Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Greg D. Learn"'
Autor:
Erika L. Cyphert, Ningjing Zhang, Dylan W. Marques, Greg D. Learn, Fang Zhang, Horst A. von Recum
Publikováno v:
Journal of Functional Biomaterials, Vol 12, Iss 1, p 8 (2021)
While periprosthetic joint infections (PJIs) result in a small percentage of patients following arthroplasties, they are challenging to treat if they spread into bone and soft tissue. Treatment involves delivering antibiotics using poly(methyl methac
Externí odkaz:
https://doaj.org/article/a09efa57b97a4d2ba72e25a4f0fe5f05
Publikováno v:
ACS Biomaterials Science & Engineering. 7:4474-4482
Medical device infections are costly, while preclinical assessment of antimicrobial properties for new materials is time intensive and imperfect at capturing the interrelated aspects of infection response and wound resolution. Herein, we developed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71dad862b88acb98f650c988b192c399
https://doi.org/10.1021/acsbiomaterials.1c00505
https://doi.org/10.1021/acsbiomaterials.1c00505
Publikováno v:
ACS Biomaterials Science & Engineering. 6:4024-4035
Antibiotic-laden poly(methyl methacrylate) (PMMA) bone cement is used in a variety of applications including temporary spacers for load-bearing arthroplasties and non-load bearing orthopedic revision procedures and antibiotic beads to treat infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1305e4631ece99bc41c44c72a3fc407b
https://doi.org/10.1021/acsbiomaterials.0c00305
https://doi.org/10.1021/acsbiomaterials.0c00305
Publikováno v:
Biomacromolecules. 21:854-866
Antibiotics are commonly added to poly(methyl methacrylate) (PMMA) by surgeons to locally treat infections such as in bone cement for joint replacement surgeries, as well as implantable antimicrobial "beads". However, this strategy is of limited valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f0864b46a73b4bc79d4b56a1e4364d
https://doi.org/10.1021/acs.biomac.9b01523
https://doi.org/10.1021/acs.biomac.9b01523
Standard chemotherapy for primary and secondary bone tumors typically involves systemic administration of chemotherapeutic drugs, such as doxorubicin (DOX). However, non-targeted delivery increases dose requirements, and results in off-target toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5736becd9b62a97b718c396447f9efa1
https://doi.org/10.1101/2021.06.13.448250
https://doi.org/10.1101/2021.06.13.448250
Publikováno v:
J Biomed Mater Res A
Surgical sutures are vulnerable to bacterial infections and biofilm formation. At the suture site, pain and undesirable, excess inflammation are additionally detrimental to wound healing. The development of a polymerized cyclodextrin (pCD) coated sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1cc04c7eedf7ef398ea03b95f5c99b
https://doi.org/10.1002/jbm.a.36658
https://doi.org/10.1002/jbm.a.36658
Publikováno v:
Macromolecular bioscience. 21(7)
Antibiotic-loaded poly(methyl methacrylate) (PMMA) cement is commonly used as a local delivery system to treat and prevent orthopedic infections associated with arthroplasties in load-bearing applications. However, these delivery systems are ineffici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2d977724e85501b15f77765d8fc512
https://pubmed.ncbi.nlm.nih.gov/33885231
https://pubmed.ncbi.nlm.nih.gov/33885231
Autor:
Tejas Kashyap, Edgardo Rivera-Delgado, Dominic J. Kizek, Horst A. von Recum, Greg D. Learn, Emerson J. Lai
Publikováno v:
Journal of pharmaceutical sciences. 110(2)
An emerging approach toward repair of connective tissues applies exogenous crosslinkers to mechanically augment injured structures in vivo. One crosslinker that has been explored for this purpose is the plant-derived small molecule genipin. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e929a038eef802af604e58960adaa9d7
https://pubmed.ncbi.nlm.nih.gov/33190799
https://pubmed.ncbi.nlm.nih.gov/33190799
Undesired attachment of proteins, cells/bacteria, and organisms on material surfaces is problematic in industrial and health care settings. In this study, polymer coatings are synthesized from subunits of cyclodextrin, an additive/excipient found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f61070e1e49bc68b79d07541e9f3997
Publikováno v:
Macromolecular Bioscience. 22:2100415
Primary bone tumor resections often result in critical size defects, which then necessitate challenging clinical management approaches to reconstruct. One such intervention is the Masquelet technique, in which poly(methyl methacrylate) (PMMA) bone ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c38794144e5158741420ff121bae64
https://doi.org/10.1002/mabi.202100415
https://doi.org/10.1002/mabi.202100415