A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease

Autor: Lawrence Elmer, McGuire D, Janis M. Miyasaki, Pierre N. Tariot, Cynthia L. Comella, Rajesh Pahwa, S. Schuman, Margaret C. Lannon, James W. Tetrud, Wiener W, Christopher Cox, Oksana Suchowersky, Wratni E, Lucia M. Blasucci, Chase T, Greenamyre Jt, Karen Hodgeman, Deleo A, Michael P. McDermott, Carrion A, Panniset M, Paula D. Ryan, Robert A. Hauser, Johnston L, Bateman-Rodriguez D, Amy Colcher, Baker D, Mistura K, Andrew Siderowf, W.R. Wayne Martin, Peggy Gray, Constance Orme, Jeffrey Friedlander, Charles H. Adler, Dilllon S, Stanley Fahn, Eric Siemers, David Grimes, Lauren Seeberger, M. Brewer, Colleen Dingmann, Frey J, Holdich T, Cooper J, Mark Stacy, Stewart A. Factor, Daniel Tarsy, Kennedy L, McCree L, Mary Lloyd, J. B. Penney, Lisa Gauger, Pantella C, Arthur Watts, Kenneth Marek, John P. Hammerstad, Matthews M, Kimberly Janko, Diane Brown, Denni Day, McDermott J, Sulimowicz K, Ruzicka D, Marsha Tennis, Bardram K, Joann Belden, Madaline B. Harrison, Blair Ford, Davies R, Mark F. Lew, Alderfer, Jennifer Mazurkiewicz, Elise Kayson, Broshjeit S, Rexo L, Andrew Feigin, Craun Am, Cha Jh, C. Stone, Stephanie Newman, Nirupama Laroia, Jean Hall, Ira Shoulson, Peter A LeWitt, Read B, Robert L. Rodnitzky, Danna Jennings, Judith Dobson, Lang A, Florack M, Nobel R, Steven R. Schwid, Leventhal C, A. L. Lafontaine, Nancy Pearson, Lawrence N. Shulman, Rothenburgh K, Rost E, Locke B, Cindy Casaceli

Publikováno v: Neurology. 56:455-462

Background Preclinical studies suggest that glutamate antagonists help ameliorate motor fluctuations in patients with PD treated with levodopa. Methods In a multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d568a8ad50ad99173f553a65cfb0dde5
https://doi.org/10.1212/wnl.56.4.455

Bioenergetics and glutamate excitotoxicity

Autor: Greenamyre Jt, Greene Jg

Publikováno v: Progress in Neurobiology. 48:613-634

Bioenergetic defects and abnormalities in glutamate neurotransmission have both been proposed to play important roles in neurological diseases of varying chronology, etiology and pathology. Recent experimental evidence suggests an intimate relationsh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bed4c273cac8eb2a2e06e09f837855
https://doi.org/10.1016/0301-0082(96)00006-8

Blockade of subthalamic glutamatergic activity corrects changes in neuronal metabolism and motor behavior in rats with nigrostriatal lesions

Autor: G. Nappi, Fabio Blandini, R. Fancellu, Greenamyre Jt

Publikováno v: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 22(1)

We infused – for four weeks – a selective antagonist of the NMDA receptor, MK-801, into the subthalamic nucleus of rats bearing an evolving nigrostriatal lesion. The aim was to block the subthalamic overactivity resulting from the dopaminergic st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd9824cbf7d455ed196b79b95965cdd
https://pubmed.ncbi.nlm.nih.gov/11487196

Chronic treatment with thioctic acid does not protect against malonate toxicity in vivo

Autor: Angel R, Greenamyre Jt

Publikováno v: Neuroscience letters. 196(1-2)

We reported previously that short-term systemic pretreatment with thioctic acid is protective against NMDA and malonate lesions of the striatum. In the current study, we examined the effects of 3 weeks of pretreatment with various doses of thioctic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930127df7fa67d727359e632e34f61e4
https://pubmed.ncbi.nlm.nih.gov/7501239

Quantitative autoradiography of dihydrorotenone binding to complex I of the electron transport chain

Autor: Eller Rv, Donald S. Higgins, Greenamyre Jt

Publikováno v: Journal of neurochemistry. 59(2)

Defective complex I activity has been linked to Parkinson's disease and Huntington's disease, but little is known of the regional distribution of this enzyme in the brain. We have developed a quantitative autoradiographic assay using [3H]dihydroroten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0dcd206e8c49a1605de642a9cb75c1
https://pubmed.ncbi.nlm.nih.gov/1629744