Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Grebinski, James W."'
Autor:
Hart Amy C, Javed Khan, Grebinski James W, James Kempson, Jonathan Lippy, Gretchen M. Schroeder, Theresa M. McDevitt, Ashok V. Purandare, Ragini Vuppugalla, John S. Tokarski, George L. Trainor, Junqing Guo, Jennifer Inghrim, Matthew V. Lorenzi, Dan You, Honghe Wan, John S. Sack, William J. Pitts, Yueping Zhang, Louis J. Lombardo
Publikováno v:
ACS Medicinal Chemistry Letters. 6:845-849
Early hit to lead work on a pyrrolopyridine chemotype provided access to compounds with biochemical and cellular potency against Janus kinase 2 (JAK2). Structure-based drug design along the extended hinge region of JAK2 led to the identification of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012e89c2b8ac320dc2991a1451732264
https://doi.org/10.1021/acsmedchemlett.5b00225
https://doi.org/10.1021/acsmedchemlett.5b00225
Autor:
Ayalew Tefferi, Theresa M. McDevitt, Ashok V. Purandare, Stuart Emanuel, Becky Penhallow, Grebinski James W, George L. Trainor, Marco M. Gottardis, Francis Y. Lee, Jennifer Hosbach, Honghe Wan, Animesh Pardanani, Terra L. Lasho, Stefan Ruepp, Dan You, John S. Tokarski, Gretchen M. Schroeder, Jennifer Inghrim, Hart Amy C, Louis J. Lombardo, Yueping Zhang, Matthew V. Lorenzi, Ragini Vuppugalla, Xia Han, Elizabeth Fitzpatrick
Publikováno v:
Cancer Research. 71:DDT01-03
Myeloproliferative diseases (MPDs) are a subset of myeloid malignancies that are characterized by the expansion of a multipotent hematopoietic stem cell. Chronic MPDs can be classified into two categories, those harboring the BCR-ABL oncogene and tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c627273340d9262ad04f607368721c3c
https://doi.org/10.1158/1538-7445.am2011-ddt01-03
https://doi.org/10.1158/1538-7445.am2011-ddt01-03
Autor:
Perez, Heidi L., Banfi, Patrizia, Bertrand, Jay, Cai, Zhen-Wei, Grebinski, James W., Kim, Kyoung, Lippy, Jonathan, Modugno, Michele, Naglich, Joseph, Schmidt, Robert J., Tebben, Andrew, Vianello, Paola, Wei, Donna D., Zhang, Liping, Galvani, Arturo, Lombardo, Louis J., Borzilleri, Robert M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 June 2012 22(12):3946-3950
Autor:
Grebinski James W, Arturo Galvani, Jonathan Lippy, Michele Modugno, Andrew J. Tebben, Robert M. Borzilleri, Jay Bertrand, Robert J. Schmidt, Donna D. Wei, Liping Zhang, Zhen Wei Cai, Louis J. Lombardo, Patrizia Banfi, Heidi L. Perez, Joseph G. Naglich, Kyoung S. Kim, Paola Vianello
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(12)
A series of phenylacylsulfonamides has been prepared as antagonists of Bcl-2/Bcl-xL. In addition to potent binding affinities for both Bcl-2 and Bcl-xL, these compounds were shown to induce classical markers of apoptosis in isolated mitochondria. Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2e9c1416ad9c8fc50b20dfecfec7b0
https://pubmed.ncbi.nlm.nih.gov/22608961
https://pubmed.ncbi.nlm.nih.gov/22608961
Publikováno v:
Proceedings of SPIE; Nov2004, Issue 1, p116-127, 12p
Publikováno v:
MRS Online Proceedings Library; 2004, Vol. 848 Issue 1, p394-399, 6p
Akademický článek
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Autor:
Khandelwal, Anubhav, Jena, Debdeep, Grebinski, James W., Hull, Katherine Leigh, Kuno, Masaru K.
Publikováno v:
Journal of Electronic Materials; Jan2006, Vol. 35 Issue 1, p170-172, 3p, 3 Graphs
Akademický článek
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Publikováno v:
ChemInform; Aug2008, Vol. 39 Issue 33, pno-no, 1p