Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Greg J. Bashaw"'
Autor:
Kaitlin M. Laws, Greg J. Bashaw
Publikováno v:
Natural Sciences, Vol 2, Iss 4, Pp n/a-n/a (2022)
Abstract Classical axon guidance ligands and their neuronal receptors were first identified due to their fundamental roles in regulating connectivity in the developing nervous system. Since their initial discovery, it has become clear that these sign
Externí odkaz:
https://doaj.org/article/b5e5fac81e80439a9e7bb812e823f134
Autor:
Celine Santiago, Greg J. Bashaw
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1646-1659 (2017)
Motor neuron axon targeting in the periphery is correlated with the positions of motor neuron inputs in the CNS, but how these processes are coordinated to form a myotopic map remains poorly understood. We show that the LIM homeodomain factor Islet (
Externí odkaz:
https://doaj.org/article/06b55aa02d914f4dbf05230245cf1a93
Autor:
Madhavi Gorla, Celine Santiago, Karina Chaudhari, Awo Akosua Kesewa Layman, Paula M. Oliver, Greg J. Bashaw
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3298-3312.e4 (2019)
Summary: Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. This switch prevents axons from re-entering the midline. In insects and mammals, negative regulation of R
Externí odkaz:
https://doaj.org/article/307034212df34e88a8ebfa9fd91a9a07
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 153-165 (2014)
Transcription factors establish neural diversity and wiring specificity; however, how they orchestrate changes in cell morphology remains poorly understood. The Drosophila Roundabout (Robo) receptors regulate connectivity in the CNS, but how their pr
Externí odkaz:
https://doaj.org/article/e6daafd22d5d417fbd3b97cf04355ce9
Publikováno v:
eLife, Vol 10 (2021)
The Roundabout (Robo) guidance receptor family induces axon repulsion in response to its ligand Slit by inducing local cytoskeletal changes; however, the link to the cytoskeleton and the nature of these cytoskeletal changes are poorly understood. Her
Externí odkaz:
https://doaj.org/article/c69636800f26467780990d10d50246b7
Autor:
Kelly G, Sullivan, Greg J, Bashaw
Publikováno v:
Neuroscience. 508:123-136
Friedrich Bonhoeffer made seminal contributions to the study of axon guidance in the developing nervous system. His discoveries of key cellular and molecular mechanisms that dictate wiring specificity laid the foundation for countless investigators w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb401794d962c321b988419f25e615b
https://doi.org/10.1016/j.neuroscience.2022.07.012
https://doi.org/10.1016/j.neuroscience.2022.07.012
Autor:
Karina Chaudhari, Kaiyue Zhang, Patricia T. Yam, Yixin Zang, Daniel A. Kramer, Sabrina Schlienger, Sara Calabretta, Meagan Collins, Myriam Srour, Baoyu Chen, Frédéric Charron, Greg J. Bashaw
SUMMARYThe axon guidance cue, Netrin-1, signals through its receptor DCC to attract commissural axons to the midline. Pathogenic variants in DCC frequently lead to congenital mirror movements (CMM), but how these variants impact DCC function is large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::811cae0cd779480f8f7dd91990f4868f
https://doi.org/10.1101/2022.10.13.511954
https://doi.org/10.1101/2022.10.13.511954
Publikováno v:
J Neurosci
Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. In insects and mammals, negative regulation of the surface expression of Roundabout (Robo) receptors prevents prem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac59a0fbcef4fc41d5ecf37333646e8
https://europepmc.org/articles/PMC9546450/
https://europepmc.org/articles/PMC9546450/
Publikováno v:
Cell reports. 41(10)
Frazzled (Fra) and deleted in colorectal cancer (Dcc) are homologous receptors that promote axon attraction in response to netrin. In Drosophila, Fra also acts independently of netrin by releasing an intracellular domain (ICD) that activates gene tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f120fa46e4a8c9f682aa28924c50f61
https://pubmed.ncbi.nlm.nih.gov/36476876
https://pubmed.ncbi.nlm.nih.gov/36476876