Activity of the Lactate Dehydrogenase Inhibitor Oxamic Acid against the Fermentative Bacterium Streptococcus mitis/oralis: Bactericidal Effects and Prevention of Daptomycin Resistance In Vitro and in an Ex Vivo Model

Autor: Razieh Kebriaei, Arnold S. Bayer, Christian K. Lapitan, Michael J. Rybak, Greg A. Somerville, Nagendra N. Mishra

Publikováno v: Antibiotics, Vol 11, Iss 10, p 1409 (2022)

Streptococcus mitis/oralis is a fermentative bacterium that relies on lactate dehydrogenase to balance its redox poise and keep glycolysis active. Metabolomic analysis of an in vitro–derived daptomycin-resistant (DAP-R) S. mitis/oralis strain (351-

Externí odkaz: https://doaj.org/article/99075caa05b94773aea42233553ca68e

CcpA Affects Infectivity of Staphylococcus aureus in a Hyperglycemic Environment

Autor: Markus Bischoff, Bodo Wonnenberg, Nadine Nippe, Naja J. Nyffenegger-Jann, Meike Voss, Christoph Beisswenger, Cord Sunderkötter, Virginie Molle, Quoc Thai Dinh, Frank Lammert, Robert Bals, Mathias Herrmann, Greg A. Somerville, Thomas Tschernig, Rosmarie Gaupp

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

Many bacteria regulate the expression of virulence factors via carbon catabolite responsive elements. In Gram-positive bacteria, the predominant mediator of carbon catabolite repression is the catabolite control protein A (CcpA). Hyperglycemia is a w

Externí odkaz: https://doaj.org/article/10c125fbe3364c27a5cde493ae5fcbeb

A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β-Lactam Stress

Autor: Vinai Chittezham Thomas, Lauren C. Kinkead, Ashley Janssen, Carolyn R. Schaeffer, Keith M. Woods, Jill K. Lindgren, Jonathan M. Peaster, Sujata S. Chaudhari, Marat Sadykov, Joselyn Jones, Sameh M. Mohamadi AbdelGhani, Matthew C. Zimmerman, Kenneth W. Bayles, Greg A. Somerville, Paul D. Fey

Publikováno v: mBio, Vol 4, Iss 4 (2013)

ABSTRACT A recent controversial hypothesis suggested that the bactericidal action of antibiotics is due to the generation of endogenous reactive oxygen species (ROS), a process requiring the citric acid cycle (tricarboxylic acid [TCA] cycle). To test

Externí odkaz: https://doaj.org/article/0e957108156f4ea585a2b4484c5cb040

1703. Efficacy of Selected Metabolic Inhibitors for the Prevention and Resensitization of High-Level Daptomycin Resistance in Streptococcus mitis-oralis In Vitro and in an Ex Vivo Simulated Endocarditis Model

Autor: Razieh Kebriaei, Michael J Rybak, Christian K Lapitan, Greg A Somerville, Arnold S Bayer, Nagendra N Mishra

Publikováno v: Open Forum Infectious Diseases. 9

Background Rapid development of stable, high-level daptomycin-resistance (DAP-R) is frequent among Streptococcus mitis-oralis strains during exposure to DAP in vitro and in vivo. Metabolomic analyses of in vitro-derived daptomycin-resistant (DAP-R) S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e5b05d616dc5378deb92484cde1446f
https://doi.org/10.1093/ofid/ofac492.1333

Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase

Autor: Emily Stevens, Stewart G. Gardner, Ruth C. Massey, Maisem Laabei, Greg A. Somerville

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Stevens, E, Massey, R, Laabei, M, Gardner, S & Somerville, G 2017, ' Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase ', Scientific Reports, vol. 7, 13744 . https://doi.org/10.1038/s41598-017-14110-8
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80feb1a2867e0368255ca73b3645ad50
http://hdl.handle.net/2072/430769