Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Greg Buhrman"'
Publikováno v:
Data in Brief, Vol 6, Iss , Pp 423-427 (2016)
This article expands on crystal structure data for human H-RAS with mutations at position Y137, briefly described in a paper on the effects of phosphorylation of Y137 by ABL kinases (Tyrosine phosphorylation of RAS by ABL allosterically enhances effe
Externí odkaz:
https://doaj.org/article/e1f4c5fa290c4bfebc66c15af6809fb9
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168022 (2016)
Bacterial α-carbonic anhydrases (α-CA) are zinc containing metalloenzymes that catalyze the rapid interconversion of CO2 to bicarbonate and a proton. We report the first crystal structure of a pyschrohalophilic α-CA from a deep-sea bacterium, Phot
Externí odkaz:
https://doaj.org/article/451a8bc438184496add57a5a8b53d117
Autor:
Hayden Baer, Paul Enríquez, Robert B. Rose, Greg Buhrman, Amy M. Grunden, Vivian Truong, Lucas Dillard
Publikováno v:
Biochemistry. 60:324-345
2-Oxoglutarate carboxylase (OGC), a unique member of the biotin-dependent carboxylase family from the order Aquificales, captures dissolved CO2 via the reductive tricarboxylic acid (rTCA) cycle. Structure and function studies of OGC may facilitate ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc07e95f62696a87b937087264734599
https://doi.org/10.1021/acs.biochem.0c00815
https://doi.org/10.1021/acs.biochem.0c00815
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::476c5638dac8359c7a8cba1887bf9dc9
https://doi.org/10.1096/fasebj.2022.36.s1.r5043
https://doi.org/10.1096/fasebj.2022.36.s1.r5043
Autor:
Greg, Buhrman, Paul, Enríquez, Lucas, Dillard, Hayden, Baer, Vivian, Truong, Amy M, Grunden, Robert B, Rose
Publikováno v:
Biochemistry. 60(4)
2-Oxoglutarate carboxylase (OGC), a unique member of the biotin-dependent carboxylase family from the order Aquificales, captures dissolved CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d0aa3618b4baf1c1caa2689bf2536fb
https://pubmed.ncbi.nlm.nih.gov/33464881
https://pubmed.ncbi.nlm.nih.gov/33464881
Autor:
Thierry Olivry, Robert Goggs, Theresa O'Toole, Lorna J. Kennedy, Robert B. Rose, Natasha J. Olby, Greg Buhrman, Lhoucine Chdid, Steven G. Friedenberg, Julien Guillaumin, Kathryn M. Meurs
Publikováno v:
Friedenberg, S G, Buhrman, G, Chdid, L, Olby, N J, Olivry, T, Guillaumin, J, O'Toole, T, Goggs, R, Kennedy, L J, Rose, R B & Meurs, K M 2016, ' Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs ', Immunogenetics, vol. 68, no. 3, pp. 205-17 . https://doi.org/10.1007/s00251-015-0894-6
Immune-mediated diseases are common and life-threatening disorders in dogs. Many canine immune-mediated diseases have strong breed predispositions and are believed to be inherited. However, the genetic mutations that cause these diseases are mostly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323e8e2c6cbe3fcdc5f2c94bf29c08d3
https://doi.org/10.1007/s00251-015-0894-6
https://doi.org/10.1007/s00251-015-0894-6
Publikováno v:
Biochemistry. 51:6114-6126
Ras GTPase cycles between its active GTP-bound form promoted by GEFs and its inactive GDP-bound form promoted by GAPs to affect the control of various cellular functions. It is becoming increasingly apparent that subtle regulation of the GTP-bound ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc444b0646affd76320e2fb400b975f
https://doi.org/10.1021/bi300509j
https://doi.org/10.1021/bi300509j
Publikováno v:
Proceedings of the National Academy of Sciences. 107:4931-4936
Ras and its effector Raf are key mediators of the Ras/Raf/MEK/ERK signal transduction pathway. Mutants of residue Q61 impair the GTPase activity of Ras and are found prominently in human cancers. Yet the mechanism through which Q61 contributes to cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff983e4298d5a3a73acae9ced9146585
https://doi.org/10.1073/pnas.0912226107
https://doi.org/10.1073/pnas.0912226107
Publikováno v:
Structure. 15(12):1618-1629
Summary Transformation efficiencies of Ras mutants at residue 61 range over three orders of magnitude, but the in vitro GTPase activity decreases 10-fold for all mutants. We show that Raf impairs the GTPase activity of RasQ61L, suggesting that the Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de94cb71ed7bf07316863579da08a567
Publikováno v:
Biochemistry. 44:5307-5316
Cdc25B phosphatase, an important regulator of the cell cycle, forms an intramolecular disulfide bond in response to oxidation leading to reversible inactivation of phosphatase activity. We have obtained a crystallographic time course revealing the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820e9d7745cc2c584ddd970c03844ec1
https://doi.org/10.1021/bi047449f
https://doi.org/10.1021/bi047449f