Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Greg C, Rigdon"'
Autor:
Michael D. Aleo, Jiri Aubrecht, Paul D. Bonin, Deborah A. Burt, Jennifer Colangelo, Lina Luo, Shelli Schomaker, Rachel Swiss, Simon Kirby, Greg C. Rigdon, Pinky Dua
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 1, Pp n/a-n/a (2019)
Abstract During a randomized Phase 1 clinical trial the drug candidate, PF‐04895162 (ICA‐105665), caused transaminase elevations (≥grade 1) in six of eight healthy subjects treated at 300 mg twice daily for 2‐weeks (NCT01691274). This was une
Externí odkaz:
https://doaj.org/article/1c3b4feee3294f4685dafba7fa2a28f4
Autor:
Shelli J. Schomaker, Pinky Dua, Lina Luo, Jennifer Colangelo, Greg C. Rigdon, Rachel Swiss, Simon Kirby, Jiri Aubrecht, Michael D. Aleo, Deborah A. Burt, Paul D. Bonin
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 7, Iss 1, Pp n/a-n/a (2019)
Pharmacology Research & Perspectives, Vol 7, Iss 1, Pp n/a-n/a (2019)
During a randomized Phase 1 clinical trial the drug candidate, PF‐04895162 (ICA‐105665), caused transaminase elevations (≥grade 1) in six of eight healthy subjects treated at 300 mg twice daily for 2‐weeks (NCT01691274). This was unexpected s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe4796207cf58d755785084f24488e8
https://pubmed.ncbi.nlm.nih.gov/30784208
https://pubmed.ncbi.nlm.nih.gov/30784208
Autor:
William E. Rosenfeld, Bree DiVentura, Bassel Abou-Khalil, Dorothée G.A. Kasteleijn-Nolst Trenité, Seth Hetherington, Elizabeth Moore, Greg C. Rigdon, Jacqueline A. French, Victor Biton
Publikováno v:
Epilepsia
ICA-105665, identified by Icagen, Inc. (Durham, NC, U.S.A.), is a novel small molecule that opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels (Roeloffs et al., 12), also known as KCNQ2/3 and KCNQ3/5 channels. The compound has demonstrated broad spectr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718f48f6c59158a02a381529494c4af3
https://doi.org/10.1111/epi.12224
https://doi.org/10.1111/epi.12224
Autor:
James O. McNamara, Greg C. Rigdon, Grant Andrew Mcnaughton-Smith, Stephen Werness, Rosemarie Roeloffs, James Stables, Christopher Crean, Neil Ghodadra, Alan D. Wickenden
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:818-828
Openers or activators of neuronal KCNQ2/Q3 potassium channels decrease neuronal excitability and may provide benefit in the treatment of disorders of neuronal excitability such as epilepsy. In the present study, we evaluate the effects of ICA-27243 [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9a79df4148149c3a089dafe0ea650a
https://doi.org/10.1124/jpet.108.137794
https://doi.org/10.1124/jpet.108.137794
Autor:
Kenneth I. Ataga, Jonathan W. Stacker, Greg C. Rigdon, Yogen Saunthararajah, Paul Swerdlow, E. Vichinsky, Eugene P. Orringer, Abdullah Kutlar, Laura M. De Castro, Wally R. Smith, Oswaldo Castro
Publikováno v:
Blood. 111:3991-3997
Senicapoc, a novel Gardos channel inhibitor, limits solute and water loss, thereby preserving sickle red blood cell (RBC) hydration. Because hemoglobin S polymerization is profoundly influenced by intracellular hemoglobin concentration, senicapoc cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b72f28807c0602f9bacdf293741f349a
https://doi.org/10.1182/blood-2007-08-110098
https://doi.org/10.1182/blood-2007-08-110098
Publikováno v:
Expert Opinion on Therapeutic Patents. 14:457-469
Epilepsy and neuropathic pain are disorders characterised by excessive neuronal activity. These disorders are currently managed by drugs that are capable of dampening neuronal excitability, including voltage-gated sodium channel blockers, voltage-ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ae09f4d2ed2aaee47f353f396921e3
https://doi.org/10.1517/13543776.14.4.457
https://doi.org/10.1517/13543776.14.4.457
Autor:
Gregory J. Kato, Jonathan W. Stocker, Alan T. Remaley, Jonathan Wilson, Greg C. Rigdon, Caterina P. Minniti, Laurel Mendelsohn
Publikováno v:
British Journal of Haematology. 155:634-636
Dear Editor: The Gardos channel inhibitor senicapoc is proven to diminish haemolytic anaemia in a Phase II study conducted in adults with sickle cell anaemia (Ataga, et al 2008), and later confirmed in a Phase III study in sickle cell disease subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9bc23f4c1b1f4fd2c0f9a190df4776b
https://doi.org/10.1111/j.1365-2141.2011.08757.x
https://doi.org/10.1111/j.1365-2141.2011.08757.x
Autor:
Philip W. Scates, Morton Harfenist, Jane Croft Harrelson, John E. Hughes, Ron M. Norton, Helen L. White, Barrett R. Cooper, Greg C. Rigdon, Thomas E. Johnson, Stacey A. Jones
Publikováno v:
Drug Development Research. 45:1-9
2614W94 [3-(1-trifluoromethyl)ethoxyphenoxathiin 10,10-dioxide] is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and a Ki value of 1.6 nM with serotonin as substrate. In pretreated rats, the ED50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44a25e0b5600923f48269e88d37572b4
https://doi.org/10.1002/(sici)1098-2299(199809)45:1<1::aid-ddr1>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199809)45:1<1::aid-ddr1>3.0.co
Autor:
Virginia M. Boncek, James L. Howard, Greg C. Rigdon, Gerald T. Pollard, Barrett R. Cooper, Mark H. Norman, Walter L Faison, Kevin P. Nanry
Publikováno v:
Neuropsychopharmacology. 15:231-242
1192U90 was developed on the assumption that antagonism of 5-HT2 receptors efficacy yields more potently than D2 receptors against positive and negative symptoms of schizophrenia with minimal liability for extrapyramidal side effects (EPSs), and that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2b4402d620dd5a9ecb394731b2f749
https://doi.org/10.1016/0893-133x(95)00239-a
https://doi.org/10.1016/0893-133x(95)00239-a
Publikováno v:
Life Sciences. 57:PL275-PL283
Binding of 3H-spiperone and 3H-raclopride to membranes of cells stably-transfected with a human dopamine D2 receptor clone was investigated, as was that of 3H-spiperone to those stably-transfected with a human D4 receptor clone. 3H-spiperone and 3H-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e6b795b2b3d5bbe8d7fede56a67446
https://doi.org/10.1016/0024-3205(95)02151-8
https://doi.org/10.1016/0024-3205(95)02151-8