Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Greg Holtz"'
Autor:
Jeffery J. Anderson, Mark A. Varney, Christopher D. King, Margaret J. Bradbury, Deborah F. Chapman, Greg Holtz, Nicholas D. P. Cosford, Jeffrey R. Roppe, Darlene R. Giracello
Publikováno v:
European Journal of Pharmacology. 473:35-40
In vivo receptor occupancy of mGlu5 receptor antagonists was quantified in rat and mouse brain using the mGlu5 receptor selective antagonist [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine) ([3H]methoxy-PEPy). Administration of [3H]methoxy-PEPy (50 mic
Autor:
Darlene R. Giracello, Blake A. Rowe, Nicholas D. P. Cosford, Mark A. Varney, Deborah F. Chapman, Margaret J. Bradbury, Jeffery J. Anderson, Lida R. Tehrani, Greg Holtz, Sara P. Rao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:1044-1051
The binding of [3H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (methoxymethyl-MTEP), a potent and selective antagonist for metabotropic glutamate (mGlu)5 receptors, was characterized in rat brain both in vitro and in vivo. Nonspecifi
Autor:
John D. Gearhart, Linda M. Call, Steven L. Wagner, Ann M. Lawler, Steven G. Younkin, Donald L. Price, Sangram S. Sisodia, Hilda H. Slunt, Kimberly A. Bardel, Greg Holtz, Bruce T. Lamb, Christopher B. Eckman
Publikováno v:
Human Molecular Genetics. 6:1535-1541
Missense mutations in the beta-amyloid precursor protein gene (APP) co-segregate with a small subset of autosomal dominant familial Alzheimer's disease (FAD) cases wherein deposition of the 39-43 amino acid beta-amyloid (A beta) peptide and neurodege
Autor:
Kevin M. Felsenstein, Maria Z. Kounnas, Blake A. Rowe, Jeffery J. Anderson, Bowei Wang, Kumar Srinivasan, Mary S. Turner, Patricia P. Baskin, Ian A. McDonald, Steven L. Wagner, Greg Holtz, Bruce T. Lamb, Donna M. Barten, Ben Munoz
Publikováno v:
Biochemical pharmacology. 69(4)
A primary pathological feature of Alzheimer's disease is beta-amyloid (Abeta)-containing plaques in brain and cerebral vasculature. Reductions in the formation of Abeta peptides by gamma-secretase inhibitors may be a viable therapy for reducing Abeta
Autor:
Margaret J. Bradbury, Greg Holtz, Sara Rao, Mark A. Varney, Darlene R. Giracello, Jeffery J. Anderson, Deborah F. Chapman, H. Schaffhauser
Publikováno v:
Neuropharmacology. 44(5)
The mGluR5 antagonist 2-methyl-6-(phenylethynyl) pyridine (MPEP) produces anxiolytic or antidepressant effects in several rodent models through incompletely described mechanisms. Anxiolytics and antidepressants share several neuroendocrine features,
Autor:
Christian Lesuisse, Fai Tang, Steve Wagner, Victoria Gonzalez, Jeffery J. Anderson, Guilian Xu, David R. Borchelt, Molly Pik-Fan Wong, Joanna L. Jankowsky, Greg Holtz, Donald L. Price, Philip C. Wong
Publikováno v:
Human molecular genetics. 10(22)
Recent studies in mice have clearly demonstrated that eliminating Apo E alters the rate, character and distribution of A beta deposits. In the present study, we asked whether elevating the levels of Apo E can, in a dominant fashion, influence amyloid
Autor:
Bruce A. Lamb, Jeffrey Anderson, Laura Shapiro Kulnane, Kimberly A. Bardel, Greg Holtz, Sangram S. Sisodia, Steven L. Wagner, Emily J. Hoeger
Publikováno v:
Nature neuroscience. 2(8)
Dosage imbalance for chromosome 21 in Down syndrome and mutations in the amyloid precursor protein (APP) and presenilin-1 (PS-1 ) genes in early-onset familial Alzheimer's disease (FAD) result in elevated production and deposition of amyloid-β (Aβ)
Publikováno v:
Journal of Biological Chemistry. 258:10007-10012
The coat protein of the small RNA virus MS2 shows charge heterogeneity in vivo. In most strains there is a basic satellite of the native protein. We have shown that this basic satellite is greatly diminished or absent in strains with the streptomycin
Autor:
J, Anderson Jeffery, P, Rao Sara, Blake, Rowe, R, Giracello Darlene, Greg, Holtz, F, Chapman Deborah, Lida, Tehrani, J, Bradbury Margaret, P, Cosford Nicholas D, A, Varney Mark
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; December 2002, Vol. 303 Issue: 3 p1044-51, 8p
Autor:
Jack Parker, Greg Holtz
Publikováno v:
Biochemical and biophysical research communications. 121(2)
Basal-level misreading of asparagine codons was examined in a number of Escherichia coli strains. Lysine substitutions were measured by quantitating the amount of charge heterogeneity in MS2 coat protein. In most strains the heterogeneity was consist