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Autor:
John M. Goldman, Roger Briesewitz, Ross L. Levine, Steve R. Roof, Joshua J. Oaks, Kyosuke Nagata, Besim Ogretmen, Guido Marcucci, Alistair Reid, Dragana Milojkovic, James R. Van Brocklyn, Robert Bittman, Mark T. Ziolo, Omar Abdel-Wahab, Christopher J. Walker, Ann-Kathrin Eisfeld, Jane F. Apperley, Ralph B. Arlinghaus, Michael A. Caligiuri, Danilo Perrotti, Jason G. Harb, Greg Ferenchak, Paolo Neviani, Ramasamy Santhanam, Sahar A. Saddoughi, Alfonso Quintás-Cardama
Publikováno v:
Blood. 122(11)
FTY720 (Fingolimod, Gilenya) is a sphingosine analog used as an immunosuppressant in multiple sclerosis patients. FTY720 is also a potent protein phosphatase 2A (PP2A)-activating drug (PAD). PP2A is a tumor suppressor found inactivated in different t