Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Greg M Arndt"'
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer
Autor:
Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Marie Wong, Alvin Kamili, Maria Tsoli, Tim W Failes, Amit Kumar, Emily V A Mould, Andrew Gifford, Shu‐Oi Chow, Mark Pinese, Jamie I Fletcher, Greg M Arndt, Dong‐Anh Khuong‐Quang, Carol Wadham, Daniel Batey, Georgina Eden, Peter Trebilcock, Swapna Joshi, Stephanie Alfred, Anjana Gopalakrishnan, Aaminah Khan, Dylan Grebert Wade, Patrick A Strong, Elodie Manouvrier, Lisa T Morgan, Miriam Span, Jin Yi Lim, Roxanne Cadiz, Caitlin Ung, David M Thomas, Katherine M Tucker, Meera Warby, Geoffrey B McCowage, Luciano Dalla‐Pozza, Jennifer A Byrne, Federica Saletta, Andrew Fellowes, Stephen B Fox, Murray D Norris, Vanessa Tyrrell, Toby N Trahair, Richard B Lock, Mark J Cowley, Paul G Ekert, Michelle Haber, David S Ziegler, Glenn M Marshall
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp n/a-n/a (2022)
Abstract Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical responses and cure rates. We developed a precision medicine platform of rapid high‐throughput drug screening (HTS) and patient‐
Externí odkaz:
https://doaj.org/article/f2db646d5831450d847f4d18a36cdea2
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4758 (2009)
RNA-mediated gene silencing, in the form of RNA interference (RNAi) or microRNAs (miRNAs) has provided novel tools for gene discovery and validation in mammalian cells. Here, we report on the construction and application of a random small RNA express
Externí odkaz:
https://doaj.org/article/c25b793814974aa7b1448cf25239a6b5
Autor:
Jérémy Ariey-Bonnet, Raphael Berges, Marie-Pierre Montero, Baptiste Mouysset, Patricia Piris, Kevin Muller, Guillaume Pinna, Tim W. Failes, Greg M. Arndt, Philippe Morando, Nathalie Baeza-Kallee, Carole Colin, Olivier Chinot, Diane Braguer, Xavier Morelli, Nicolas André, Manon Carré, Emeline Tabouret, Dominique Figarella-Branger, Marion Le Grand, Eddy Pasquier
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104752- (2023)
Summary: Background: Pharmacological synergisms are an attractive anticancer strategy. However, with more than 5000 approved-drugs and compounds in clinical development, identifying synergistic treatments represents a major challenge. Methods: High-t
Externí odkaz:
https://doaj.org/article/4e5974d9a61641e8a0393d2342009fa9
Autor:
Simon Brayford, Alastair Duly, Wee Siang Teo, Tanya Dwarte, Estrella Gonzales‐Aloy, Zerong Ma, Laura McVeigh, Timothy W. Failes, Greg M. Arndt, Joshua A. McCarroll, Maria Kavallaris
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4455-4471 (2023)
Abstract Non‐Small Cell Lung Carcinoma (NSCLC) remains a leading cause of cancer death. Resistance to therapy is a significant problem, highlighting the need to find new ways of sensitising tumour cells to therapeutic agents. βIII‐tubulin is ass
Externí odkaz:
https://doaj.org/article/ca6480afb088470ca3e0c2a36817e4bf
Autor:
Lin Xiao, Mawar Karsa, Emma Ronca, Angelika Bongers, Angelika Kosciolek, Ali El-Ayoubi, Jezrael L. Revalde, Janith A. Seneviratne, Belamy B. Cheung, Laurence C. Cheung, Rishi S. Kotecha, Andrea Newbold, Stefan Bjelosevic, Greg M. Arndt, Richard B. Lock, Ricky W. Johnstone, Andrei V. Gudkov, Katerina V. Gurova, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Klaartje Somers
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome. Driven by the unmet need to develop better therapies for KMT2A-rearranged leuke
Externí odkaz:
https://doaj.org/article/030ef39db2a746f68cb7bcf2cf823422
Autor:
Jérémy Ariey-Bonnet, Raphael Berges, Marie-Pierre Montero, Baptiste Mouysset, Patricia Piris, Kevin Muller, Guillaume Pinna, Tim W. Failes, Greg M. Arndt, Nathalie Baeza-Kallee, Carole Colin, Olivier Chinot, Diane Braguer, Xavier Morelli, Nicolas André, Manon Carré, Emeline Tabouret, Dominique Figarella-Branger, Marion Le Grand, Eddy Pasquier
Synergistic drug combinations are an attractive anticancer strategy but prove challenging to identify. Here we present a stepwise approach consisting in revealing core cancer vulnerabilities and exploiting them through drug combination screen to unco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc0db2c096194661392b7b7cbe509ead
https://doi.org/10.1101/2022.12.14.520491
https://doi.org/10.1101/2022.12.14.520491
Autor:
Annatina S. Schnegg-Kaufmann, Julie A. I. Thoms, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma M. V. Johansson, Timothy W. Failes, Greg M. Arndt, Jason Koval, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J. Mead, Ashwin Unnikrishnan, Sarah Davidson, Mark N. Polizzotto, Mark Hertzberg, Elli Papaemmanuil, Stefan K. Bohlander, Omid R. Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Publikováno v:
Blood.
Myelodysplastic neoplasms (MDSs) and chronic myelomonocytic leukemia (CMML) are clonal disorders driven by progressively acquired somatic mutations in hematopoietic stem cells (HSCs). Hypomethylating agents (HMAs) can modify the clinical course of MD
Autor:
Simon Brayford, Alastair Duly, Wee Siang Teo, Tanya Dwarte, Estrella Gonzales‐Aloy, Zerong Ma, Laura McVeigh, Timothy W. Failes, Greg M. Arndt, Joshua A. McCarroll, Maria Kavallaris
Publikováno v:
Cancer medicineREFERENCES.
Non-Small Cell Lung Carcinoma (NSCLC) remains a leading cause of cancer death. Resistance to therapy is a significant problem, highlighting the need to find new ways of sensitising tumour cells to therapeutic agents. βIII-tubulin is associated with
Autor:
Jinhan Xie, Paulette Barahona, Michelle Haber, Emily Mould, Andrew J. Gifford, Loretta Lau, Amit Kumar, Timothy W. Failes, Marie Wong-Erasmus, Dylan Grebert-Wade, Greg M. Arndt, M. Emmy M. Dolman, Dong-Anh Khuong-Quang, Chelsea Mayoh, Kanika Bhatia, Shu-Oi Chow, Alvin Kamili, Roxanne Cadiz, Richard B. Lock, Maria Tsoli, Vanessa Tyrrell, David S. Ziegler, Glenn M. Marshall, Penny Athanasatos
Publikováno v:
Cancer Cytopathology. 129:805-818
Background The development of high-throughput drug screening (HTS) using primary cultures provides a promising, clinically translatable approach to tailoring treatment strategies for patients with cancer. However, this has been challenging for solid
Autor:
Greg M. Arndt, Marc R. Wilkins, Mark J. Raftery, Kathryn Evans, Julia W Bӧhm, Anna Mariana, Tim Failes, Ling Zhong, Michelle Haber, Ignatius Pang, Chelsea Mayoh, Richard B. Lock, Connor D. Jones, Glenn M. Marshall, Murray D. Norris, Stephen W. Erickson, Robert R. Landman, Keith C.S. Sia, Robert Collins
Publikováno v:
Leukemia. 35:3101-3112
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk ALL subtype with high rates of relapse and poor patient outcome. Activating mutations affecting components of the JAK-STAT signaling pathway occur in the majority