Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Greg Morriello"'
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
Autor:
Blair T. Lapointe, Jack D. Scott, Xin Cindy Yan, Haiqun Tang, Janice D Woodhouse, Kaleen Konrad Childers, Robert Faltus, Erin F. DiMauro, Solomon Kattar, Charles S. Yeung, Ravi Kurukulasuriya, Vladimir Simov, Hakan Gunaydin, Anmol Gulati, Joey L. Methot, Rachel L. Palte, Ellen C. Minnihan, Greg Morriello, J. Michael Ellis, Harold B. Wood, Santhosh Neelamkavil, Karin M. Otte, Michael J. Ardolino, Barbara Pio, Ping Liu, Laxminarayan G Hegde, Matthew J. Fell, Vanessa L. Rada, Peter Fuller, Paul J Ciaccio
Publikováno v:
RSC Med Chem
The discovery of potent, kinome selective, brain penetrant LRRK2 inhibitors is the focus of extensive research seeking new, disease-modifying treatments for Parkinson's disease (PD). Herein, we describe the discovery and evolution of a picolinamide-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8d45ea7dd7adda70471298a4476afa
https://europepmc.org/articles/PMC8292993/
https://europepmc.org/articles/PMC8292993/
Autor:
Lihu Yang, Greg Morriello
Publikováno v:
Tetrahedron Letters. 40:8197-8200
A new approach to the synthesis of cyclic peptides using Kenner's ‘safety-catch’ sulfonamide linker is described. After the linear peptide is assembled by Fmoc peptide synthesis, trityl is adopted as a temporary protecting group for the N-terminu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c95201cfa4f7bb48cde69aed94d9c09
https://doi.org/10.1016/s0040-4039(99)01701-3
https://doi.org/10.1016/s0040-4039(99)01701-3
Autor:
Klaus D. Schleim, Roy G. Smith, Kristine Prendergast, Lihu Yang, Wanda Chan, Arthur A. Patchett, Greg Morriello, Thomas M. Jacks, Kang Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:107-112
Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3-piperidine) was found to afford secretago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e526be722ad4697c6cd111e90dddbc
https://doi.org/10.1016/s0960-894x(97)10199-8
https://doi.org/10.1016/s0960-894x(97)10199-8
Nipecotic and iso -nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists
Autor:
Kang Cheng, Yanping Pan, Liangqin Guo, Arthur A. Patchett, Tom Jacks, Changyou Zhou, Alex Pasternak, Lihu Yang, James M. Schaeffer, Greg Morriello, Klaus D. Schleim, Su-Er W. Huskey, Elizebeth T Birzin, Susan P. Rohrer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:415-417
N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the somatostatin subtype-2 receptor in vitro. For example iso-nipecotic amide 8a showed high hsst2 binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b60f3d2baa9e10828dc5b3aeb21cd38
https://doi.org/10.1016/s0960-894x(00)00687-9
https://doi.org/10.1016/s0960-894x(00)00687-9
Autor:
Kang Cheng, Roy G. Smith, Kristine Prendergast, Arthur A. Patchett, Klaus D. Schleim, Lihu Yang, Greg Morriello, Wanda Chan, Thomas M. Jacks
Publikováno v:
ChemInform. 29
Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3-piperidine) was found to afford secretago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0b4ee6a4c21d5f028151960111ce41
https://doi.org/10.1002/chin.199818151
https://doi.org/10.1002/chin.199818151
Autor:
Klaus D. Schleim, Tom Jacks, Lihu Yang, Kang Cheng, Greg Morriello, Kwan Leung, Roy G. Smith, Arthur A. Patchett
Publikováno v:
ChemInform. 30
Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e160a413a05d9adae6de7a6dbb39d997
https://doi.org/10.1002/chin.199943187
https://doi.org/10.1002/chin.199943187
Autor:
Kwan Leung, Lihu Yang, Roy G. Smith, Greg Morriello, Arthur A. Patchett, Kang Cheng, Shuet-Hing Lee Chiu, Klaus D. Schleim, Tom Jacks, William P. Feeney, Wanda W.-S. Chan
Publikováno v:
Journal of Medicinal Chemistry. 41:2439-2441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05ab80a618cb79699b1bda8eb2030d3
https://doi.org/10.1021/jm9800191
https://doi.org/10.1021/jm9800191
Autor:
Lihu Yang, Greg Morriello, Alexander Pasternak, James M. Schaeffer, Susan P. Rohrer, Liangqin Guo, Yanping Pan, Arthur A. Patchett
Publikováno v:
Peptides for the New Millennium ISBN: 0792364457
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71c2a996176fab0d779ccdbebd067cfd
https://doi.org/10.1007/0-306-46881-6_101
https://doi.org/10.1007/0-306-46881-6_101
Autor:
Kang Cheng, Arthur A. Patchett, Lihu Yang, Greg Morriello, Roy G. Smith, Kwan Leung, Klaus D. Schleim, Tom Jacks
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(13)
Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8e9aae99958c540d7f6ce1bb4b493d
https://pubmed.ncbi.nlm.nih.gov/10406638
https://pubmed.ncbi.nlm.nih.gov/10406638