Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Greg J. Towers"'
Publikováno v:
Retrovirology, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Detection of viruses by host pattern recognition receptors induces the expression of type I interferon (IFN) and IFN-stimulated genes (ISGs), which suppress viral replication. Numerous studies have described HIV-1 as a poor activa
Externí odkaz:
https://doaj.org/article/6d27326a2da4481b82ccd12716fb9fdd
Autor:
Douglas L. Fink, James Cai, Matthew V. X. Whelan, Christopher Monit, Carlos Maluquer de Motes, Greg J. Towers, Rebecca P. Sumner
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background The NF-κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF-κB transcription factors by viral pathogen-associated molecular patterns, such
Externí odkaz:
https://doaj.org/article/83664ea4d57d46588314b53c167d7d2b
Autor:
Carolina B. Ferreira, Rebecca P. Sumner, Maria T. Rodriguez-Plata, Jane Rasaiyaah, Richard S. Milne, Adrian J. Thrasher, Waseem Qasim, Greg J. Towers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 209-219 (2020)
Most gene therapy lentiviral vector (LV) production platforms employ HEK293T cells expressing the oncogenic SV40 large T-antigen (TAg) that is thought to promote plasmid-mediated gene expression. Studies on other viral oncogenes suggest that TAg may
Externí odkaz:
https://doaj.org/article/5ec497afb24c436c8f1efc7f27c66a59
Autor:
Charles R. Dixon, Poonam Malik, Jose I. de las Heras, Natalia Saiz-Ros, Flavia de Lima Alves, Mark Tingey, Eleanor Gaunt, A. Christine Richardson, David A. Kelly, Martin W. Goldberg, Greg J. Towers, Weidong Yang, Juri Rappsilber, Paul Digard, Eric C. Schirmer
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103055- (2021)
Summary: STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of
Externí odkaz:
https://doaj.org/article/7c77bb3feb48478187feaae2f2cec97e
Publikováno v:
BMC Evolutionary Biology, Vol 19, Iss 1, Pp 1-4 (2019)
Abstract Background Studying site-specific amino acid frequencies by eye can reveal biologically significant variability and lineage-specific adaptation. This so-called ‘sequence gazing’ often informs bioinformatics and experimental research. But
Externí odkaz:
https://doaj.org/article/99780ea4862d4cacaa9aa3e33c2f2ec7
Autor:
Rawlings Datir, Steven Kemp, Kate El Bouzidi, Petra Mlchocova, Richard Goldstein, Judy Breuer, Greg J. Towers, Clare Jolly, Miguel E. Quiñones-Mateu, Patrick S. Dakum, Nicaise Ndembi, Ravindra K. Gupta
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Protease inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought to explore the
Externí odkaz:
https://doaj.org/article/7199b87aeca649fba51303efebde939d
Autor:
Emmanuel Atangana Maze, Claire Ham, Jack Kelly, Lindsay Ussher, Neil Almond, Greg J. Towers, Neil Berry, Robert Belshaw
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Retroviral replication leaves a DNA copy in the host cell chromosome, which over millions of years of infection of germline cells has led to 5% of the human genome sequence being comprised of endogenous retroviruses (ERVs), distributed throughout an
Externí odkaz:
https://doaj.org/article/b6cd3d6d28024df28ce0dcd2f6258114
Autor:
Rebecca P. Sumner, Lucy G. Thorne, Doug L. Fink, Hataf Khan, Richard S. Milne, Greg J. Towers
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
HIV-1 is the single most important sexually transmitted disease in humans from a global health perspective. Among human lentiviruses, HIV-1 M group has uniquely achieved pandemic levels of human-to-human transmission. The requirement to transmit betw
Externí odkaz:
https://doaj.org/article/89ccb8cbdbee4b7b8e63fbc52548bca0
Publikováno v:
Viruses, Vol 6, Iss 1, Pp 243-263 (2014)
Restriction factors are a collection of antiviral proteins that form an important aspect of the innate immune system. Their constitutive expression allows immediate response to viral infection, ahead of other innate or adaptive immune responses. We r
Externí odkaz:
https://doaj.org/article/4e10a1fe0525495fbbbcc11ec212b978
Autor:
Ravindra K. Gupta, Greg J. Towers
Publikováno v:
Viruses, Vol 2, Iss 4, Pp 987-994 (2010)
Tetherin is an antiviral restriction factor made by mammalian cells to protect them from viral infection. It prevents newly formed virus particles from leaving infected cells. Its antiviral mechanism appears to be remarkably uncomplicated. In 2 studi
Externí odkaz:
https://doaj.org/article/00871c913e944ec497ca5ee960b51b61