Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Greg M Delgoffe"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background Oncolytic viruses (OVs) are an attractive way to increase immune infiltration into an otherwise cold tumor. While OVs are engineered to selectively infect tumor cells, there is evidence that they can infect other non-malignant cells in the
Externí odkaz:
https://doaj.org/article/3e5dce664fb64004b4339f0027efe502
Autor:
Grace P Carreno-Florez, Brian R Kocak, Matthew R Hendricks, Jeffrey A Melvin, Katrina B Mar, Jessica Kosanovich, Rachel L Cumberland, Greg M Delgoffe, Sruti Shiva, Kerry M Empey, John W Schoggins, Jennifer M Bomberger
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011719 (2023)
Clinical studies report that viral infections promote acute or chronic bacterial infections at multiple host sites. These viral-bacterial co-infections are widely linked to more severe clinical outcomes. In experimental models in vitro and in vivo, v
Externí odkaz:
https://doaj.org/article/bc271073a1df4e65b1bf723cc4ded213
Autor:
Benjamin Boyerinas, Greg M Delgoffe, Yupeng Wang, Alok Kumar, Ashley V Menk, Konstantinos Lontos, Yiyang Wang, Jason Lohmueller, Supriya K Joshi, Andrew T Frisch, McLane J Watson, Rachel Cumberland, Esteban Carrizosa
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Cellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells. Chimeric antigen receptor (CAR) therapy involves genetic engineering to ‘redirect’
Externí odkaz:
https://doaj.org/article/fd472df9a6d743fab850b3a2c42e8947
Autor:
Greg M Delgoffe, Kristin DePeaux, Angen Liu, Dan P Zandberg, Ashley V Menk, Maria Velez, Daniel Normolle
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
The majority of patients with recurrent/metastatic squamous cell carcinoma of the head and neck (HNSCC) (R/M) do not benefit from anti-PD-1 therapy. Hypoxia induced immunosuppression may be a barrier to immunotherapy. Therefore, we examined the metab
Externí odkaz:
https://doaj.org/article/d0916971c66149a6a4ea79c16d0bb5d0
Autor:
Paolo A. Ascierto, Carlo Bifulco, Luigi Buonaguro, Leisha A. Emens, Robert L. Ferris, Bernard A. Fox, Greg M. Delgoffe, Jérôme Galon, Cesare Gridelli, Marco Merlano, Paul Nathan, Kunle Odunsi, Hideho Okada, Chrystal M. Paulos, Sandro Pignata, Kurt A. Schalper, Stefani Spranger, Giampaolo Tortora, Hassane Zarour, Lisa H. Butterfield, Igor Puzanov
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-20 (2019)
Abstract Immunotherapy is now widely established as a potent and effective treatment option across several types of cancer. However, there is increasing recognition that not all patients respond to immunotherapy, focusing attention on the immune cont
Externí odkaz:
https://doaj.org/article/521b648e5d4848b4b2defdca6c669e8b
Autor:
Paolo D. A. Vignali, Kristin DePeaux, McLane J. Watson, Chenxian Ye, B. Rhodes Ford, Konstantinos Lontos, Nicole K. McGaa, Nicole E. Scharping, Ashley V. Menk, Simon C. Robson, Amanda C. Poholek, Dayana B. Rivadeneira, Greg M. Delgoffe
Publikováno v:
Nature Immunology. 24:267-279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5b04dd1f0b003240dcd0422a4fb8079
https://doi.org/10.1038/s41590-022-01379-9
https://doi.org/10.1038/s41590-022-01379-9
Autor:
Shankar Revu, Jing Wu, Matthew Henkel, Natalie Rittenhouse, Ashley Menk, Greg M. Delgoffe, Amanda C. Poholek, Mandy J. McGeachy
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2642-2653 (2018)
Summary: Th17 cells drive autoimmune disease but also control commensal microbes. A common link among antigens from self-proteins or commensal microbiota is relatively low activation of T cell receptor (TCR) and costimulation signaling. Indeed, stron
Externí odkaz:
https://doaj.org/article/ccc4f882024b4e13883ca1100600cc92
Autor:
Ashley V. Menk, Nicole E. Scharping, Rebecca S. Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A. Young, Stacy Gelhaus Wendell, Greg M. Delgoffe
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1509-1521 (2018)
Summary: To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events
Externí odkaz:
https://doaj.org/article/9a323dcf2c784882a7635f4587454ea7
Autor:
Alicia R. Watson, Helong Dai, Yawen Zheng, Ryosuke Nakano, Anastasios D. Giannou, Ashley V. Menk, Donna B. Stolz, Greg M. Delgoffe, Angus W. Thomson
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved. Here, we d
Externí odkaz:
https://doaj.org/article/8d8baed11249439eb87f816f70d2d5fe
Autor:
Dana M. Previte, Christina P. Martins, Erin C. O’Connor, Meghan L. Marre, Gina M. Coudriet, Noah W. Beck, Ashley V. Menk, Rebecca H. Wright, Hubert M. Tse, Greg M. Delgoffe, Jon D. Piganelli
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 129-141.e4 (2019)
Summary: Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor expressed by CD4+ T cells and tempers their homeostatic expansion. Because CD4+ T cell proliferation is tightly coupled to bioenergetics, we investigate the role of LAG-3 in modu
Externí odkaz:
https://doaj.org/article/5973900a5fa04fefa8bb32117570e50d