Zobrazeno 1 - 10
of 1 008
pro vyhledávání: '"Greg A. GERHARDT"'
Publikováno v:
Applied Biosciences, Vol 3, Iss 2, Pp 233-249 (2024)
Synucleinopathies, typified by Parkinson’s disease (PD), entail the accumulation of α-synuclein (αSyn) aggregates in nerve cells. Various αSyn mutants, including the αSyn A53T variant linked to early-onset PD, increase the propensity for αSyn
Externí odkaz:
https://doaj.org/article/ade13e66a872485da1b5aba260373c93
Autor:
Monica J. Chau, Jorge E. Quintero, Paula V. Monje, Stephen Randal Voss, Andrew S. Welleford, Greg A. Gerhardt, Craig G. van Horne
Publikováno v:
Cell Transplantation, Vol 31 (2022)
One promising strategy in cell therapies for Parkinson’s disease (PD) is to harness a patient’s own cells to provide neuroprotection in areas of the brain affected by neurodegeneration. No treatment exists to replace cells in the brain. Thus, our
Externí odkaz:
https://doaj.org/article/cc5d443f2bf44dee96518626a9bbc0a6
Autor:
Monica J. Chau, Jorge E. Quintero, Eric Blalock, Stephanie Byrum, Samuel G. Mackintosh, Christopher Samaan, Greg A. Gerhardt, Craig G. van Horne
Publikováno v:
PLoS ONE, Vol 17, Iss 11 (2022)
Regeneration after severe peripheral nerve injury is often poor. Knowledge of human nerve regeneration and the growth microenvironment is greatly lacking. We aimed to identify the regenerative proteins in human peripheral nerve by comparing the prote
Externí odkaz:
https://doaj.org/article/54540cc354fd48a1a69d56664db87924
Autor:
Andrew S. Welleford, Jorge E. Quintero, Nader El Seblani, Eric Blalock, Sumedha Gunewardena, Steven M. Shapiro, Sean M. Riordan, Peter Huettl, Zain Guduru, John A. Stanford, Craig G. van Horne, Greg A. Gerhardt
Publikováno v:
Cell Transplantation, Vol 29 (2020)
The development of regenerative therapies for central nervous system diseases can likely benefit from an understanding of the peripheral nervous system repair process, particularly in identifying potential gene pathways involved in human nerve repair
Externí odkaz:
https://doaj.org/article/56eb83084feb4d8a8553003ca5a0c73c
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Spreading depolarization (SD) is a slow propagating wave of strong depolarization of neural cells, implicated in several neuropathological conditions. The breakdown of brain homeostasis promotes significant hemodynamic and metabolic alterati
Externí odkaz:
https://doaj.org/article/bba8403e168b4ea4bb2a7b8d57b7fc63
Autor:
Geetanjali Gera, Zain Guduru, Tritia Yamasaki, Julie A. Gurwell, Monica J. Chau, Anna Krotinger, Frederick A. Schmitt, John T. Slevin, Greg A. Gerhardt, Craig van Horne, Jorge E. Quintero
Publikováno v:
Brain Sciences, Vol 11, Iss 4, p 500 (2021)
Background: The efficacy of deep brain stimulation (DBS) and dopaminergic therapy is known to decrease over time. Hence, a new investigational approach combines implanting autologous injury-activated peripheral nerve grafts (APNG) at the time of bila
Externí odkaz:
https://doaj.org/article/51470d7840ee473b825c3711050ad64e
Autor:
Martin Lundblad, David A. Price, Jason J. Burmeister, Jorge E. Quintero, Peter Huettl, Francois Pomerleau, Nancy R. Zahniser, Greg A. Gerhardt
Publikováno v:
Applied Sciences, Vol 10, Iss 18, p 6449 (2020)
Here we report a novel microelectrode array recording approach to measure tonic (resting) and phasic release of dopamine (DA) in DA-rich areas such as the rat striatum and nucleus accumbens. The resulting method is tested in intact central nervous sy
Externí odkaz:
https://doaj.org/article/9699d130393440148e789f8933cec301
Publikováno v:
Micromachines, Vol 11, Iss 7, p 632 (2020)
The intracranial measurement of local cerebral tissue oxygen levels—PbtO2—has become a useful tool for the critical care unit to investigate severe trauma and ischemia injury in patients. Our preliminary work in animal models supports the hypothe
Externí odkaz:
https://doaj.org/article/fba93e84d9af4e25afec63bb0eb7e2e8
Autor:
P. Justin eRossi, Aysegul eGunduz, Jack eJudy, Linda eWilson, Andre eMachado, James J Giordano, W. Jeff eElias, Ron L. Alterman, Marvin A. Rossi, Christopher L. Butson, Michael D Fox, Cameron C. McIntyre, Nader ePouratian, Nicole C. Swann, Coralie ede Hemptinne, Robert E. Gross, Howard J. Chizeck, Michele eTagliati, Andres M. Lozano, Wayne eGoodman, Jean-Philippe eLangevin, Umer eAkbar, Greg A. Gerhardt, Warren M Grill, Mark eHallett, Todd eHerrington, Jeffrey eHerron, Craig evan Horne, Brian H. Kopell, Anthony E. Lang, Codrin eLungu, Daniel eMartinez-Ramirez, Alon Y. Mogilner, Rene eMolina, Enrico eOpri, Kevin J. Otto, Karim G. Oweiss, Yagna ePathak, Aparna eShukla, Jonathan eShute, Sameer A. Sheth, Ludy C. Shih, G. Karl eSteinke, Alexander I. Tröster, Nora eVanegas, Kareem eZaghloul, Leopoldo eCendejas-Zaragoza, Leonard eVerhagen, Kelly Douglas Foote, Michael S. Okun
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
This review summarizes the most contemporary clinical, electrophysiological, imaging, and computational work on DBS for the treatment of neurological and neuropsychiatric disease. Significant innovations of the past year are emphasized; these advance
Externí odkaz:
https://doaj.org/article/8f5c76e3b6ad4a97a45c798a9a470025
Autor:
Liming Luan, Feng Ding, Yi Ai, Anders Andersen, Peter Hardy, Eric Forman, Greg A. Gerhardt, Don M. Gash, Richard Grondin, Zhiming Zhang
Publikováno v:
Cell Transplantation, Vol 17 (2008)
There is a great need for the development of noninvasive, highly sensitive, and widely available imaging methods that can potentially be used to longitudinally monitor treatment of Parkinson's disease (PD). Here we report the monitoring of GDNF-induc
Externí odkaz:
https://doaj.org/article/e034b8b26ab844eebf59f87315be1470