Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Greet Roef"'
Autor:
Alexander Teumer, Layal Chaker, Stefan Groeneweg, Yong Li, Celia Di Munno, Caterina Barbieri, Ulla T. Schultheiss, Michela Traglia, Tarunveer S. Ahluwalia, Masato Akiyama, Emil Vincent R. Appel, Dan E. Arking, Alice Arnold, Arne Astrup, Marian Beekman, John P. Beilby, Sofie Bekaert, Eric Boerwinkle, Suzanne J. Brown, Marc De Buyzere, Purdey J. Campbell, Graziano Ceresini, Charlotte Cerqueira, Francesco Cucca, Ian J. Deary, Joris Deelen, Kai-Uwe Eckardt, Arif B. Ekici, Johan G. Eriksson, Luigi Ferrrucci, Tom Fiers, Edoardo Fiorillo, Ian Ford, Caroline S. Fox, Christian Fuchsberger, Tessel E. Galesloot, Christian Gieger, Martin Gögele, Alessandro De Grandi, Niels Grarup, Karin Halina Greiser, Kadri Haljas, Torben Hansen, Sarah E. Harris, Diana van Heemst, Martin den Heijer, Andrew A. Hicks, Wouter den Hollander, Georg Homuth, Jennie Hui, M. Arfan Ikram, Till Ittermann, Richard A. Jensen, Jiaojiao Jing, J. Wouter Jukema, Eero Kajantie, Yoichiro Kamatani, Elisa Kasbohm, Jean-Marc Kaufman, Lambertus A. Kiemeney, Margreet Kloppenburg, Florian Kronenberg, Michiaki Kubo, Jari Lahti, Bruno Lapauw, Shuo Li, David C. M. Liewald, Lifelines Cohort Study, Ee Mun Lim, Allan Linneberg, Michela Marina, Deborah Mascalzoni, Koichi Matsuda, Daniel Medenwald, Christa Meisinger, Ingrid Meulenbelt, Tim De Meyer, Henriette E. Meyer zu Schwabedissen, Rafael Mikolajczyk, Matthijs Moed, Romana T. Netea-Maier, Ilja M. Nolte, Yukinori Okada, Mauro Pala, Cristian Pattaro, Oluf Pedersen, Astrid Petersmann, Eleonora Porcu, Iris Postmus, Peter P. Pramstaller, Bruce M. Psaty, Yolande F. M. Ramos, Rajesh Rawal, Paul Redmond, J. Brent Richards, Ernst R. Rietzschel, Fernando Rivadeneira, Greet Roef, Jerome I. Rotter, Cinzia F. Sala, David Schlessinger, Elizabeth Selvin, P. Eline Slagboom, Nicole Soranzo, Thorkild I. A. Sørensen, Timothy D. Spector, John M. Starr, David J. Stott, Youri Taes, Daniel Taliun, Toshiko Tanaka, Betina Thuesen, Daniel Tiller, Daniela Toniolo, Andre G. Uitterlinden, W. Edward Visser, John P. Walsh, Scott G. Wilson, Bruce H. R. Wolffenbuttel, Qiong Yang, Hou-Feng Zheng, Anne Cappola, Robin P. Peeters, Silvia Naitza, Henry Völzke, Serena Sanna, Anna Köttgen, Theo J. Visser, Marco Medici
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH tra
Externí odkaz:
https://doaj.org/article/34ab5dc1d5c54e85877b61677f6ec6a8
Autor:
Hélène De Naeyer, Veerle Bogaert, Annelies De Spaey, Greet Roef, Sara Vandewalle, Wim Derave, Youri Taes, Jean-Marc Kaufman
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86235 (2014)
ObjectiveThe relationship between serum testosterone (T) levels, muscle mass and muscle force in eugonadal men is incompletely understood. As polymorphisms in the androgen receptor (AR) gene cause differences in androgen sensitivity, no straightforwa
Externí odkaz:
https://doaj.org/article/728fd34747704cce9d3045ff1f3b1e3b
Publikováno v:
Acta Clinica Belgica. 77:137-141
Syphilis is a systemic, infectious disease caused byWe report a case of secondary syphilis with thyroid gland and ocular involvement in a human immunodeficiency virus (HIV) negative patient.We present the patient's history, clinical findings, laborat
Autor:
Yolande F. M. Ramos, Tom Fiers, Jari Lahti, Tarunveer S. Ahluwalia, Elisa Kasbohm, Silvia Naitza, Hou-Feng Zheng, Charlotte Cerqueira, Ingrid Meulenbelt, Betina H. Thuesen, Ernst Rietzschel, Anne R. Cappola, John P. Walsh, Alessandro De Grandi, Johan G. Eriksson, Suzanne J. Brown, Jiaojiao Jing, Deborah Mascalzoni, Nicole Soranzo, Daniel Taliun, Margreet Kloppenburg, Purdey J Campbell, Kai-Uwe Eckardt, Yong Li, Mauro Pala, Marco Medici, Florian Kronenberg, Caterina Barbieri, Francesco Cucca, Allan Linneberg, Anna Köttgen, Bruce M. Psaty, Eric Boerwinkle, Ian J. Deary, Jennie Hui, Joris Deelen, Matthijs Moed, Astrid Petersmann, Graziano Ceresini, Michela Marina, Iris Postmus, Alice M. Arnold, Michiaki Kubo, J. Brent Richards, Marc De Buyzere, Henriette E. Meyer zu Schwabedissen, Eleonora Porcu, Christian Fuchsberger, Celia Di Munno, Dan E. Arking, David J. Stott, Toshiko Tanaka, Sofie Bekaert, Andrew A. Hicks, W. Edward Visser, Wouter den Hollander, Martin Gögele, Cinzia Sala, Peter P. Pramstaller, Georg Homuth, Yukinori Okada, Arne Astrup, Arif B. Ekici, Ulla T. Schultheiss, Richard A. Jensen, Christa Meisinger, Romana T. Netea-Maier, Rafael T. Mikolajczyk, Theo J. Visser, Marian Beekman, Michela Traglia, David C. Liewald, Koichi Matsuda, Thorkild I. A. Sørensen, Ilja M. Nolte, André G. Uitterlinden, David Schlessinger, Luigi Ferrrucci, Shuo Li, Alexander Teumer, Daniel Tiller, Sarah E. Harris, J. Wouter Jukema, Rajesh Rawal, Tim De Meyer, Kadri Haljas, Greet Roef, Yoichiro Kamatani, Karin Halina Greiser, Jean-Marc Kaufman, Serena Sanna, Bruce H. R. Wolffenbuttel, Scott Wilson, Daniela Toniolo, Ee Mun Lim, Stefan Groeneweg, Caroline S. Fox, Torben Hansen, Masato Akiyama, Christian Gieger, Layal Chaker, Tim D. Spector, Ian Ford, Martin den Heijer, P. Eline Slagboom, Elizabeth Selvin, Lambertus A. Kiemeney, Emil V. R. Appel, Niels Grarup, Diana van Heemst, Youri Taes, Robin P. Peeters, Henry Völzke, Cristian Pattaro, Daniel Medenwald, John M. Starr, Qiong Yang, Jerome I. Rotter, M. Arfan Ikram, Edoardo Fiorillo, Till Ittermann, Oluf Pedersen, Eero Kajantie, John Beilby, Tessel E. Galesloot, Fernando Rivadeneira, Paul Redmond, Bruno Lapauw
Publikováno v:
Nature communications, vol. 9, no. 1, pp. 4455
Nature Communications, 9(1):4455. Nature Publishing Group
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Teumer, A, Chaker, L, Groeneweg, S, Li, Y, Di Munno, C, Barbieri, C, Ahluwalia, T S, Astrup, A, Linneberg, A, Pedersen, O B, Sørensen, T I A & ThyroidOmics Consortium 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, 4455 . https://doi.org/10.1038/s41467-018-06356-1
Nat. Commun. 9:4455 (2018)
Lifelines Cohort Study 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, no. 1, 4455 . https://doi.org/10.1038/s41467-018-06356-1
Nat Commun
Nature Communications, 9:4455. Nature Publishing Group
Teumer, A, Chaker, L, Groeneweg, S, Li, Y, Di Munno, C, Barbieri, C, Schultheiss, U T, Traglia, M, Ahluwalia, T S, Akiyama, M, Appel, E V R, Arking, D E, Arnold, A, Astrup, A, Beekman, M, Beilby, J P, Bekaert, S, Boerwinkle, E, Brown, S J, De Buyzere, M, Campbell, P J, Ceresini, G, Cerqueira, C, Cucca, F, Deary, I J, Deelen, J, Eckardt, K-U, Ekici, A B, Eriksson, J G, Ferrrucci, L, Fiers, T, Fiorillo, E, Ford, I, Fox, C S, Fuchsberger, C, Galesloot, T E, Gieger, C, Gögele, M, De Grandi, A, Grarup, N, Greiser, K H, Haljas, K, Hansen, T, Harris, S E, van Heemst, D, den Heijer, M, Hicks, A A, Liewald, D C M, Redmond, P, Starr, J M, Stott, D J, Taes, Y E, Taliun, D, Toshiko, T, Thuesen, B, Tiller, D, Toniolo, D, Uitterlinden, A G, Visser, W E, Walsh, J P, Wilson, S G, Wolffenbuttel, B H R, Yang, Q, Zheng, H-F, Cappola, A R, Peeters, R P, Naitza, S, Völzke, H, Sanna, S, Köttgen, A, Visser, T J & Medici, M 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, no. 1, pp. 1-14 . https://doi.org/10.1038/s41467-018-06356-1
NATURE COMMUNICATIONS
Nature Communications, 9(1):4455. Nature Publishing Group
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Teumer, A, Chaker, L, Groeneweg, S, Li, Y, Di Munno, C, Barbieri, C, Ahluwalia, T S, Astrup, A, Linneberg, A, Pedersen, O B, Sørensen, T I A & ThyroidOmics Consortium 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, 4455 . https://doi.org/10.1038/s41467-018-06356-1
Nat. Commun. 9:4455 (2018)
Lifelines Cohort Study 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, no. 1, 4455 . https://doi.org/10.1038/s41467-018-06356-1
Nat Commun
Nature Communications, 9:4455. Nature Publishing Group
Teumer, A, Chaker, L, Groeneweg, S, Li, Y, Di Munno, C, Barbieri, C, Schultheiss, U T, Traglia, M, Ahluwalia, T S, Akiyama, M, Appel, E V R, Arking, D E, Arnold, A, Astrup, A, Beekman, M, Beilby, J P, Bekaert, S, Boerwinkle, E, Brown, S J, De Buyzere, M, Campbell, P J, Ceresini, G, Cerqueira, C, Cucca, F, Deary, I J, Deelen, J, Eckardt, K-U, Ekici, A B, Eriksson, J G, Ferrrucci, L, Fiers, T, Fiorillo, E, Ford, I, Fox, C S, Fuchsberger, C, Galesloot, T E, Gieger, C, Gögele, M, De Grandi, A, Grarup, N, Greiser, K H, Haljas, K, Hansen, T, Harris, S E, van Heemst, D, den Heijer, M, Hicks, A A, Liewald, D C M, Redmond, P, Starr, J M, Stott, D J, Taes, Y E, Taliun, D, Toshiko, T, Thuesen, B, Tiller, D, Toniolo, D, Uitterlinden, A G, Visser, W E, Walsh, J P, Wilson, S G, Wolffenbuttel, B H R, Yang, Q, Zheng, H-F, Cappola, A R, Peeters, R P, Naitza, S, Völzke, H, Sanna, S, Köttgen, A, Visser, T J & Medici, M 2018, ' Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation ', Nature Communications, vol. 9, no. 1, pp. 1-14 . https://doi.org/10.1038/s41467-018-06356-1
NATURE COMMUNICATIONS
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, incl
Autor:
Stefan Goemaere, Alain Verstraete, Greet Roef, Kaatje Toye, Jean-Marc Kaufman, Tom Fiers, Youri Taes
Publikováno v:
European Journal of Endocrinology. 169:835-844
ObjectiveVariation in thyroid hormone (TH) concentrations between subjects is greater than in a single subject over a prolonged period of time, suggesting an individual set point for thyroid function. We have previously shown that TH levels within no
Autor:
Gunter Heylens, Katrien Wierckx, Guy T'Sjoen, Sven C. Mueller, Greet Roef, Steven Weyers, Eva Van Caenegem
Publikováno v:
The Journal of Sexual Medicine. 9:2641-2651
Introduction Long‐term effects and side effects of cross‐sex hormone treatment in transsexual persons are not well known. Aim The aim of this study is to describe the effects and side effects of cross‐sex hormone therapy in both transsexual men
Autor:
Kim Brixen, Torben Leo Nielsen, Erik Fransen, Elke Piters, Wim Van Hul, Eveline Boudin, Greet Roef, Marianne Andersen, Youri Taes
Publikováno v:
Molecular genetics and metabolism
Boudin, E, Piters, E, Fransen, E, Nielsen, T L, Andersen, M, Roef, G, Taes, Y, Brixen, K & Van Hul, W 2012, ' Association study of common variants in the sFRP1 gene region and parameters of bone strength and body composition in two independent healthy Caucasian male cohorts ', Molecular Genetics and Metabolism, vol. 106, no. 3, pp. 508-515 . https://doi.org/10.1016/j.ymgme.2011.11.189
Boudin, E, Piters, E, Fransen, E, Nielsen, T L, Andersen, M, Roef, G, Taes, Y, Brixen, K & Van Hul, W 2012, ' Association study of common variants in the sFRP1 gene region and parameters of bone strength and body composition in two independent healthy Caucasian male cohorts ', Molecular Genetics and Metabolism, vol. 106, no. 3, pp. 508-515 . https://doi.org/10.1016/j.ymgme.2011.11.189
Bone mineral density (BMD) and bone strength are predictive parameters for the development of osteoporosis and related fracture later in life. Although it is well known that BMD and bone strength have a high heritability, not much of the variation is
Autor:
Griet Vanbillemont, Jean-Marc Kaufman, Bruno Lapauw, Greet Roef, Hélène De Naeyer, Youri Taes
Publikováno v:
Clinical Endocrinology. 76:111-118
OBJECTIVES:Sex hormone-binding globulin (SHBG) modulates the bioavailability of sex steroids at tissue level. Genetic, hormonal and lifestyle-related factors determine the SHBG levels, and low SHBG levels are a known risk factor for the development o
Autor:
Stefan Goemaere, Hans-Georg Zmierczak, Youri Taes, Tom Fiers, Jean-Marc Kaufman, Bruno Lapauw, Greet Roef
Publikováno v:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
ContextThe hormonal factors involved in the regulation of peak bone mass (PBM) in men have not been fully investigated. Apart from gonadal steroids and somatotropic hormones, thyroid hormones are known to affect bone maturation and homeostasis and ar
Autor:
Michela Traglia, Tom Forsén, Stefano Mariotti, Giorgio Pistis, Katharina Schramm, Jayne A. Franklyn, Suzanne J. Brown, Jürgen Kratzsch, Christian Gieger, W. Edward Visser, Matteo Vocale, Fred C.G.J. Sweep, Daniel Tiller, Anne R. Cappola, Massimiliano Cocca, Johannes W. A. Smit, Johan G. Eriksson, Peter O'Leary, Diana Pietzner, Lise Lotte N. Husemoen, Silvia Naitza, Peter J. Leedman, Alexander Hamilton, Hans J. Grabe, Ee Mun Lim, Jennie Hui, Beverley M. Shields, Allan Linneberg, Richard A. Jensen, Tim De Meyer, Stephen C. L. Gough, Layal Chaker, Henriette E. Meyer zu Schwabedissen, Matthew J. Simmonds, Alice M. Arnold, Marco Medici, Alexandra Bremner, Monia Lobina, Linda Broer, Theo S. Plantinga, Huiling He, Ad R. M. M. Hermus, Eero Kajantie, Daniela Toniolo, Rebecca Nagy, Sita H. Vermeulen, Eva Reischl, Romana T. Netea-Maier, John Beilby, Tessel E. Galesloot, Tim I M Korevaar, Fernando Rivadeneira, Henri Wallaschofski, Peter Feddema, Margit Heier, Uwe Völker, David Schlessinger, J. Brent Richards, Christa Meisinger, Gonçalo R. Abecasis, Rachel M. Freathy, Alessandro P Delitala, Theo J. Visser, Georg Homuth, Corrado Masciullo, Aarno Palotie, Timothy M. Frayling, Elisabeth Widen, Matthias Nauck, Till Ittermann, Betina H. Thuesen, Christin Spielhagen, Jari Lahti, W. G. Li, Nicola Pirastu, Tanguy Corre, Alan James, Lambertus A. Kiemeney, Cinzia Sala, Sandya Liyanarachchi, Bijay Vaidya, Jerome I. Rotter, Jean-Marc Kaufman, Rajesh Rawal, Albert Hofman, Alexander Teumer, Ernst E. Rietzschel, Robin P. Peeters, Henry Völzke, Serena Sanna, John P. Walsh, Greet Roef, Holger Prokisch, Albert de la Chapelle, Stephen J. Fletcher, Alexander Kluttig, Tim D. Spector, André G. Uitterlinden, Martin den Heijer, Alec H. Ross, Eric Wichmann, Katri Räikkönen, Yurii S. Aulchenko, Antonella Mulas, Martijn van de Bunt, David I. W. Philips, Gabriela L. Surdulescu, Andrew T. Hattersley, Dörte Radke, Scott Wilson, Maria Grazia Plia, Y. Taes, Torben Jørgensen, Nicole Soranzo, Bruce M. Psaty, Sandra Lai, Eleonora Porcu, Emanuele Bosi
Publikováno v:
PLOS GENETICS
Plos Genetics, 10, e1004123
Plos Genetics, 10, 2, pp. e1004123
PLoS Genetics, Vol 10, Iss 2, p e1004123 (2014)
PLoS Genetics, 10(2):e1004123. Public Library of Science
PLoS Genetics (print), 10(2). Public Library of Science
PLoS Genetics; Vol 10
PLoS Genetics, 10(2)
Medici, M, Porcu, E, Pistis, G, Teumer, A, Brown, S J, Jensen, R A, Rawal, R, Roef, G L, Plantinga, T S, Vermeulen, S H, Lahti, J, Simmonds, M J, Husemoen, L L N, Freathy, R M, Shields, B M, Pietzner, D, Nagy, R, Broer, L, Chaker, L, Korevaar, T I M, Plia, M G, Sala, C, Volker, U, Richards, J B, Sweep, F C, Gieger, C, Corre, T, Kajantie, E, Thuesen, B, Taes, Y E, Visser, W E, Hattersley, A T, Kratzsch, J, Hamilton, A, Li, W, Homuth, G, Lobina, M, Mariotti, S, Soranzo, N, Cocca, M, Nauck, M, Spielhagen, C, Ross, A, Arnold, A, van de Bunt, M, Liyanarachchi, S, Heier, M, Grabe, H J, Masciullo, C, Galesloot, T E, Lim, E M, Reischl, E, Leedman, P J, Lai, S, Delitala, A, Bremner, A P, Philips, D I W, Beilby, J P, Mulas, A, Vocale, M, Abecasis, G, Forsen, T, James, A, Widen, E, Hui, J, Prokisch, H, Rietzschel, E E, Palotie, A, Feddema, P, Fletcher, S J, Schramm, K, Rotter, J I, Kluttig, A, Radke, D, Traglia, M, Surdulescu, G L, He, H L, Franklyn, J A, Tiller, D, Vaidya, B, Meyer, T, Jorgensen, T, Eriksson, J G, O'Leary, P C, Wichmann, E, Hermus, A R, Psaty, B M, Ittermann, T, Hofman, A, Bosi, E, Schlessinger, D, Wallaschofski, H, Pirastu, N, Aulchenko, Y S, de la Chapelle, A, Netea-Maier, R T, Gough, S C L, Meyer zu Schwabedissen, H, Frayling, T M, den Heijer, M, Naitza, S & Peeters, R P 2014, ' Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease ', PLoS Genetics, vol. 10, no. 2, e1004123 . https://doi.org/10.1371/journal.pgen.1004123
PLoS Genetics
Plos Genetics, 10, e1004123
Plos Genetics, 10, 2, pp. e1004123
PLoS Genetics, Vol 10, Iss 2, p e1004123 (2014)
PLoS Genetics, 10(2):e1004123. Public Library of Science
PLoS Genetics (print), 10(2). Public Library of Science
PLoS Genetics; Vol 10
PLoS Genetics, 10(2)
Medici, M, Porcu, E, Pistis, G, Teumer, A, Brown, S J, Jensen, R A, Rawal, R, Roef, G L, Plantinga, T S, Vermeulen, S H, Lahti, J, Simmonds, M J, Husemoen, L L N, Freathy, R M, Shields, B M, Pietzner, D, Nagy, R, Broer, L, Chaker, L, Korevaar, T I M, Plia, M G, Sala, C, Volker, U, Richards, J B, Sweep, F C, Gieger, C, Corre, T, Kajantie, E, Thuesen, B, Taes, Y E, Visser, W E, Hattersley, A T, Kratzsch, J, Hamilton, A, Li, W, Homuth, G, Lobina, M, Mariotti, S, Soranzo, N, Cocca, M, Nauck, M, Spielhagen, C, Ross, A, Arnold, A, van de Bunt, M, Liyanarachchi, S, Heier, M, Grabe, H J, Masciullo, C, Galesloot, T E, Lim, E M, Reischl, E, Leedman, P J, Lai, S, Delitala, A, Bremner, A P, Philips, D I W, Beilby, J P, Mulas, A, Vocale, M, Abecasis, G, Forsen, T, James, A, Widen, E, Hui, J, Prokisch, H, Rietzschel, E E, Palotie, A, Feddema, P, Fletcher, S J, Schramm, K, Rotter, J I, Kluttig, A, Radke, D, Traglia, M, Surdulescu, G L, He, H L, Franklyn, J A, Tiller, D, Vaidya, B, Meyer, T, Jorgensen, T, Eriksson, J G, O'Leary, P C, Wichmann, E, Hermus, A R, Psaty, B M, Ittermann, T, Hofman, A, Bosi, E, Schlessinger, D, Wallaschofski, H, Pirastu, N, Aulchenko, Y S, de la Chapelle, A, Netea-Maier, R T, Gough, S C L, Meyer zu Schwabedissen, H, Frayling, T M, den Heijer, M, Naitza, S & Peeters, R P 2014, ' Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease ', PLoS Genetics, vol. 10, no. 2, e1004123 . https://doi.org/10.1371/journal.pgen.1004123
PLoS Genetics
Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed03ed08739de03e1de0b148e0bc80c
https://hdl.handle.net/11368/2788327
https://hdl.handle.net/11368/2788327