Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Greg M. Allen"'
Autor:
Greg M. Allen, Nicholas W. Frankel, Nishith R. Reddy, Hersh K. Bhargava, Maia A. Yoshida, Sierra R. Stark, Megan Purl, Jungmin Lee, Jacqueline L. Yee, Wei Yu, Aileen W. Li, K. Christopher Garcia, Hana El-Samad, Kole T. Roybal, Matthew H. Spitzer, Wendell A. Lim
Publikováno v:
Science (New York, N.Y.), vol 378, iss 6625
Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with immunosuppressive microenvironments. To overcome suppression, we engineered circuits in which tumor-specific synNotch receptors locally induce production of the cytokin
Autor:
Greg M, Allen, Wendell A, Lim
Publikováno v:
Nature reviews. Cancer. 22(12)
In the past several decades, the development of cancer therapeutics has largely focused on precision targeting of single cancer-associated molecules. Despite great advances, such targeted therapies still show incomplete precision and the eventual dev
Autor:
Kole T. Roybal, Wendell A. Lim, Cristina Puig-Saus, Vivian P. Garcia, Greg M. Allen, Devan Shah, Antoni Ribas, Gavin E. Shavey, Jasper Z. Williams, Igal S. Sterin, Wei Yu, Jennifer Tsoi, Ki H. Kim
Publikováno v:
Science (New York, N.Y.), vol 370, iss 6520
Science
Science
A logic to cell-cell recognition There has been exciting progress in the field of cancer immunotherapy, which harnesses a patient's own immune system to kill cancer cells. However, achieving precise recognition of cancer cells remains challenging. Ce
Autor:
Cyrus A. Wilson, Alex Groisman, Alex Mogilner, Erin L. Barnhart, Kun Chun Lee, Julie A. Theriot, Greg M. Allen, Edgar Gutierrez, Mark A. Tsuchida
Publikováno v:
Cell Syst
SummaryMotile cells navigate complex environments by changing their direction of travel, generating left-right asymmetries in their mechanical subsystems to physically turn. Currently little is known about how external directional cues are propagated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6bcb5b2f8a8f2364cf79849151f3c8
https://europepmc.org/articles/PMC7530145/
https://europepmc.org/articles/PMC7530145/
Autor:
Greg M. Allen, Edgar Gutierrez, Alex Mogilner, Mark A. Tsuchida, Kun Chun Lee, Erin L. Barnhart, Cyrus A. Wilson, Julie A. Theriot, Alex Groisman
In this study, we explore a simulation of a mechanical model of the keratocyte lamellipodium as previously tested and calibrated for straight steady-state motility [1] and for the process of polarization and motility initiation [2]. In brief, this mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::646958be715b6e5686505db9c2ac1167
https://doi.org/10.1101/2020.06.03.132456
https://doi.org/10.1101/2020.06.03.132456
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(16)
Cells are dynamic systems capable of spontaneously switching among stable states. One striking example of this is spontaneous symmetry breaking and motility initiation in fish epithelial keratocytes. Although the biochemical and mechanical mechanisms
Autor:
Greg M. Allen, Zachary Pincus, Erin L. Barnhart, Julie A. Theriot, Alex Mogilner, Gerard Marriott, Kinneret Keren
Publikováno v:
Nature. 453(7194)
The shape of motile cells is determined by many dynamic processes spanning several orders of magnitude in space and time, from local polymerization of actin monomers at subsecond timescales to global, cell-scale geometry that may persist for hours. U
Autor:
Kinneret Keren, Greg M. Allen, Mark A. Tsuchida, Lin Ji, Patricia T. Yam, Erin L. Barnhart, Kathryn T. Applegate, Gaudenz Danuser, Julie A. Theriot, Cyrus A. Wilson
Publikováno v:
Nature
Crawling locomotion of eukaryotic cells is achieved by a process dependent on the actin cytoskeleton: protrusion of the leading edge requires assembly of a network of actin filaments, which must be disassembled at the cell rear for sustained motility
Publikováno v:
Current Biology. (7):560-568
SummaryBackgroundMotile cells exposed to an external direct current electric field will reorient and migrate along the direction of the electric potential in a process known as galvanotaxis. The underlying physical mechanism that allows a cell to sen