Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Greg Hodge"'
Autor:
Greg Hodge, Hubertus Jersmann, Mark Holmes, Patrick Asare, Eugene Roscioli, Paul N. Reynolds, Sandra Hodge
Publikováno v:
Biology, Vol 12, Iss 9, p 1261 (2023)
Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs and also in the peripheral circulation of both smokers and chronic obstructive pulmonary disease (COPD) patients. The reason for this is unclear but has been described as a spillo
Externí odkaz:
https://doaj.org/article/a2f00e34891a48c98c0515b1233566ce
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 14 (2020)
Background: The class III NAD-dependent histone deacetylase (HDAC) sirtuin 1 (SIRT1) is an important regulator of senescence, aging, and inflammation. SIRT1de-acetylates chromatin histones, thereby silencing inflammatory gene transcription. We have r
Externí odkaz:
https://doaj.org/article/f929d0fc1de84ab796fc790cd960fd5a
Autor:
Alice C-H. Chen, Hai B. Tran, Yang Xi, Stephanie T. Yerkovich, Katherine J. Baines, Susan J. Pizzutto, Melanie Carroll, Avril A.B. Robertson, Matthew A. Cooper, Kate Schroder, Jodie L. Simpson, Peter G. Gibson, Greg Hodge, Ian B. Masters, Helen M. Buntain, Helen L. Petsky, Samantha J. Prime, Anne B. Chang, Sandra Hodge, John W. Upham
Publikováno v:
ERJ Open Research, Vol 4, Iss 1 (2018)
Protracted bacterial bronchitis (PBB) in young children is characterised by prolonged wet cough, prominent airway interleukin (IL)-1β expression and infection, often with nontypeable Haemophilus influenzae (NTHi). The mechanisms responsible for IL-1
Externí odkaz:
https://doaj.org/article/38913608e0474e6c9cbe0fa34b676bac
Autor:
Hai B Tran, Hubertus Jersmann, Tung Thanh Truong, Rhys Hamon, Eugene Roscioli, Miranda Ween, Melissa R Pitman, Stuart M Pitson, Greg Hodge, Paul N Reynolds, Sandra Hodge
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0179577 (2017)
We have previously established a link between impaired phagocytic capacity and deregulated S1P signaling in alveolar macrophages from COPD subjects. We hypothesize that this defect may include a disruption of epithelial-macrophage crosstalk via Spns2
Externí odkaz:
https://doaj.org/article/4866f6d998654c978d76ea4dc28e27ae
Autor:
Greg Hodge, Sandra Hodge
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Corticosteroid resistance is a major barrier to effective treatment in chronic obstructive pulmonary disease (COPD), and failure to suppress systemic inflammation in these patients may result in increased co-morbidity. Although much of the research t
Externí odkaz:
https://doaj.org/article/a2203360714a4619ac0d8ce3b6e8bb71
Autor:
Greg Hodge, Sandra Hodge
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1511 (2019)
The innate immune system drives the initiation of inflammation and progression to chronic inflammation in two important chronic inflammatory lung diseases involving the small airways, chronic obstructive pulmonary disease (COPD) and bronchiolitis obl
Externí odkaz:
https://doaj.org/article/2e1f658fd8774579965cd230067515c6
Publikováno v:
Biologics: Targets & Therapy, Vol 2008, Iss Issue 1, Pp 143-149 (2008)
Greg Hodge1, Stephen Davis2, Michael Rice1, Heather Tapp1, Ben Saxon1, Tamas Revesz11Haematology/Oncology Department, Women’s and Children’s Hospital, North Adelaide, Australia; 2Department of Mycology, Women’s and Children’s Hospital, North
Externí odkaz:
https://doaj.org/article/444a6efa335b400ead33387ef18809b3
Autor:
Jameel Barnawi, Hai Tran, Hubertus Jersmann, Stuart Pitson, Eugene Roscioli, Greg Hodge, Robyn Meech, Rainer Haberberger, Sandra Hodge
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0122771 (2015)
We previously reported that alveolar macrophages from patients with chronic obstructive pulmonary disease (COPD) are defective in their ability to phagocytose apoptotic cells, with a similar defect in response to cigarette smoke. The exact mechanisms
Externí odkaz:
https://doaj.org/article/92a71e72d1d24df29f3476241e269673
Autor:
Hai B Tran, Jessica Ahern, Greg Hodge, Phillip Holt, Melinda M Dean, Paul N Reynolds, Sandra Hodge
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98571 (2014)
We have previously established that a defect in the ability of alveolar macrophages (AM) to phagocytose apoptotic cells (efferocytosis) and pathogens is a potential therapeutic target in COPD. We further showed that levels of mannose binding lectin (
Externí odkaz:
https://doaj.org/article/7deb6dbf33b543c78c6e7fb540c43161
Autor:
Francis C Dehle, Violet R Mukaro, Craig Jurisevic, David Moffat, Jessica Ahern, Greg Hodge, Hubertus Jersmann, Paul N Reynolds, Sandra Hodge
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61573 (2013)
In chronic obstructive pulmonary disease (COPD/emphysema) we have shown a reduced ability of lung and alveolar (AM) macrophages to phagocytose apoptotic cells (defective 'efferocytosis'), associated with evidence of secondary cellular necrosis and a
Externí odkaz:
https://doaj.org/article/708bb7843b4d4f1fbecaa35318e64000