Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Grazyna Sobal"'
Autor:
Maximilian Pagitz, Siegfried Kosik, Grazyna Sobal, Johannes Menzel, Marcus Hacker, Kavitha Velusamy
Publikováno v:
Nuclear Medicine and Biology. 43:339-346
Purpose In previous in-vitro and ex-vivo studies we proved the specific uptake of 99mTc radiolabeled chondroitin sulfate (CS) in human articular cartilage. As a logical next step for the clinical use for imaging osteoarthritis we investigated in-vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a725ba58a3ba0a5395b9f178f25246
https://doi.org/10.1016/j.nucmedbio.2016.02.009
https://doi.org/10.1016/j.nucmedbio.2016.02.009
Publikováno v:
Chemistry and Physics of Lipids. 164:563-572
In the present study a direct detection approach combining size-exclusion chromatography (SEC) and matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight tandem-mass spectrometry (MALDI-QIT-TOF-MS/MS) was applied to investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dd08b85d86b38386f09ffc23ed07eb
https://doi.org/10.1016/j.chemphyslip.2011.06.002
https://doi.org/10.1016/j.chemphyslip.2011.06.002
Publikováno v:
Nuclear Medicine and Biology. 36:65-71
Chondroitin sulfate (CS) is used in the treatment of human osteoarthritis as a slow-acting symptomatic drug. For this reason, we performed uptake studies with (99m)TcCS using different chondrocyte cultures, as well as cartilage tissue in vitro. For u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9b1db252221108e194e3bf78513c64
https://doi.org/10.1016/j.nucmedbio.2008.10.013
https://doi.org/10.1016/j.nucmedbio.2008.10.013
Publikováno v:
Journal of Receptors and Signal Transduction. 26:693-707
Native (n), glycated (g), and glycoxidated (go) low-density lipoproteins (LDL) were labeled with 125I or 99mTc, and the labeling efficiency and binding were assessed for potential use of these LDL compounds in imaging analysis of atherosclerotic lesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a6b908531197e8e35bc0b0c918b3d0
https://doi.org/10.1080/10799890600939472
https://doi.org/10.1080/10799890600939472
Autor:
Helmut Sinzinger, Grazyna Sobal
Publikováno v:
Biochemical Pharmacology. 70:1185-1191
Modified (oxidized) low-density lipoprotein (LDL) plays a significant role in atherosclerosis by accumulation in arteries. Also, glycated LDL, such as in diabetics, are increasing the risk for atherosclerosis, due to an increased oxidizability as com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a040d7a058b057604bfddc30927374
https://doi.org/10.1016/j.bcp.2005.07.022
https://doi.org/10.1016/j.bcp.2005.07.022
Publikováno v:
Biochemical Pharmacology. 61:373-379
1 The peroxidation step in lipid transformation is considered to be essential in the pathogenesis of atherosclerosis. Calcium antagonists (CA) appear to have antioxidant effects in addition to their potent vasorelaxant properties. In the present stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2d3a813010340fba0780d92cbb80c7
https://doi.org/10.1016/s0006-2952(00)00548-7
https://doi.org/10.1016/s0006-2952(00)00548-7
Publikováno v:
Life Sciences. 67:695-707
Troglitazone (T), an anti-diabetic drug improving insulin resistance, was studied as to its inhibition of copper ion-catalysed oxidation of native, glycated and glycoxidated low-density lipoprotein (LDL). A dose-dependent inhibition was noted in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81cb138a35e3eb355c7fcc2afd88231
https://doi.org/10.1016/s0024-3205(00)00662-7
https://doi.org/10.1016/s0024-3205(00)00662-7
Publikováno v:
Life Sciences. 66:1987-1998
It is generally accepted that oxidation of low-density lipoproteins (LDL) is a causal factor in the development of atherosclerosis. Non-enzymatic glycosylation of LDL, i.e."glycation", plays a central role in late complications of diabetes mellitus a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf7358bdd1ef6cf78b7354da5d5a62c
https://doi.org/10.1016/s0024-3205(00)00524-5
https://doi.org/10.1016/s0024-3205(00)00524-5
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 62:217-224
In individuals suffering from diabetes mellitus, low-density lipoprotein (LDL) can undergo glycoxidation, both the surface protein and the unsaturated fatty acids in the particle core experiencing oxidative damage. In these patients, plasma levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1096493bc7ddf38c613313c65b50d9c6
https://doi.org/10.1054/plef.2000.0146
https://doi.org/10.1054/plef.2000.0146
Autor:
Mahmoud Melling, Christa Zangerle, Grazyna Sobal, Wolfgang Pfeiler, Martina Schnallinger, Daniela Karimian-Teherani, Ernst J. Menzel
Publikováno v:
The Anatomical Record. 259:327-333
The aim of this work was to compare biochemical, two-dimensional biomechanical and calorimetric parameters of diabetic skin vs. control skin. Skin specimens taken from the palms and backs of the hands of aged persons with non-insulin-dependent diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d67a1ccfa83fc3bc98847b1c807478
https://doi.org/10.1002/1097-0185(20000701)259:3<327::aid-ar90>3.0.co
https://doi.org/10.1002/1097-0185(20000701)259:3<327::aid-ar90>3.0.co