Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Greg Falls"'
Autor:
Lei Chen, Paula Milani de Marval, Kendall Powell, Mark Johnson, Greg Falls, Brian Lawhorn, Aurélie Candi, Amuri Kilonda, Bart Vanderhoydonck, Arnaud Marchand, Matthias Versele, Georg Halder, Stephen L. Gwaltney, Adeela Kamal
Publikováno v:
Cancer Research. 83:4964-4964
Many cancers harbor mutations in the Hippo pathway that lead to constitutive activation of the transcriptional co-activators YAP/TAZ that then bind the transcription factor TEAD and drive aberrant transcription of target genes involved in cell prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff72fff7f3b3f1feb5934f47b68973aa
https://doi.org/10.1158/1538-7445.am2023-4964
https://doi.org/10.1158/1538-7445.am2023-4964
Autor:
Cassandra L. Gorsuch, Paige Nemec, Mei Yu, Simin Xu, Dong Han, Jeff Smith, Janel Lape, Nicholas van Buuren, Ricardo Ramirez, Robert C. Muench, Meghan M. Holdorf, Becket Feierbach, Greg Falls, Jason Holt, Wendy Shoop, Emma Sevigny, Forrest Karriker, Robert V. Brown, Amod Joshi, Tyler Goodwin, Ying K. Tam, Paulo J.C. Lin, Sean C. Semple, Neil Leatherbury, William E. Delaney IV, Derek Jantz, Amy Rhoden Smith
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 30(9)
Persistence of chronic hepatitis B (CHB) is attributed to maintenance of the intrahepatic pool of the viral covalently closed circular DNA (cccDNA), which serves as the transcriptional template for all viral gene products required for replication. Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84018ffdfd1b7ba8ad4140522c540384
https://pubmed.ncbi.nlm.nih.gov/35581938
https://pubmed.ncbi.nlm.nih.gov/35581938
Autor:
Neal F. Cariello, Heidi M. Colton, Holly L. Jordan, Brenda Faiola, Alan H. Stokes, Brian R. Berridge, Lawrence Yoon, J. Greg Falls
Publikováno v:
International Journal of Toxicology. 34:151-161
Cardiovascular (CV) safety concerns are among the leading causes of compound attrition in drug development. This work describes a strategy of applying novel end points to a 7-day rodent study to increase the opportunity to detect and characterize CV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2aea204fafc2f6ca2bc3528ccbef5c
https://doi.org/10.1177/1091581815573029
https://doi.org/10.1177/1091581815573029
Autor:
Amanda Mathis, Wenyan Mo, Susan Long, Stephanie Anna Chan, Jill Walker, Ryan Lauchli, Martin Robert Leivers, Elizabeth M. Turner, Tony Ton, Sebastian Liehr, J. Greg Falls, John F. Miller, Michael Youngman
Publikováno v:
Journal of Medicinal Chemistry. 57:1964-1975
By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac356040e8f55946d9a047bcc57f508d
https://doi.org/10.1021/jm401337x
https://doi.org/10.1021/jm401337x
Autor:
James Greg Falls, Douglas C. Wolf, Yvonne P. Dragan, Michael L. Cunnningham, Darlene Dixon, Karen A. Augustine, Syril D. Pettit, Robert C. Sills, Jay I. Goodman, Richard D. Storer, Reza J. Rasoulpour
Publikováno v:
Toxicological Sciences. 116:375-381
The International Life Sciences Institute, Health and Environmental Sciences Institute sponsored a workshop entitled "State of the Science: Evaluating Epigenetic Changes," hosted by the National Institute of Environmental Health Sciences, Research Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab0beff31679d2572e90ae554c3f76a
https://doi.org/10.1093/toxsci/kfq133
https://doi.org/10.1093/toxsci/kfq133
Autor:
Connie A. Cummings, James Greg Falls, Nancy R. Bordelon, Richard A. Peterson, Thomas A. Brodie, Elizabeth H. Romach, Richard T. Miller, Brenda Faiola
Publikováno v:
Toxicological Sciences. 105:384-394
Therapeutic use of certain peroxisome proliferator-activated receptor (PPAR) alpha agonists (fibrates) for the treatment of dyslipidemia has infrequently been associated with the untoward side effect of myopathy. With interest in PPAR-delta as a ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7b85eb0c631b90496aab94b750cf89
https://doi.org/10.1093/toxsci/kfn130
https://doi.org/10.1093/toxsci/kfn130
Autor:
Don Creech, Puntipa Kwanyuen, Neal F. Cariello, J. Greg Falls, Sam M. Witherspoon, Heidi M. Colton
Publikováno v:
International Journal of Toxicology. 25:41-47
Multiple methods currently exist for the assessment of peroxisome proliferation, including gene expression, enzyme activity, immunolabeling coupled with image analysis, and electron microscopy. This study describes a novel flow cytometric method to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5db540b398ad6d69223dad7860c57c
https://doi.org/10.1080/10915810500488395
https://doi.org/10.1080/10915810500488395
Autor:
Donald R Creech, Steven P. Anderson, Neal F. Cariello, Warren Casey, Debie J. Hoivik, J. Greg Falls, Heidi M. Colton, Lawrence Yoon, Gina R. Benavides, Hong Ni, Elizabeth H. Romach, Roger H. Brown, Richard T. Miller
Publikováno v:
Toxicological Sciences. 88:250-264
Fibrates, such as ciprofibrate, fenofibrate, and clofibrate, are peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists that have been in clinical use for many decades for treatment of dyslipidemia. When mice and rats are given PPARalp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4301605f9864fcbef40771906f3f567a
https://doi.org/10.1093/toxsci/kfi273
https://doi.org/10.1093/toxsci/kfi273
Publikováno v:
Pesticide Biochemistry and Physiology. 70:127-141
Several environmental chemicals are disruptive to the reproductive and endocrine systems of many species, including humans. Mechanisms for endocrine disruption are presently under scrutiny. Xenobiotic inducible mammalian cytochrome P450 (CYP) enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0212cf5e37a3da7cae53f0fc37179ef
https://doi.org/10.1006/pest.2001.2551
https://doi.org/10.1006/pest.2001.2551
Publikováno v:
Mutation Research/Reviews in Mutation Research. 436:59-67
Polymorphisms have been identified in proto-oncogenes and tumor suppressor genes that predispose people to cancer. Recent evidence indicates that genomic imprinting, an epigenetic form of gene regulation that results in uniparental gene expression, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e47c2341627ca41f1905f30d2fbf68a
https://doi.org/10.1016/s1383-5742(98)00018-0
https://doi.org/10.1016/s1383-5742(98)00018-0