Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Grégory Menchon"'
Autor:
Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 755-764 (2019)
Externí odkaz:
https://doaj.org/article/25fe86c26b2f41b2afb5b7ee20b13b6c
Autor:
Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J. Fernando Díaz, Karl-Heinz Altmann, Michel O. Steinmetz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identi
Externí odkaz:
https://doaj.org/article/0ff5964567e04f11ab1504ca1c9d29cf
Autor:
Andrea E. Prota, Wolfgang Dohle, Barry V. L. Potter, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 755-764 (2019)
ACS Omega
ACS Omega
Tetrahydroisoquinoline (THIQ) 6-O-sulfamate-based anticancer agents, inspired by the endogenous steroid 2-methoxyestradiol and its sulfamate derivatives, are further explored for antiproliferative and microtubule disruptor activity. Based on recently
Autor:
Ernest Hamel, Pascoe Mannion, Grégory Menchon, Mathew P. Leese, Michel O. Steinmetz, Philip G. Kasprzyk, Mark P. Thomas, Eric Ferrandis, Barry V. L. Potter, Fabrice Jourdan, Paul A. Foster, Andrea E. Prota, Wolfgang Dohle
Publikováno v:
Journal of Medicinal Chemistry. 61:1031-1044
Quinazolinone-based anti-cancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors. The steroidal AB-ring s
Autor:
Grégory Menchon, Lucia Altucci, Giulia Chemi, Simone Brogi, Michel O. Steinmetz, Angela Nebbioso, Natacha Olieric, Daniela M. Zisterer, Francisco de Asís Balaguer, Stefania Butini, Rebecca Amet, Cristina Ulivieri, Alessandro Grillo, Jeff O'Sullivan, Isabel Barasoain, Margherita Brindisi, J. Fernando Díaz, Ettore Novellino, Roberta Spaccapelo, Daniel Lucena-Agell, Ludovica Lopresti, Andrea E. Prota, Sandra Gemma, Mariarosaria Conte, Stefania Magnano, Cosima T. Baldari, Gloria Alfano, Giuseppe Campiani, Paula Kinsella, Tuhina Khan, Lucia Morbidelli, Ola Ibrahim
Publikováno v:
European Journal of Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. Benzoxazepines were recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac07af3e053396026a7fa9fca0f7aa6
http://hdl.handle.net/11391/1447652
http://hdl.handle.net/11391/1447652
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1762
Rational drug design is essential for new drugs to emerge, especially when the structure of a target protein or catalytic enzyme is known experimentally. To that purpose, high-throughput virtual ligand screening campaigns aim at discovering computati
Autor:
Rolf Müller, Pascal Bucher, Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, J. Fernando Díaz, Ian Paterson, Michel O. Steinmetz, Herbert Irschik, Rolf Jansen, Karl-Heinz Altmann
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, 9 (1)
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, 9 (1)
9 p.-5 fig.-1 tab. Menchon, Gregory et al.
Microtubule-targeting agents (MTAs) like taxol and vinblastine are among the most successful chemotherapeutic drugs against cancer. Here, we describe a fluorescence anisotropy-based assay that specifica
Microtubule-targeting agents (MTAs) like taxol and vinblastine are among the most successful chemotherapeutic drugs against cancer. Here, we describe a fluorescence anisotropy-based assay that specifica
Publikováno v:
Methods in Molecular Biology ISBN: 9781493977550
Rational drug design is essential for new drugs to emerge, especially when the structure of a target protein or catalytic enzyme is known experimentally. To that purpose, high-throughput virtual ligand screening campaigns aim at discovering computati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152fa170856d0bca21a418fbef32e736
https://doi.org/10.1007/978-1-4939-7756-7_9
https://doi.org/10.1007/978-1-4939-7756-7_9
Autor:
Michel Jordi, John H. Miller, J. Fernando Díaz, Benet Pera, Grégory Menchon, Juan Estévez Gallego, José Manuel Andreu, Javier Rodríguez-Salarichs, Didier Zuwerra, Andrea E. Prota, Enrique Calvo, Gonzalo Sáez-Calvo, Jessica J. Field, Karl-Heinz Altmann
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
41 p.-8 fig.-2 tab. Field, Jessica J. et al.
The marine natural product zampanolide and analogues thereof constitute a new chemotype of taxoid site microtubule-stabilizing agents with a covalent mechanism of action. Zampanolide-ligated tubulin h
The marine natural product zampanolide and analogues thereof constitute a new chemotype of taxoid site microtubule-stabilizing agents with a covalent mechanism of action. Zampanolide-ligated tubulin h
Autor:
Oriane Bombarde, Cyril Inard, Alain Milon, Grégory Menchon, Patrick Calsou, Georges Czaplicki, Aurélie Négrel, Michel Baltas, Brigitte Giudetti, Mansi Trivedi, Mauro Modesti
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, pp.22878. ⟨10.1038/srep22878⟩
Scientific Reports, 2015, 6, pp.22878. ⟨10.1038/srep22878⟩
Scientific Reports, Nature Publishing Group, 2015, pp.22878. ⟨10.1038/srep22878⟩
Scientific Reports, 2015, 6, pp.22878. ⟨10.1038/srep22878⟩
The association of DNA Ligase IV (Lig4) with XRCC4 is essential for repair of DNA double-strand breaks (DSBs) by Non-homologous end-joining (NHEJ) in humans. DSBs cytotoxicity is largely exploited in anticancer therapy. Thus, NHEJ is an attractive ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b270cf96133b0db49d5b80fbf6a8b7a
https://hal-amu.archives-ouvertes.fr/hal-01456277/document
https://hal-amu.archives-ouvertes.fr/hal-01456277/document