Genetic variation of the serotonin 2a receptor affects hippocampal novelty processing in humans.

Autor: Björn H Schott, Constanze I Seidenbecher, Sylvia Richter, Torsten Wüstenberg, Grazyna Debska-Vielhaber, Heike Schubert, Hans-Jochen Heinze, Alan Richardson-Klavehn, Emrah Düzel

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e15984 (2011)

Serotonin (5-hydroxytryptamine, 5-HT) is an important neuromodulator in learning and memory processes. A functional genetic polymorphism of the 5-HT 2a receptor (5-HTR2a His452Tyr), which leads to blunted intracellular signaling, has previously been

Externí odkaz: https://doaj.org/article/fb490b9ec1c243d58c9ce81924360cae

Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

Autor: Philipp Ulbrich, Lorena Morton, Michael Briese, Naomi Lämmlin, Hendrik Mattern, Md. Hasanuzzaman, Melina Westhues, Mahsima Khoshneviszadeh, Silke Appenzeller, Daniel Gündel, Magali Toussaint, Peter Brust, Torsten Kniess, Anja Oelschlegel, Jürgen Goldschmidt, Sven Meuth, Hans-Jochen Heinze, Grazyna Debska-Vielhaber, Stefan Vielhaber, Axel Becker, Alexander Dityatev, Solveig Jandke, Michael Sendtner, Ildiko Dunay, Stefanie Schreiber

Chronic arterial hypertension causes cerebral microvascular dysfunction and doubles dementia risk in aging. However, cognitive health preservation by therapeutic blood pressure lowering alone is limited and depends on disease duration, the degree of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1099a4ecd522621afe81e01e6f9f610
https://doi.org/10.1101/2023.01.20.524921

Novel Pathogenic Sequence Variation m.5789TC Causes NARP Syndrome and Promotes Formation of Deletions of the Mitochondrial Genome

Autor: Marius Hippen, Gábor Zsurka, Viktoriya Peeva, Judith Machts, Kati Schwiecker, Grazyna Debska-Vielhaber, Rudolf J. Wiesner, Stefan Vielhaber, Wolfram S. Kunz

Publikováno v: Neurology. Genetics. 8(2)

Background and ObjectivesWe report the pathogenic sequence variant m.5789T>C in the anticodon stem of the mitochondrial tRNA for cysteine as a novel cause of neuropathy, ataxia, and retinitis pigmentosa (NARP), which is usually associated with pathog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e180d56c9cbaea997f5b49f2334c45ef
https://pubmed.ncbi.nlm.nih.gov/35252560

Toward in vivo determination of peripheral nervous system immune activity in amyotrophic lateral sclerosis

Autor: Cornelia Garz, Grazyna Debska-Vielhaber, Susanne Petri, Stefan Vielhaber, Anne Assmann, Reinhard Dengler, Peter J. Nestor, Valentina Perosa, Stefanie Schreiber, Frank Schreiber

Publikováno v: Muscle & nerve 59(5), 567-576 (2019). doi:10.1002/mus.26444

We sought to identify patients with amyotrophic lateral sclerosis (ALS) who displayed suspected peripheral nervous system (PNS) inflammation to compare them to those with suspected PNS degeneration.We measured sonographic median and ulnar nerve cross

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435f20ade613ae69e68970c4873bbfb7
https://doi.org/10.1002/mus.26444

Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply

Autor: Thomas Endres, Stefan Vielhaber, Kerstin Hallmann, Niki Karavasili, Marten Szibor, Frank Schreiber, T. M. Gainutdinov, Volkmar Lessmann, Michael Schwarzer, Zemfira Gizatullina, Torsten Doenst, Matthias Kunz, Wolfram S. Kunz, Grazyna Debska-Vielhaber, Frank N. Gellerich, Alexandra Bamberger, Hans-Jochen Heinze

Publikováno v: The journal of biological chemistry 295(14), 4383-4397 (2020). doi:10.1074/jbc.RA119.011902
The journal of biological chemistry, 295(14):4383-4397
The Journal of Biological Chemistry

Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3d6448d2f54ea5c8e34997c143a0fa