Zobrazeno 1 - 10
of 919
pro vyhledávání: '"Greg A, Gerhardt"'
Publikováno v:
Applied Biosciences, Vol 3, Iss 2, Pp 233-249 (2024)
Synucleinopathies, typified by Parkinson’s disease (PD), entail the accumulation of α-synuclein (αSyn) aggregates in nerve cells. Various αSyn mutants, including the αSyn A53T variant linked to early-onset PD, increase the propensity for αSyn
Externí odkaz:
https://doaj.org/article/ade13e66a872485da1b5aba260373c93
Autor:
Monica J. Chau, Jorge E. Quintero, Paula V. Monje, Stephen Randal Voss, Andrew S. Welleford, Greg A. Gerhardt, Craig G. van Horne
Publikováno v:
Cell Transplantation, Vol 31 (2022)
One promising strategy in cell therapies for Parkinson’s disease (PD) is to harness a patient’s own cells to provide neuroprotection in areas of the brain affected by neurodegeneration. No treatment exists to replace cells in the brain. Thus, our
Externí odkaz:
https://doaj.org/article/cc5d443f2bf44dee96518626a9bbc0a6
Autor:
Christopher J McLouth, Jorge E Quintero, John T Slevin, Julie A Gurwell, Riham El Khouli, Monica J Chau, Zain Guduru, Greg A Gerhardt, Craig G van Horne
Publikováno v:
BMJ Neurology Open, Vol 4, Iss 2 (2022)
Objective To evaluate the interim feasibility, safety and clinical measures data of direct delivery of regenerating peripheral nerve tissue (PNT) to the substantia nigra (SN) in participants with Parkinson’s disease (PD).Methods Eighteen (13 men/5
Externí odkaz:
https://doaj.org/article/60d64d19d8ea4e2d82701d44a6764bb8
Autor:
Monica J Chau, Jorge E Quintero, Eric Blalock, Stephanie Byrum, Samuel G Mackintosh, Christopher Samaan, Greg A Gerhardt, Craig G van Horne
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0260998 (2022)
Regeneration after severe peripheral nerve injury is often poor. Knowledge of human nerve regeneration and the growth microenvironment is greatly lacking. We aimed to identify the regenerative proteins in human peripheral nerve by comparing the prote
Externí odkaz:
https://doaj.org/article/533e2015c6aa4c3286b004feda193875
Autor:
Jaimie Hixson, Jorge E. Quintero, Ashley Guiliani, Tritia R. Yamasaki, Greg A. Gerhardt, John T. Slevin, Craig G. van Horne
Publikováno v:
Journal of Parkinson's Disease. 13:421-426
We sought to design a data visualization platform to represent the Movement Disorder Society- Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) item scores in an easy-to-use display without modification of the raw data or summary scores. Score i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1e23c9ba75c8b33dcfd8e82899cbce3
https://doi.org/10.3233/jpd-225071
https://doi.org/10.3233/jpd-225071
Autor:
Andrew S. Welleford, Jorge E. Quintero, Nader El Seblani, Eric Blalock, Sumedha Gunewardena, Steven M. Shapiro, Sean M. Riordan, Peter Huettl, Zain Guduru, John A. Stanford, Craig G. van Horne, Greg A. Gerhardt
Publikováno v:
Cell Transplantation, Vol 29 (2020)
The development of regenerative therapies for central nervous system diseases can likely benefit from an understanding of the peripheral nervous system repair process, particularly in identifying potential gene pathways involved in human nerve repair
Externí odkaz:
https://doaj.org/article/56eb83084feb4d8a8553003ca5a0c73c
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Spreading depolarization (SD) is a slow propagating wave of strong depolarization of neural cells, implicated in several neuropathological conditions. The breakdown of brain homeostasis promotes significant hemodynamic and metabolic alterati
Externí odkaz:
https://doaj.org/article/bba8403e168b4ea4bb2a7b8d57b7fc63
Autor:
Geetanjali Gera, Zain Guduru, Tritia Yamasaki, Julie A. Gurwell, Monica J. Chau, Anna Krotinger, Frederick A. Schmitt, John T. Slevin, Greg A. Gerhardt, Craig van Horne, Jorge E. Quintero
Publikováno v:
Brain Sciences, Vol 11, Iss 4, p 500 (2021)
Background: The efficacy of deep brain stimulation (DBS) and dopaminergic therapy is known to decrease over time. Hence, a new investigational approach combines implanting autologous injury-activated peripheral nerve grafts (APNG) at the time of bila
Externí odkaz:
https://doaj.org/article/51470d7840ee473b825c3711050ad64e
Autor:
Zachary D. Kelley, Bert C. Lynn, Dennis T. Rogers, Greg A. Gerhardt, John M. Littleton, Francois Pomerleau, Dustin Brown
Publikováno v:
J Biotechnol
The dopamine transporter (DAT) is targeted in substance use disorders (SUDs), and "non-classical”" DAT inhibitors with low abuse potential are therapeutic candidates. Lobinaline, from Lobelia cardinalis, is an atypical DAT inhibitor lead. Chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2348ecb668ae05e6021aa57bf177b778
https://doi.org/10.1016/j.jbiotec.2021.10.001
https://doi.org/10.1016/j.jbiotec.2021.10.001
Autor:
Martin Lundblad, David A. Price, Jason J. Burmeister, Jorge E. Quintero, Peter Huettl, Francois Pomerleau, Nancy R. Zahniser, Greg A. Gerhardt
Publikováno v:
Applied Sciences, Vol 10, Iss 18, p 6449 (2020)
Here we report a novel microelectrode array recording approach to measure tonic (resting) and phasic release of dopamine (DA) in DA-rich areas such as the rat striatum and nucleus accumbens. The resulting method is tested in intact central nervous sy
Externí odkaz:
https://doaj.org/article/9699d130393440148e789f8933cec301