Výsledky vyhledávání - "Greet G. O. Pattyn"

Chemoradiation interactions under reduced oxygen conditions: Cellular characteristics of an in vitro model

Autor: Sylvia Dewilde, Jan B. Vermorken, Johan Ides, Paul Meijnders, An Wouters, Greet G. O. Pattyn, Filip Lardon, Bea Pauwels, Hilde A. J. Lambrechts, Marc Baay

Publikováno v: Cancer letters

Hypoxic tumour regions often contain viable cells that are more resistant to chemotherapy and/or radiotherapy, making it of key importance to analyse new combination treatments under both normoxic and hypoxic conditions. In this study, the impact of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b145f6f9615ddc68ecd63adfdbee73
https://doi.org/10.1016/j.canlet.2009.05.026

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The role of apoptotic cell death in the radiosensitising effect of gemcitabine

Autor: Greet G. O. Pattyn, Jan B. Vermorken, Bea Pauwels, S. Van Laere, An Wouters, Paul Meijnders, Johan Ides, Filip Lardon, Hilde A. J. Lambrechts, Katrien Vermeulen

Publikováno v: British Journal of Cancer
The British journal of cancer

Background: The aim of this study was to evaluate the radiosensitising effect of gemcitabine, in terms of cell-cycle progression, induction of apoptosis, and to investigate the molecular events regulating apoptosis. Methods: Tumour cells were treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b929c0570bc1a7633f8c017d316a06d
https://doi.org/10.1038/sj.bjc.6605145

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Further mechanistic unravelling of the influence of the cell cycle effects on the radiosensitising mechanism of vinflunine, in vitro

Autor: Filip Lardon, Bea Pauwels, Cindy Simoens, Fabienne Breillout, Greet G. O. Pattyn, Jan B. Vermorken, Hilde A. J. Lambrechts

Publikováno v: Cancer chemotherapy and pharmacology

Vinflunine is an innovative microtubule inhibitor belonging to the vinca alkaloid class that possesses radiosensitising properties, which could lead to promising activity in chemoradiation studies in the clinic. In the current study, different incuba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f16917416287d65cb363e6ec328d3c
https://doi.org/10.1007/s00280-007-0587-4

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The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro

Autor: Hilde A. J. Lambrechts, Christel De Pooter, Filip Lardon, Annelies E. C. Korst, Jan B. Vermorken, Greet G. O. Pattyn, Bea Pauwels

Publikováno v: Cancer chemotherapy and pharmacology

Purpose: Gemcitabine is an active antitumour agent with radiosensitising properties. Gemcitabine is rapidly metabolised, intracellularly as well as extracellularly, by deoxycytidine deaminase to difluorodeoxyuridine (dFdU), a compound with little ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60ea8d4feaf30928c4870213a753fd7
https://doi.org/10.1007/s00280-005-0158-5

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Combined Pap and HPV testing in primary screening for cervical abnormalities: Should HPV detection be delayed until age 35?

Autor: Joost Weyler, Jan B. Vermorken, Wiebren A.A. Tjalma, Filip Lardon, Greet G. O. Pattyn, Marc Baay, Eric Van Marck, Paul Van Royen, Hilde A. J. Lambrechts

Publikováno v: European journal of cancer
ResearcherID

In 2003, the United States Food and Drug Administration has approved the Hybrid Capture 2 assay for use with a Pap test to adjunctively screen women of 30 years and older for the presence of high-risk human papillomavirus (HR-HPV) infection. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306bbe8574d48593fdc5ca1691fa0a9f
https://doi.org/10.1016/j.ejca.2005.04.050

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In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells

Autor: Greet G. O. Pattyn, Bea Pauwels, Hilde A. J. Lambrechts, Paul Meijnders, Filip Lardon, Marc Baay, Jan B. Vermorken, An Wouters

Publikováno v: BMC cancer
BMC Cancer, Vol 10, Iss 1, p 441 (2010)
BMC Cancer

Background Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248a4b989ccde912fca80fb0fa83f1de
https://doi.org/10.1186/1471-2407-10-441

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Counting clonogenic assays from normoxic and anoxic irradiation experiments manually or by using densitometric software

Autor: Johan Ides, Paul Meijnders, Greet G. O. Pattyn, An Wouters, Jan B. Vermorken, Bea Pauwels, Marc Baay, Hilde A. J. Lambrechts, Filip Lardon

Publikováno v: Physics in medicine & biology

The clonogenic assay is the method of choice to determine cell reproductive death after in vitro irradiation treatment. Traditionally, colony quantification has been performed by manual counting, a very laborious, time-consuming and rather subjective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5889fa45374507e00a2e7451929f224e
https://hdl.handle.net/10067/809480151162165141

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Feasibility of collecting self-sampled vaginal swabs by mail: quantity and quality of genomic DNA

Autor: P. Van Royen, Veronique Verhoeven, Filip Lardon, Hilde A. J. Lambrechts, Greet G. O. Pattyn, Marc Baay, Jan B. Vermorken

Publikováno v: European journal of clinical microbiology and infectious diseases

Vaginal self-sampling may be valuable as an alternative method of cervical cancer screening in areas of poor resources, to enrol women who, otherwise, would not participate in population-based cervical cancer screening and in epidemiological follow-u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebed3e60c80654227a304f641454972
https://hdl.handle.net/10067/774580151162165141

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Comparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, **in vitro**

Autor: Greet G. O. Pattyn, Filip Lardon, Cindy Simoens, Hilde A. J. Lambrechts, Fabienne Breillout, Bea Pauwels, Christel De Pooter, Jan B. Vermorken

Publikováno v: BMC cancer
BMC Cancer, Vol 8, Iss 1, p 65 (2008)
BMC Cancer

Background Vinca alkaloids are an important class of anticancer agents and semisynthetic vinca alkaloids are developed to improve the therapeutic index of this class of drugs. In the present study, a direct comparison was made between vinflunine and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1208d3d027e82af9efacf683d5202354
https://hdl.handle.net/10067/684110151162165141

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Routine Analysis of Fluorouracil in Plasma by High-Performance Liquid Chromatography and Gas Chromatography. A Comparison and Implications for Pharmacokinetic Analysis

Autor: J. A. C. Oltvoort-Van Der Panne, Greet G. O. Pattyn, E. A. De Bruijn, J. M. R. Hollander

Publikováno v: Journal of Liquid Chromatography. 13:1173-1189

A comparison between a high-performance liquid chromatographic (HPLC) and a gas chromatographic (GC) assay for routine determination of 5-f1uarouraci1 (FUra) in plasma is described. Bath assays are based upon a rapid and simple plasma pretreatment wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4ea2e68865170ca374a6e75c843de7a
https://doi.org/10.1080/01483919008049241

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