Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Greetje Elaut"'
Autor:
Tamara Vanhaecke, Georges Laus, Philippe Bachellier, Dirk Tourwé, Lysiane Richert, Greetje Elaut, Vera Rogiers, Eliane Alexandre
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:400-408
Hydroxamic acid (HA)-based histone deacetylase (HDAC) inhibitors, with trichostatin A (TSA) as the reference compound, are potential antitumoral drugs and show promise in the creation of long-term primary cell cultures. However, their metabolic prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693b655723b070addcc067ae5295d950
https://doi.org/10.1124/jpet.106.116202
https://doi.org/10.1124/jpet.106.116202
Autor:
Joan Albert Vericat, Pilar Prieto, Jean-François Ghersi-Egea, Andrew Worth, Bernhard Ladstetter, Siegfried Morath, W. Steiling, Alessandra Gennari, Anthony Long, Magnus Ingelman-Sundberg, Sharon Munn, Bas J. Blaauboer, Annarita Meneguz, Robert Combes, Beatrice Schaack, Emanuela Testai, Enrico Sabbioni, Michael L. Cunningham, Fred Nagelkerke, Peter Hoet, Olavi Pelkonen, Sandra Coecke, Walter Janssens, José V. Castell, Raffaella Corvi, Brighitta Eletti, Susanne Bremer, Andreas P. Freidig, Jessica Ponti, André Guillouzo, L. Richert, H.J. Ahr, David E. Leahy, M. Monshouwer, Silvia Casati, Thomas Hartung, Charles L. Crespi, Greetje Elaut
Publikováno v:
Europe PubMed Central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac6804e3c0f21ab010c6b8a0757a89b
https://doi.org/10.1177/026119290603400113
https://doi.org/10.1177/026119290603400113
Autor:
Pilar Prieto, Nigel Gensmantel, W. Steiling, Walter Pfaller, Peter Hoet, David E. Leahy, Vera Rogiers, M. Monshouwer, Bas J. Blaauboer, Andreas P. Freidig, Bernhard Ladstetter, Benoit Nemery, Greetje Elaut, Enrico Sabbioni, Johannes J.M. van de Sandt, Stuart J. Freeman, Nick Proctor, Annarita Meneguz, Geert Mannens, Sandra Coecke, Olavi Pelkonen, Vassilios M Kapoulas, Gill Langley, Amin Rostami-Hodjegan
Publikováno v:
Alternatives to Laboratory Animals. 33:147-175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::257d2fc2a803bc2e02d558e7979ee307
https://doi.org/10.1177/026119290503301s15
https://doi.org/10.1177/026119290503301s15
Autor:
Peggy Papeleu, Gabriella Torok, Mathieu Vinken, Vera Rogiers, Georges Laus, Dirk Tourwé, Greetje Elaut
Publikováno v:
Drug Metabolism and Disposition. 30:1320-1328
Phase I biotransformation of Trichostatin A (TSA), a histone deacetylase inhibitor with promising antifibrotic and antitumoral properties, was investigated in rat and human liver microsomes and in suspensions of rat hepatocytes. TSA (50 micro M) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05af97306568b34f8dd9736a1e64d069
https://doi.org/10.1124/dmd.30.12.1320
https://doi.org/10.1124/dmd.30.12.1320
Publikováno v:
Toxicology in Vitro. 15:387-392
Cultures of perivenous (PV) and periportal (PP) hepatocytes could provide suitable in vitro models for studying the zone-specific hepatotoxic potential of xenobiotics. However, it is not known whether cultured PP and PV hepatocytes keep their phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e80e0920e9f96b15b9515c1c4c60a7
https://doi.org/10.1016/s0887-2333(01)00041-8
https://doi.org/10.1016/s0887-2333(01)00041-8
Autor:
Tom Henkens, Rudy Beyaert, Andy Wullaert, Dirk Tourwé, Georges Laus, Peggy Papeleu, Mathieu Vinken, Greetje Elaut, Tamara Vanhaecke, Vera Rogiers
Objective: Benzoylaminoalkanohydroxamic acids, including 5‐(4‐dimethylaminobenzoyl)aminovaleric acid hydroxamide (4‐Me(2)N‐BAVAH), are structural analogues of Trichostatin A, a naturally occurring histone deacetylase inhibitor (HDACi). 4‐Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b0086b38015d7eb12ab55b1bff7eba
https://europepmc.org/articles/PMC6496027/
https://europepmc.org/articles/PMC6496027/
Publikováno v:
Vrije Universiteit Brussel
Protein acetylation, catalyzed by the opposing activities of histone deacetylases (HDAC) and histone acetyltransferases, is now recognized to be an important epigenetic modulator of gene transcriptional activity and cell function. As a result of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e82deba41b63ca1281d04447fc9845
https://biblio.vub.ac.be/vubir/the-pharmaceutical-potential-of-histone-deacetylase-inhibitors(3bfd2b66-3d4e-483f-8553-3e050bad93d4).html
https://biblio.vub.ac.be/vubir/the-pharmaceutical-potential-of-histone-deacetylase-inhibitors(3bfd2b66-3d4e-483f-8553-3e050bad93d4).html
Autor:
Vera Rogiers, Mathieu Vinken, Sarah Snykers, Peggy Papeleu, Tom Henkens, Greetje Elaut, Tamara Vanhaecke
Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic biotransformation, enzyme induction and inhibition, and (biotransform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15c3d30224d1d8e4dd00d0aff79812a
https://biblio.vub.ac.be/vubir/molecular-mechanisms-underlying-the-dedifferentiation-process-of-isolated-hepatocytes-and-their-cultures(f61cc7e5-a568-4a3d-8461-e77ca7dff9a5).html
https://biblio.vub.ac.be/vubir/molecular-mechanisms-underlying-the-dedifferentiation-process-of-isolated-hepatocytes-and-their-cultures(f61cc7e5-a568-4a3d-8461-e77ca7dff9a5).html
Autor:
Tamara Vanhaecke, Mathieu Vinken, Tom Henkens, Sarah Snykers, Greetje Elaut, Peggy Papeleu, Vera Rogiers
Publikováno v:
Vrije Universiteit Brussel
In this study, the expression levels of key apoptosis-regulating proteins were investigated by Western blot in primary rat hepatocytes during the various steps of their isolation in the presence and absence of trichostatin A (TSA). It was found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::076485dab0f7280f8fa2b666c74db3dd
https://biblio.vub.ac.be/vubir/effects-of-trichostatin-a-on-apoptosisregulating-proteins-during-hepatocyte-isolation(7d738a8e-1ace-4970-aac1-f20a3049e2ac).html
https://biblio.vub.ac.be/vubir/effects-of-trichostatin-a-on-apoptosisregulating-proteins-during-hepatocyte-isolation(7d738a8e-1ace-4970-aac1-f20a3049e2ac).html
Autor:
Mathieu Vinken, Vera Rogiers, Tamara Vanhaecke, Tom Henkens, Greetje Elaut, Peggy Papeleu, Sarah Snykers
Mimicking the in vivo microenvironment is one of the current strategies to maintain liver-specific functionality in primary cultured hepatocytes for long periods. Freshly isolated hepatocytes entrapped in collagen gel type I (collagen gel immobilizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6695fa77d37bd1712ee5825345f72ee6
https://doi.org/10.1385/1-59259-998-2:247
https://doi.org/10.1385/1-59259-998-2:247