Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Greg, Hollis"'
Autor:
Holly Koblish, Yun-Long Li, Niu Shin, Leslie Hall, Qian Wang, Kathy Wang, Maryanne Covington, Cindy Marando, Kevin Bowman, Jason Boer, Krista Burke, Richard Wynn, Alex Margulis, Gary W Reuther, Que T Lambert, Valerie Dostalik Roman, Ke Zhang, Hao Feng, Chu-Biao Xue, Sharon Diamond, Greg Hollis, Swamy Yeleswaram, Wenqing Yao, Reid Huber, Kris Vaddi, Peggy Scherle
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199108 (2018)
The Proviral Integration site of Moloney murine leukemia virus (PIM) serine/threonine protein kinases are overexpressed in many hematologic and solid tumor malignancies and play central roles in intracellular signaling networks important in tumorigen
Externí odkaz:
https://doaj.org/article/171a9a5db0614099bf5185681e8619f9
Autor:
J. Dale Roberts, Geoffrey W. Heard, Simon Clulow, Jean-Marc Hero, Skye Wassens, Ben C. Scheele, Stephen T. Garnett, Greg Hollis, E. P. Vanderduys, David J. Hunter, Emily P. Hoffmann, Michael M. Driessen, Nicola J. Mitchell, Deborah S. Bower, Harry B. Hines, David A. Newell, Graeme R. Gillespie, John C. Z. Woinarski, Conrad J. Hoskin, Hayley M. Geyle, Renee A. Catullo, Michael Mahony, Gerry Marantelli, Frank Lemckert, Katrina Daniels, Matt West, Deon Gilbert, Keith R. Mcdonald, Michael P. Scroggie
Publikováno v:
Pacific Conservation Biology. 28:211-223
More than a third of the world’s amphibian species are listed as Threatened or Extinct, with a recent assessment identifying 45 Australian frogs (18.4% of the currently recognised species) as ‘Threatened’ based on IUCN criteria. We applied stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d823a80302589b1d1176820744b8f8
https://doi.org/10.1071/pc21019
https://doi.org/10.1071/pc21019
Autor:
Qian Wang, Sybil O'Connor, Alan Roberts, Brian W. Metcalf, Leslie Hall, Maxim Soloviev, Michael Hansbury, Greg Hollis, Xin He, Matthew C. Stubbs, Niu Shin, Wenqing Yao, Kamna Katiyar, Phillip C.C. Liu, Kathy Wang, Sharon Diamond, Brent Douty, Gengjie Yang, Dana Shuey, Maryanne B. Covington, Paul Collier, Mingming Gao, Patricia Feldman, Peggy Scherle, Timothy Burn, Andrew P. Combs, Yun-Long Li, Lynn Leffet, Robert C. Newton, Paul Waeltz, Holly Koblish, Jin Lu, Swamy Yeleswaram, Yanlong Li, Reid Huber, Robert Collins, Eddy W. Yue
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:211-222
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)δ inhibitors in B-cell malignancies is hampered by hepatotoxicity, requiring dose reduction, treatment interruption, and/or discontinuation of therapy. In addition, potential molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450ddea425cecfdf40bf1184c7e8c723
https://doi.org/10.1124/jpet.120.265538
https://doi.org/10.1124/jpet.120.265538
Autor:
Niu, Shin, Matthew, Stubbs, Holly, Koblish, Eddy W, Yue, Maxim, Soloviev, Brent, Douty, Kathy He, Wang, Qian, Wang, Mingming, Gao, Patricia, Feldman, Gengjie, Yang, Leslie, Hall, Michael, Hansbury, Sybil, O'Connor, Lynn, Leffet, Robert, Collins, Kamna, Katiyar, Xin, He, Paul, Waeltz, Paul, Collier, Jin, Lu, Yun-Long, Li, Yanlong, Li, Phillip C C, Liu, Timothy, Burn, Maryanne, Covington, Sharon, Diamond, Dana, Shuey, Alan, Roberts, Swamy, Yeleswaram, Greg, Hollis, Brian, Metcalf, Wenqing, Yao, Reid, Huber, Andrew, Combs, Robert, Newton, Peggy, Scherle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(1)
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14a526e7b4c814d8f260a1bead68f92f
https://pubmed.ncbi.nlm.nih.gov/32345620
https://pubmed.ncbi.nlm.nih.gov/32345620
Autor:
Brian Metcalf, Sharon Diamond, Taisheng Huang, Lixin Shao, Swamy Yeleswaram, D. Joseph Rogier, Greg Hollis, Michael Xia, Ke Zhang, Ganfeng Cao, Nancy Contel, Lingquan Kong, Peggy Scherle, Maryanne Covington, Tom Emm, Robert Hughes, Joseph Glenn, Robert C. Newton, Kris Vaddi, Changsheng Zheng, Lou Storace, Chu-Biao Xue, Rajan Anand, Hao Feng, Meloni David, Anlai Wang, Mei Li, Philip A. Morton, Robinson Darius J, Qi Han, Rajesh V. Devraj, Yingxin Zhang
Publikováno v:
ACS Medicinal Chemistry Letters. 2:913-918
We report the discovery of a new (S)-3-aminopyrrolidine series of CCR2 antagonists. Structure-activity relationship studies on this new series led to the identification of 17 (INCB8761/PF-4136309) that exhibited potent CCR2 antagonistic activity, hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2a792b5ba70daa3c854d4e609b3ad5
https://doi.org/10.1021/ml200199c
https://doi.org/10.1021/ml200199c
Autor:
Que T. Lambert, Kevin Bowman, Jason Boer, Gary W. Reuther, Valerie Roman, Peggy Scherle, Reid Huber, Krista Burke, Leslie Hall, Chu-Biao Xue, Kris Vaddi, Niu Shin, Yun-Long Li, Sharon Diamond, Alex Margulis, Qian Wang, Maryanne Covington, Greg Hollis, Swamy Yeleswaram, Holly Koblish, Hao Feng, Wenqing Yao, Cindy A. Marando, Richard Wynn, Ke Zhang, Kathy Wang
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199108 (2018)
PLoS ONE
PLoS ONE
The Proviral Integration site of Moloney murine leukemia virus (PIM) serine/threonine protein kinases are overexpressed in many hematologic and solid tumor malignancies and play central roles in intracellular signaling networks important in tumorigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a13c3f135485d7c8617d5925c8861a
https://doi.org/10.1371/journal.pone.0199108
https://doi.org/10.1371/journal.pone.0199108
Autor:
Boshan Liao, Karen L. Schlingmann, Reid M. Huber, Mark D. Stow, Tim C. Burn, Phillip C Liu, Ranjan Mukherjee, Peter R. Young, Greg Hollis, John Link, Paul M. Collier
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 85:71-79
The peroxisome proliferator activated receptor alpha (PPARalpha) plays a key role in regulating fatty acid metabolism by regulating expression of genes involved in fatty acid oxidation. To identify endogenous transcripts that could be used as surroga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dd3ce6f8a505fa05230eaccc8d6735
https://doi.org/10.1016/s0960-0760(03)00135-3
https://doi.org/10.1016/s0960-0760(03)00135-3
Publikováno v:
Emergency medicine Australasia : EMA. 23(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b2c464c63c69a2a6a7ba8b8fa4c04b0
https://pubmed.ncbi.nlm.nih.gov/21824321
https://pubmed.ncbi.nlm.nih.gov/21824321
Autor:
Greg Hollis, Changsheng Zheng, Hao Feng, Mei Li, Peggy Scherle, Taisheng Huang, Joseph Glenn, Chu-Biao Xue, Kris Vaddi, Lixin Shao, Brian Metcalf, Tom Emm, Nancy Contel, Ke Zhang, Ganfeng Cao, Dilip P. Modi, Lou Storace, Anlai Wang, Sharon Diamond, Robert C. Newton, Chen Lihua, Steven Friedman, Rajan Anand, Vaqar Sharief, Lingquan Kong, Hiroyuki Tanaka, Meloni David, Maryanne Covington, Michael Xia, Laurine G. Galya, Robinson Darius J, Qi Han, Swamy Yeleswaram, Yingxin Zhang
Publikováno v:
ACS medicinal chemistry letters. 2(6)
We report the identification of 13 (INCB3284) as a potent human CCR2 (hCCR2) antagonist. INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2, an IC50 of 4.7 nM in antagonism of chemotaxis activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdd928778e1596e752bde06658b5662
https://pubmed.ncbi.nlm.nih.gov/24900329
https://pubmed.ncbi.nlm.nih.gov/24900329
Autor:
Anlai Wang, Kris Vaddi, Robert Hughes, Sharon Diamond, Mei Li, Steven Friedman, D. Joseph Rogier, Greg Hollis, Joseph Glenn, Phillip A. Morton, Changsheng Zheng, Niu Shin, Ke Zhang, Ganfeng Cao, Peggy Scherle, Swamy Yeleswaram, Hao Feng, Taisheng Huang, Rajan Anand, Ling Kong, Brian Metcalf, Fred Baribaud, Rajesh V. Devraj, Laurine G. Galya, Maryanne Covington, Robert C. Newton, Chu-Biao Xue, Michael Xia
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(5)
We report the discovery of a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist (3S,4S)-N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]-3-methoxytetrahydro-2H-pyran-4-amine (19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8748c7ed89a54cd646a78460c292b1a0
https://pubmed.ncbi.nlm.nih.gov/21295478
https://pubmed.ncbi.nlm.nih.gov/21295478