Phase 2 trial of the DPP-1 inhibitor brensocatib in bronchiectasis

Autor: Chalmers, J. D., Haworth, C. S., Metersky, M. L., Loebinger, M. R., Blasi, F., Sibila, O., O'Donnell, A. E., Sullivan, E. J., Mange, K. C., Fernandez, C., Zou, J., Simon D Bowler, Daley C. L., Michael, Chia, Hugh, Greville, Lucy, C Morgan, Siobhain, Mulrennan, Daniel, J Smith, Francis, Thien, Rachel, Thomson, John, Wilson, Natalie, Lorent, Damyan, Arabadzhiev, Mariya, Dimitrova-Georgieva, Ivan, Kiselov, Christo, Terziev, Karen Elisabeth Martha Bendstrup, Christian, N Meyer, Charlotte, Ulrik, Andres, Deroux, Andreas, Eich, Joachim, Ficker, Wolfgang, Gleiber, Christian, Herzmann, Anneliese, Linnhoff, Pontus, Mertsch, Mathias, Pletz, Sivagurunathan, Sutharsan, Francesco, Blasi, Angelo Guido Corsico, Alberto, Pesci, Celi, Alessandro, Mauro, Maniscalco, G Boersma, W, Michiel de Vries, Monique, Reijers, Simone Van der Sar, Benedict, Brockway, Daniel, Garner, John, Kolbe, Catherina, Chang, Paul, Noonan, Adam, Antczak, Elzbieta, Hajoł, Grazyna, Jasieniak-Pinis, Marcin, Bukowczan, Piotr, Napora, Mariko, Koh, Sung Hwan Jeong, Jusang, Kim, Yu-Ii, Kim, Chang-Hoon, Lee, Sook-Young, Lee, Sang Haak Lee, Jeong-Seon, Ryu, Tae Sun Shim, Kwang-Ha, Yoo, Jordi, Dorca, Oriol, Sibila, Antoni, Torres, Rosario, Menendez, Montserrat, Vendrell, Zoe, Borrill, James, Chalmers, Dilip, Nazareth, Richard, Carter, Charles, Haworth, Monica, Nordstrom, Mary, Carroll, Michael, Loebinger, Tarek, Saba, Pinak, Acharya, Ivan, F Ackerman, Idalia, A Acosta, Doreen, Addrizzo-Harris, Juzar, Ali, Francis, Averill, Linda, Barr, Wissam, Chatila, Daniel, Dorgan, Rodney, Folz, Douglas, Hornick, Shijing, Jia, Ryan, Klein, Jorge, Lascano, Rabih, Loutfi, Peadar, Noone, Pamela, Mcshane, Mark, L Metersky, Brian, Morrissey, Anne, O'Donnell, Robert, Orr, Maria Gabriela Tupayachi Ortiz, Julie, Philley, Stephen, Ruoss, Stephen, Ryan, Salma, Saiger, Barry, Sigal, George, Solomon, Colin, Swenson, Ziad, Tannous, Fred, Umeh, Kevin, L Winthrop

Patients with bronchiectasis have frequent exacerbations that are thought to be related to neutrophilic inflammation. The activity and quantity of neutrophil serine proteases, including neutrophil elastase, are increased in the sputum of patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8725e9fa4f97f8398c93b2d13e97a5f6
http://hdl.handle.net/11568/1071553