Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Greg Haug"'
Autor:
Surajit Dey, Wenying Lu, Greg Haug, Collin Chia, Josie Larby, Heinrich C. Weber, Archana Vijay Gaikwad, Prem Bhattarai, Affan Mahmood Shahzad, Prabuddha S. Pathinayake, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Although asthma and chronic obstructive pulmonary disease (COPD) are two distinct chronic airway inflammatory diseases, they often co-exist in a patient and the condition is referred to as asthma-COPD overlap (ACO). Lack of eviden
Externí odkaz:
https://doaj.org/article/5e348fad49dd4876b16753136037991c
Autor:
Samuel James Brake, Wenying Lu, Collin Chia, Greg Haug, Josie Larby, Ashutosh Hardikar, Gurpreet K. Singhera, Tillie L. Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCOPD is a common disease characterized by respiratory airflow obstruction. TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving epithelial mesenchymal transition (EMT).MethodsWe investigated TGF-β1 signalling
Externí odkaz:
https://doaj.org/article/1785ac62c9de46619da72af6e7aa262d
Autor:
Archana Vijay Gaikwad, Wenying Lu, Surajit Dey, Prem Bhattarai, Greg Haug, Josie Larby, Collin Chia, Jade Jaffar, Glen Westall, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background We have previously reported arterial remodelling in patients with idiopathic pulmonary fibrosis (IPF) and suggested that endothelial-to-mesenchymal transition (EndMT) might be central to these changes. This study aims to provide evidence f
Externí odkaz:
https://doaj.org/article/b49ad27c47024587a61b641213c727bf
Autor:
Prem Bhattarai, Wenying Lu, Archana Vijay Gaikwad, Surajit Dey, Collin Chia, Josie Larby, Greg Haug, Ashutosh Hardikar, Andrew Williams, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
ERJ Open Research, Vol 8, Iss 4 (2022)
Introduction Pulmonary vascular remodelling in chronic obstructive pulmonary disease (COPD) has detrimental consequences for lung physiology. The aim of our study was to provide a comprehensive size-based morphometric quantification of pulmonary arte
Externí odkaz:
https://doaj.org/article/52836600fe7a4a06ad575edb484c53ab
Autor:
Archana Vijay Gaikwad, Wenying Lu, Surajit Dey, Prem Bhattarai, Collin Chia, Josie Larby, Greg Haug, Stephen Myers, Jade Jaffar, Glen Westall, Gurpreet Kaur Singhera, Tillie-Louise Hackett, James Markos, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
ERJ Open Research, Vol 8, Iss 1 (2022)
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic interstitial lung disease. We performed size-based quantitation of pulmonary arterial remodelling in IPF and examined the role of endothelial-to-mesenchymal transi
Externí odkaz:
https://doaj.org/article/cf0b599125c9433998a32829faa4515e
Autor:
Wenying Lu, Mathew Suji Eapen, Gurpreet Kaur Singhera, James Markos, Greg Haug, Collin Chia, Josie Larby, Samuel James Brake, Glen P. Westall, Jade Jaffar, Rama Satyanarayana Raju Kalidhindi, Nimesha De Fonseka, Venkatachalem Sathish, Tillie L. Hackett, Sukhwinder Singh Sohal
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 3, p 777 (2022)
We previously reported higher ACE2 levels in smokers and patients with COPD. The current study investigates if patients with interstitial lung diseases (ILDs) such as IPF and LAM have elevated ACE2, TMPRSS2, and Furin levels, increasing their risk fo
Externí odkaz:
https://doaj.org/article/c6f11c7525ec4d2697c183b1410705ad
Autor:
Kielan Darcy McAlinden, Wenying Lu, Parisa Vahidi Ferdowsi, Stephen Myers, James Markos, Josie Larby, Collin Chia, Heinrich C. Weber, Greg Haug, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 5, p 1028 (2021)
Tobacco smoking has emerged as a risk factor for increasing the susceptibility to infection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via increased expression of angiotensin-converting enzyme-2 (ACE2) in the lung, linked to co
Externí odkaz:
https://doaj.org/article/7a3322d9b1ec48129bf90663718f4047
Autor:
Sanjay S Gautam, Micheál Mac Aogáin, Louise A Cooley, Greg Haug, Janet A Fyfe, Maria Globan, Ronan F O'Toole
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192351 (2018)
The origin and spread of tuberculosis (TB) in Tasmania and the types of strains of Mycobacterium tuberculosis complex (MTBC) present in the population are largely unknown.The aim of this study was to perform the first genomic analysis of MTBC isolate
Externí odkaz:
https://doaj.org/article/805bd701561b497da69189056900206b
Autor:
Archana Vijay Gaikwad, Wenying Lu, Surajit Dey, Prem Bhattarai, Collin Chia, Josie Larby, Greg Haug, Stephen Myers, Jade Jaffar, Glen Westall, Gurpreet Kaur Singhera, Tillie-Louise Hackett, James Markos, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
ERJ Open Research. :00571-2021
BackgroundIPF is a progressive, irreversible fibrotic interstitial lung disease. We performed size-based quantitation of pulmonary arterial remodelling in IPF, examined the role of EndMT and effects on lung physiology.MethodsResected lung tissues fro
Autor:
Surajit Dey, Wenying Lu, Heinrich C. Weber, Sally Young, Josie Larby, Collin Chia, Greg Haug, Samuel James Brake, Stephen Myers, Archana Vijay Gaikwad, Prem Bhattarai, Prabuddha S. Pathinayake, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(4)
Management of patients with asthma COPD overlap (ACO) is clinically challenging due to insufficient evidence of pathological changes in these patients. In this cross-sectional study, we evaluated airway remodeling in endobronchial biopsies from a tot