Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Greg Donoho"'
Autor:
Greg Donoho, Paul Hasty
Publikováno v:
BioTechniques, Vol 34, Iss 3, Pp 462-468 (2003)
Externí odkaz:
https://doaj.org/article/19f2b775a1b54d0ab42747cea3857351
Autor:
Vincent Vuaroqueaux, Isabella H. Wulur, Swee-Seong Wong, Manuel Landesfeind, Greg Donoho, Kerstin Klingner, Steven M. Bray, Han-Kwang Yang, Peter Bronsert, Anne-Lise Peille, Amit Aggarwal, Seong-Ho Kong, Woo Ho Kim, Bruno Zeitouni, Jason C. Ting, Christoph Reinhard, Nina Zanella, Heinz-Herbert Fiebig, Hyuk-Joon Lee
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology
Communications Biology
Patient-derived xenografts (PDX) have emerged as an important translational research tool for understanding tumor biology and enabling drug efficacy testing. They are established by transfer of patient tumor into immune compromised mice with the inte
Autor:
Jason C. Ting, Hyuk-Joon Lee, Christoph Reinhard, Vincent Vuaroqueaux, Seong-Ho Kong, Greg Donoho, Woo Ho Kim, Heinz-Herbert Fiebig, Nina Zanella, Manuel Landesfeind, Kerstin Klingner, Han-Kwang Yang, Steven M. Bray, Swee-Seong Wong, Bruno Zeitouni, Isabella H. Wulur, Anne-Lise Peille, Peter Bronsert, Amit Aggarwal
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-1 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-1 (2020)
Patient-derived xenografts (PDX) have emerged as an important translational research tool for understanding tumor biology and enabling drug efficacy testing. They are established by transfer of patient tumor into immune compromised mice with the inte
Autor:
Frank C. Dorsey, Thompson N. Doman, Kenneth D. Roth, Yanxia Li, Ruslan D. Novosiadly, Gerald Hall, Greg Donoho, Carmine Carpenito, Jason Manro, David Schaer, Erik R. Rasmussen, David Surguladze, Xiaodong Hong, Bonita D. Jones, Bo Tan, Alexander Nikolayev, Krishna Chodavarapu, Zhao Hai Lu, Shuang Luo, Manisha Brahmachary, Andrew Capen, Andreas Sonyi, Michael Kalos, Nelusha Amaladas, Darin Chin, Sandaruwan Geeganage, Catalina Meyer
Publikováno v:
Cancer Research. 79:3945-3945
Combination strategies leveraging chemotherapy and immunotherapy have held the promise as a method to improve benefit to cancer patients. However, most chemotherapies have detrimental effects on immune homeostasis and do not induce immunogenic cell d
Autor:
Aimee Lin, Christoph Reinhard, Ann M. McNulty, Jack A. Dempsey, Adem Abel, Marguerita O’Mahony, Ricardo Martinez, Damien Gerald, Greg Donoho, Carole A. Perruzzi, Wenjuan Wu, Jennifer R. Stephens
Publikováno v:
Cancer Research. 79:3513-3513
Reported genomic alterations in the DNA repair pathway in studies of castrate-resistant prostate cancer (CRPC) patients have prompted interests in targeted therapies related to the DNA damage response (DDR). CHK1 kinase plays a critical role in media
Autor:
Greg Donoho, Jennifer R. Stephens, Mark A. Castanares, Christoph Reinhard, Karsten Boehnke, Aimee Lin, Wenjuan Wu, Jack A. Dempsey, Andrew Capen, Philip W. Iversen
Publikováno v:
Cancer Research. 79:3508-3508
TNBC, the most aggressive subtype of breast cancer, is characterized by high level of genomic instability, defects in DNA damage response (DDR) and increased replication stress (RS). The current treatment options for TNBC are limited and new approach
Autor:
Ann M. McNulty, Philip W. Iversen, Christoph Reinhard, Wenjuan Wu, Greg Donoho, Louis Stancato, Jack A. Dempsey, Jennifer R. Stephens, Ricardo Martinez, Aimee Lin
Publikováno v:
Cancer Research. 79:1761-1761
HGSOC (characterized by defects in DNA damage repair and high levels of genomic instability and DNA replication stress) is the most lethal gynecological malignancy in the United States. The current treatment options for HGSOC are limited and new appr
Autor:
John A. Wijsman, Eric H. Westin, Mark T. Uhlik, Xiang Ye, Julie Stewart, Jeffrey C. Hanson, Beverly L. Falcon, Greg Donoho, Kelly M. Credille, Scharri Ezell
Publikováno v:
Drug Discovery Today. 18:510-522
Targeting multiple hallmarks of cancer with drug combinations may provide unique opportunities for cancer therapeutics; however, phenotypic quantification is necessary to understand in vivo mechanisms of action of each drug alone or in combination. I
Autor:
Amanda J. Redig, Man Xu, Atsuko Ogino, Ramon V. Tiu, Patrick Brueck, Emily S. Chambers, Hong L. Tiv, Prafulla C. Gokhale, Jihyun Choi, Paul Kirschmeier, Margaret K. Wilkens, Greg Donoho, Pasi A. Jänne, Jiaqi Li, Shripad V. Bhagwat, Jens Köhler
Publikováno v:
Cancer Research. 78:5467-5467
Introduction: RAS mutations are present in 30% of non-small cell lung cancer (NSCLC) and, despite activated MAPK signaling, MEK inhibitors have disappointed in clinical trials. MAPK pathway reactivation and activation of anti-apoptotic signaling via
Autor:
David J. Chen, Mark A. Brenneman, Dorit B. Donoviel, Tracy X. Cui, Edwin H. Goodwin, Hannes Vogel, Greg Donoho, Paul Hasty
Publikováno v:
Genes, Chromosomes and Cancer. 36:317-331
The Brca2 tumor-suppressor gene contributes to genomic stability, at least in part by a role in homologous recombinational repair. BRCA2 protein is presumed to function in homologous recombination through interactions with RAD51. Both exons 11 and 27