Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Greg L. McKie"'
Autor:
Hesham Shamshoum, Kyle D. Medak, Greg L. McKie, Stewart Jeromson, Margaret K. Hahn, David C. Wright
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115671- (2023)
Antipsychotic medications are used in the management of schizophrenia and a growing number of off-label conditions. While effective at reducing psychoses, these drugs possess noted metabolic side effects including weight gain, liver lipid accumulatio
Externí odkaz:
https://doaj.org/article/6de73a7a28604652ba7b642fa2ff7f7b
Autor:
Kyle D. Medak, Alyssa J. Weber, Hesham Shamshoum, Greg L. McKie, Margaret K. Hahn, David C. Wright
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of schizophrenia and several on- and off-label conditions. While effective in reducing psychoses, acute olanzapine treatment causes rapid hyperglycemia, insulin resistance, a
Externí odkaz:
https://doaj.org/article/0448274fd60e464b8b6683d703bc0b97
Publikováno v:
Physiological Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1)
Externí odkaz:
https://doaj.org/article/38b74cfed5e44708b9acc47e4a7d90dd
Autor:
Mitchel C. Whittal, Derek P. Zwambag, Luke W. Vanderheyden, Greg L. McKie, Tom J. Hazell, Diane E. Gregory
Publikováno v:
Frontiers in Sports and Active Living, Vol 2 (2020)
This study investigated weight distribution between the lower limbs using a symmetry index (SI) score of the vertical ground reaction forces (GRF) and measures of postural stability in high load/low repetition (termed “heavy”) and low load/high r
Externí odkaz:
https://doaj.org/article/482f740a585b413b97fb9f8fd9433425
Publikováno v:
Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020)
Abstract The liver is the primary metabolic organ involved in the endogenous production of glucose through glycogenolysis and gluconeogenesis. Hepatic glucose production (HGP) is increased via neural‐hormonal mechanisms such as increases in catecho
Externí odkaz:
https://doaj.org/article/bcc2faf8fb7742a18060a7e44ac5e08a
Publikováno v:
The Journal of Physiology. 600:2713-2728
Antipsychotic (AP) medications, such as olanzapine (OLZ), are used in the treatment of schizophrenia and a growing number of 'off-label' conditions. A single dose of OLZ causes robust increases in blood glucose within minutes of treatment. The purpos
Autor:
Hesham Shamshoum, Hana A. Dibe, Jibran Y. Khokhar, Greg L. McKie, David C. Wright, Hayley H. A. Thorpe, Christine A. Doucette, Kristin Hunt
Publikováno v:
The Journal of Physiology. 600:829-845
Key points Ambient cold exposure is often regarded as a promising anti-obesity treatment in mice. However, most preclinical studies aimed at treating obesity via cold-induced thermogenesis have been confounded by sub-thermoneutral housing temperature
Publikováno v:
Applied Physiology, Nutrition, and Metabolism. 45:411-420
Sprint interval training (SIT) has demonstrated reductions in fat mass through potential alterations in postexercise metabolism. This study examined whether exercising in the fasted or fed state affects postexercise metabolism following acute SIT. Te
Autor:
David C. Wright, Greg L. McKie
Publikováno v:
Biochemical Journal. 477:1061-1081
Our understanding of white adipose tissue (WAT) biochemistry has evolved over the last few decades and it is now clear that WAT is not simply a site of energy storage, but rather a pliable endocrine organ demonstrating dynamic responsiveness to the e
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(3)
Increasing whole-body energy expenditure via the pharmacological activation of uncoupling protein 1 (UCP1)-dependent brown adipose tissue (BAT) thermogenesis is a promising weight management strategy, yet most therapeutics studied in rodents to date