Výsledky vyhledávání - "Greet Vanderlinden"

Akademický článek

In vivo PET of synaptic density as potential diagnostic marker for cognitive disorders: prospective comparison with current imaging markers for neuronal dysfunction and relation to symptomatology - study protocol

Autor: Greet Vanderlinden, Charles Carron, Rik Vandenberghe, Mathieu Vandenbulcke, Koen Van Laere

Publikováno v: BMC Medical Imaging, Vol 24, Iss 1, Pp 1-10 (2024)

Abstract Background 18F-FDG brain PET is clinically used for differential diagnosis in cognitive dysfunction of unclear etiology and for exclusion of a neurodegenerative cause in patients with cognitive impairment in late-life psychiatric disorders.

Externí odkaz: https://doaj.org/article/fb75868cd10c4647b61ca5a17b089bb3

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Long-term test-retest of cerebral [18F]MK-6240 binding and longitudinal evaluation of extracerebral tracer uptake in healthy controls and amnestic MCI patients

Autor: Greet Vanderlinden, Nathalie Mertens, Laura Michiels, Robin Lemmens, Michel Koole, Mathieu Vandenbulcke, Koen Van Laere

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 49:4580-4588

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9d8dc3b8549a0759fd083f56ca098dd
https://doi.org/10.1007/s00259-022-05907-5

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Impact of meningeal uptake and partial volume correction techniques on [18F]MK-6240 binding in aMCI patients and healthy controls

Autor: Nathalie Mertens, Laura Michiels, Greet Vanderlinden, Mathieu Vandenbulcke, Robin Lemmens, Koen Van Laere, Michel Koole

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 42:1236-1246

[18F]MK-6240 is a second-generation tau PET-tracer to quantify neurofibrillary tangles in-vivo. However, individually variable levels of meningeal uptake induce spill-in-effects into the cortex, complicating [18F]MK-6240 PET quantification. Group SUV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::376623394abe9d6eb5fe6183e6622050
https://doi.org/10.1177/0271678x221076023

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Impact of meningeal uptake and partial volume correction techniques on [

Autor: Nathalie, Mertens, Laura, Michiels, Greet, Vanderlinden, Mathieu, Vandenbulcke, Robin, Lemmens, Koen, Van Laere, Michel, Koole

Publikováno v: J Cereb Blood Flow Metab

[(18)F]MK-6240 is a second-generation tau PET-tracer to quantify neurofibrillary tangles in-vivo. However, individually variable levels of meningeal uptake induce spill-in-effects into the cortex, complicating [(18)F]MK-6240 PET quantification. Group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fca29f92b052381d9d5343d1d0a6ac2
https://pubmed.ncbi.nlm.nih.gov/35062837

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Spatial decrease of synaptic density in amnestic mild cognitive impairment follows the tau build-up pattern

Autor: Greet Vanderlinden, Jenny Ceccarini, Thomas Vande Casteele, Laura Michiels, Robin Lemmens, Eric Triau, Kim Serdons, Jos Tournoy, Michel Koole, Mathieu Vandenbulcke, Koen Van Laere

Publikováno v: Molecular psychiatry. 27(10)

Next to amyloid and tau, synaptic loss is a key pathological hallmark in Alzheimer's disease, closely related to cognitive dysfunction and neurodegeneration. Tau is thought to cause synaptic loss, but this has not been experimentally verified in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c383247d366ad43a176d7299a469e1c7
https://pubmed.ncbi.nlm.nih.gov/35794185

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