Modelling the impact of CD4 testing on mortality from TB and cryptococcal meningitis among patients with advanced HIV disease in nine countries

Autor: Ikwo Kitefre Oboho, Heather Paulin, Carl Corcoran, Matt Hamilton, Alex Jordan, Hannah L. Kirking, Elfriede Agyemang, Laura Jean Podewils, Carel Pretorius, Greg Greene, Tom Chiller, Mitesh Desai, Roma Bhatkoti, Ray W. Shiraishi, N. Sarita Shah

Publikováno v: Journal of the International AIDS Society, Vol 26, Iss 3, Pp n/a-n/a (2023)

Abstract Introduction Despite antiretroviral therapy (ART) scale‐up among people living with HIV (PLHIV), those with advanced HIV disease (AHD) (defined in adults as CD4 count

Externí odkaz: https://doaj.org/article/5b2bd807ed71402fb569769ba8eed659

Evaluation of the effectiveness of a South African laboratory cryptococcal antigen screening programme using a retrospective cohort and a cluster-randomised trial design

Autor: David R Boulware, Radha Rajasingham, Rudzani Mashau, Nelesh P Govender, Daniel J DeSanto, Ananta S Bangdiwala, Erika Van Schalkwyk, Caleb P Skipper, Greg Greene, Juliet Paxton, Kathy Huppler Hullsiek

Publikováno v: BMJ Open, Vol 12, Iss 8 (2022)

Introduction Cryptococcal meningitis is a common fungal opportunistic infection and a leading cause of death among people with advanced HIV disease in sub-Saharan Africa. The WHO recommends cryptococcal antigen (CrAg) screening followed by pre-emptiv

Externí odkaz: https://doaj.org/article/943d1bfe27554ed790d59db44b79e441

Impact of prior cryptococcal antigen screening on in-hospital mortality in cryptococcal meningitis or fungaemia among HIV-seropositive individuals in South Africa: a cross-sectional observational study

Autor: Olivier Paccoud, Liliwe Shuping, Rudzani Mashau, Greg Greene, Vanessa Quan, Susan Meiring, Nelesh P. Govender, Shareef Abrahams, Khatija Ahmed, Theunis Avenant, Colleen Bamford, Prathna Bhola, Kate Bishop, John Black, Lucille Blumberg, Norma Bosman, Maria Botha, Adrian Brink, Suzy Budavari, Asmeeta Burra, Vindana Chibabhai, Rispah Chomba, Cheryl Cohen, Yacoob Coovadia, Penny Crowther-Gibson, Halima Dawood, Linda de Gouveia, Nomonde Dlamini, Siyanda Dlamini, Andries Dreyer, Nicolette du Plessis, Erna du Plessis, Mignon du Plessis, Linda Erasmus, Charles Feldman, Nelesh Govender, Chetna Govind, Michelle Groome, Sumayya Haffejee, Ken Hamese, Carel Haumann, Nombulelo Hoho, Anwar Hoosen, Ebrahim Hoosien, Victoria Howell, Greta Hoyland, Farzana Ismail, Husna Ismail, Nazir Ismail, Prudence Ive, Pieter Jooste, Alan Karstaedt, Ignatius Khantsi, Vicky Kleinhans, Jackie Kleynhans, Molebogeng Kolojane, Tendesayi Kufa-Chakezha, Tiisetso Lebaka, Jacob Lebudi, Neo Legare, Ruth Lekalakala, Kathy Lindeque, Warren Lowman, Shabir Madhi, Rindidzani Magobo, Prasha Mahabeer, Adhil Maharaj, Martha Makgoba, Molatji Maloba, Caroline Maluleka, Mokupi Manaka, Phetho Mangena, Nontuthuko Maningi, Louis Marcus, Terry Marshall, Rudzani Mathebula, Azwifarwi Mathunjwa, Nontombi Mbelle, Bongani Mbuthu, Kerrigan McCarthy, Omphile Mekgoe, Colin Menezes, Cecilia Miller, Koleka Mlisana, Masego Moncho, David Moore, Myra Moremi, Lynn Morris, Moamokgethi Moshe, Lesego Mothibi, Harry Moultrie, Ruth Mpembe, Portia Mutevedzi, Judith Mwansa-Kambafwile, Fathima Naby, Preneshni Naicker, Romola Naidoo, Trusha Nana, Maphoshane Nchabeleng, Phathutshedzo Ndlovu, Jeremy Nel, Mimmy Ngomane, Wendy Ngubane, Mark Nicol, Sunnieboy Njikho, Grace Ntlemo, Sindi Ntuli, Nicola Page, Nuraan Paulse, Vanessa Pearce, Olga Perovic, Keshree Pillay, Dina Pombo, Xoliswa Poswa, Elizabeth Prentice, Adrian Puren, Praksha Ramjathan, Yeishna Ramkillawan, Kessendri Reddy, Gary Reubenson, Lauren Richards, Mohammed Said, Nazlee Samodien, Catherine Samuel, Sharona Seetharam, Phuti Sekwadi, Mirriam Selekisho, Marthinus Senekal, Ngoaka Sibiya, Surendra Sirkar, Juanita Smit, Anthony Smith, Marshagne Smith, Lisha Sookan, Charlotte Sriruttan, Sarah Stacey, Khine Swe Swe Han, Teena Thomas, Juno Thomas, Merika Tsisti, Erika van Schalkwyk, Ebrahim Variava, Phumeza Vazi, Charl Verwey, Anne von Gottberg, Jeanntte Wadula, Sibongile Walaza, Linda Wende, Andrew Whitelaw, Douglas Wilson, Inge Zietsman

Publikováno v: Clinical Microbiology and Infection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44a585d522ec7bb9b46f2c4d1f510b56
https://doi.org/10.1016/j.cmi.2023.04.016

Cost-effectiveness of cryptococcal antigen screening at CD4 counts of 101-200 cells/µL in Botswana

Autor: Mark W. Tenforde, Charles Muthoga, Ponego Ponatshego, Julia Ngidi, Madisa Mine, Greg Greene, Alexander Jordan, Tom Chiller, Bruce A. Larson, Joseph N. Jarvis

Publikováno v: Wellcome Open Research

Background: Cryptococcal antigen (CrAg) screening in individuals with advanced HIV reduces cryptococcal meningitis (CM) cases and deaths. The World Health Organization recently recommended increasing screening thresholds from CD4 ≤100 cells/µL to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1820c9558f6450c059a2e05c8bc9103c
https://researchonline.lshtm.ac.uk/id/eprint/4662471/1/37431898-4927-4891-9b6c-31455ba647dd_16624_-_mark_tenforde.pdf

Looking for fungi in all the right places

Autor: Charlotte Sriruttan, Greg Greene, Thuy Le, Nelesh P. Govender, Tom Chiller

Publikováno v: Current Opinion in HIV and AIDS. 12:139-147

PURPOSE OF REVIEW: As HIV treatment programmes scale up to meet the UNAIDS 90-90-90 goals, care must be taken to start antiretroviral treatment safely in patients with advanced disease (CD4 counts RECENT FINDINGS: Cryptococcal antigen (CrAg) screenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7235ba4cacaff1d6a7c7cde81f15c1a
https://doi.org/10.1097/coh.0000000000000347