Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Greg Dugan"'
[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates
Autor:
Naresh Damuka, Nagaraju Bashetti, Akiva Mintz, Avinash H. Bansode, Mack Miller, Ivan Krizan, Cristina Furdui, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, JV Shanmukha Kumar, Gagan Deep, Greg Dugan, Mark Cline, Kiran Kumar Solingapuram Sai
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113937- (2022)
Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging is recognized as the standard tool for cancer imaging, there are no clinically-approved PE
Externí odkaz:
https://doaj.org/article/9037725abf044ab3a4b3c63fe778673b
Autor:
Maurizio Ceppi, Bruno Gomes, Michael Hettich, Simon Deycmar, Brendan Johnson, Declan Ryan, William Sills, David Caudell, Greg Dugan, Kiran Solingapuram Sai, Mark Cline
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/dfa3db68ec044eb7968fc934089d8011
Autor:
Andrew N. Macintyre, PhD, Matthew J. French, BS, Brittany R. Sanders, MS, Kristina J. Riebe, BSA, Ivo D. Shterev, PhD, Kevin Wiehe, PhD, Bhavna Hora, PhD, Tyler Evangelous, BS, Greg Dugan, DVM, J. Daniel Bourland, PhD, J. Mark Cline, DVM, PhD, DACVP, Gregory D. Sempowski, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 6, Iss 5, Pp 100677- (2021)
Purpose: Ionizing radiation causes acute damage to hematopoietic and immune cells, but the long-term immunologic consequences of irradiation are poorly understood. We therefore performed a prospective study of the delayed immune effects of radiation
Externí odkaz:
https://doaj.org/article/cf7a2c6396ce41df9f74b983fd76248e
Autor:
Laura P Hale, Gowrisankar Rajam, George M Carlone, Chen Jiang, Kouros Owzar, Greg Dugan, David Caudell, Nelson Chao, J Mark Cline, Thomas C Register, Gregory D Sempowski
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0210663 (2019)
While exposure to radiation can be lifesaving in certain settings, it can also potentially result in long-lasting adverse effects, particularly to hematopoietic and immune cells. This study investigated hematopoietic recovery and immune function in r
Externí odkaz:
https://doaj.org/article/cebdfd5e42f34b19af23f350ad29677a
Autor:
John Mark Cline, Greg Dugan, John Daniel Bourland, Donna L. Perry, Joel D. Stitzel, Ashley A. Weaver, Chen Jiang, Artak Tovmasyan, Kouros Owzar, Ivan Spasojevic, Ines Batinic-Haberle, Zeljko Vujaskovic
Publikováno v:
Antioxidants, Vol 7, Iss 3, p 40 (2018)
Radiation injury to the lung is the result of acute and chronic free radical formation, and there are currently few effective means of mitigating such injury. Studies in rodents indicate that superoxide dismutase mimetics may be effective in this reg
Externí odkaz:
https://doaj.org/article/4a3613b4cc8f46bfb9fd5b2cb2ff4998
Autor:
Benny J Chen, Divino Deoliveira, Ivan Spasojevic, Gregory D Sempowski, Chen Jiang, Kouros Owzar, Xiaojuan Wang, Diane Gesty-Palmer, J Mark Cline, J Daniel Bourland, Greg Dugan, Sarah K Meadows, Pamela Daher, Garrett Muramoto, John P Chute, Nelson J Chao
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11056 (2010)
Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to mitigate against radiation injury in mice and nonhuman primates. BALB/c mice were irradiated
Externí odkaz:
https://doaj.org/article/d9e27d221d674827a1bcbca260eccf08
Autor:
Matthew J. French, Ryan Wuerker, Greg Dugan, John D. Olson, Brittany R. Sanders, Janet A. Tooze, David L. Caudell, J. Mark Cline, Gregory D. Sempowski, Andrew N. Macintyre
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 115:945-956
The aim of this study was to develop an improved understanding of the delayed immunologic effects of acute total body irradiation (TBI) using a diverse cohort of nonhuman primates as a model for an irradiated human population.Immune recovery was eval
Autor:
Simon Deycmar, Brendan Johnson, Karina Ray, David Caudell Caudell, John Olson, Greg Dugan, W. Shane Sills, Declan Ryan, Christopher Whitlow, Kiran K. Solingapuram Sai, Betsy Ferguson, Benjamin Bimber, Cassandra Cullin, Brandy Dozier, Emily Romero, Francois Villinger, Armando Burgos, Jeff Chou, Bruno Gomes, Michael Hettich, Maurizio Ceppi, Jehad Charo, J. Mark Cline
Publikováno v:
Cancer Research. 82:A021-A021
Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and emerge at similar life stages as in human patients, but the carcinogenesis and molecular background remain elusive, limiting the val
Hypertension drives microbial translocation and shifts in the fecal microbiome of non-human primates
Autor:
J. Mark Cline, Greg Dugan, Masha Block, Jordyn B. Whitfield, Kylie Kavanagh, Hao Guo, Ravichandra Vemuri, Alistaire Ruggiero
Accumulating evidence indicates a link between gut barrier dysfunction and hypertension. However, it is unclear whether hypertension dictates gut barrier dysfunction or vice versa and whether the gut microbiome plays a role. To better understand this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3018c019505f05017a8a03ff1433c10c
https://doi.org/10.1101/2021.07.30.454379
https://doi.org/10.1101/2021.07.30.454379
Autor:
Simon Deycmar, Brendan Johnson, Declan Ryan, Shane Sills, David Caudell, Greg Dugan, George Schaaf, Christopher Whitlow, Kiran Kumar Solingapuram Sai, Betsy Ferguson, Benjamin Bimber, Karina Ray, Cassandra Cullin, Brandy Dozier, Armando Burgos, Michael Hettich, Bruno Gomes, Jehad Charo, Maurizio Ceppi, Mark Cline
Publikováno v:
Cancer Research. 82:1325-1325
Background Non-human primates (NHP) such as rhesus macaques with naturally occurring cancers are a proposed model for translational cancer immunotherapy (CIT) research and have generated relevant proof-of-mechanism evidence for 3 different CIT agents