Wenxian Wang, Austin Dulak, Yi Yao, Maureen M. Hattersley, Garrett W. Rhyasen
Differentially expressed genes with AZD5153 treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1840bcd6939c18a3d1c667350d651fff
https://doi.org/10.1158/1535-7163.22506295
https://doi.org/10.1158/1535-7163.22506295
Autor:
Huawei Chen, J. Carl Barrett, Maureen Hattersley, Austin Dulak, Philip Petteruti, Greg O'Connor, Tammie C. Yeh
Figure S1: Downregulation of CCR2, CD180, MYC and upregulation of HEXIM1 mRNAs by AZD5153 in cells can be detected at 4h; Figure S2: Other BRD4/BET compounds can also downregulate CCR2 and CD180 mRNAs in hematological tumor cell lines; Supplementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317d92c5b696a9e5ac20538f597c269d
https://doi.org/10.1158/1078-0432.22465697.v1
https://doi.org/10.1158/1078-0432.22465697.v1
Autor:
Kris Sachsenmeier, Johanna C. Bendell, Todd M. Bauer, J. Carl Barrett, Kelly Goodwin, Joshua Armenia, Deanna L. Russell, Melinda S. Merchant, Jonathan R. Dry, Manish R. Patel, Gerald Steven Falchook, Ben Sidders, Richard Woessner, Greg O'Connor, Pei Zhang, Robert McEwen, Gayle Pageau Pouliot, Alexandra Borodovsky, Bolan Linghu
Publikováno v:
Clinical Cancer Research. 26:2176-2187
Purpose:There are several agents in early clinical trials targeting components of the adenosine pathway including A2AR and CD73. The identification of cancers with a significant adenosine drive is critical to understand the potential for these molecu
Autor:
Christos Christodoulatos, Per Arienti, Hailei Su, Xiaoguang Meng, Greg O'Connor, Benjamin Smolinski
Publikováno v:
Engineering, Vol 5, Iss 5, Pp 849-854 (2019)
2,4-Dinitroanisole (DNAN) is an important component of insensitive munitions that is anticipated to replace 2,4,6-trinitrotoluene (TNT) in munitions formulations. Photocatalyzed hydrogen peroxide (H2O2) oxidation experiments and chemical analyses wer