Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Greg Coates"'
Autor:
Roger Knaggs, Christoph Lohan, Alastair J Dickson, Greg Coates, Peter Clewes, Hannah Stevenson, Lucy Massey
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Objective Osteoarthritis (OA) affects 10% of adults in the UK. Despite over one-third of people with OA experiencing chronic pain, few studies have examined the population-level impact of chronic pain associated with OA. We compared resource-use and
Externí odkaz:
https://doaj.org/article/9bcf4da15e094625b7eba9f24631992d
Autor:
David Walsh, Roger Knaggs, Christoph Lohan, Robert Wood, Alastair J Dickson, Theo Tritton, Greg Coates, Peter Clewes, Hannah Stevenson
Publikováno v:
BMJ Open, Vol 13, Iss 7 (2023)
Objective Despite the prevalence of osteoarthritis (OA) in England, few studies have examined the health economic impact of chronic pain associated with OA. The aim of this study was to compare outcomes in patients with moderate-to-severe chronic pai
Externí odkaz:
https://doaj.org/article/a4328bcf2718434fb9f159de3c8f30fe
Autor:
Greg Coates, Peter Clewes, Christoph Lohan, Hannah Stevenson, Robert Wood, Theo Tritton, Roger D. Knaggs, Alastair J. Dickson, David A. Walsh
Publikováno v:
International Journal of Clinical Practice, Vol 2023 (2023)
Objective. Despite the high prevalence of chronic low back pain (CLBP) and osteoarthritis (OA), few estimates of the economic cost of these conditions in England have been published. The aim of the present analysis was to characterise the economic bu
Externí odkaz:
https://doaj.org/article/17f0f477b97347ae862c55f72ff123b1
Publikováno v:
Chemical Communications
The rapid, room-temperature defluorosilylation of trifluoromethane, a highly potent greenhouse gas, has been achieved using a simple silyl lithium reagent. An extensive computational mechanistic analysis provides a viable reaction pathway and demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e68a1f7e1eee0abc8f2c9cf610e4a9d
Publikováno v:
Angewandte Chemie International Edition
A number of new magnesium and lithium silyl reagents were prepared and shown to be outstanding nucleophiles in reactions with industrially relevant fluoroolefins. These reactions result in a net transformation of either sp2 or sp3 C-F bonds into C-Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bde7bd64100f904d2e9aef5bc141110
http://hdl.handle.net/10044/1/71022
http://hdl.handle.net/10044/1/71022
Publikováno v:
Synlett
In this Account we describe a series of new reactions that we, and others, have reported that involve the transformation of C–F bonds into C–Mg, C–Al, C–Si, C–Fe and C–Zn bonds. We focus on the use of highly reactive main group nucleophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ace8744b599823f867c38fbcbac6c8
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
sp3C−F Bonds of fluoroalkanes (7 examples; 1°, 2° and 3°) undergo addition to a low‐valent Mg−Mg species generating reactive organomagnesium reagents. Further reactions with a series of electrophiles results in a net C−F to C−B, C−Si,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95c2043af171fbf26c7797a76e20b4ad
https://pubmed.ncbi.nlm.nih.gov/30207410
https://pubmed.ncbi.nlm.nih.gov/30207410
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 283(4)
We studied the effect of the antihyperglycemic glitazones, ciglitazone, troglitazone, and rosiglitazone, on glutamine metabolism in renal tubule-derived Madin-Darby canine kidney (MDCK) cells. Troglitazone (25 μM) enhanced glucose uptake and lactate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9e9dfdcf9e1ca4f590c229b0b6c6bd
https://pubmed.ncbi.nlm.nih.gov/12217890
https://pubmed.ncbi.nlm.nih.gov/12217890