Increased Phenacetin Oxidation upon the L382V Substitution in Cytochrome P450 1A2 is Associated with Altered Substrate Binding Orientation

Autor: Grazyna D. Szklarz, Qingbiao Huang

Publikováno v: International Journal of Molecular Sciences; Volume 19; Issue 6; Pages: 1580
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1580 (2018)
International Journal of Molecular Sciences

Leucine382 of cytochrome P450 1A2 (CYP1A2) plays an important role in binding and O-dealkylation of phenacetin, with the L382V mutation increasing substrate oxidation (Huang and Szklarz, 2010, Drug Metab. Dispos. 38:1039–1045). This was attributed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8911dbafdb780a09a5a3357e1d7ef2f8

The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Autor: Yongyi Bi, Yon Rojanasakul, Liping Wang, Grazyna D. Szklarz, Xiaoqing He, Qiang Ma

Publikováno v: Archives of Biochemistry and Biophysics. 537:31-38

NAD(P)H:quinoneoxidoreductase 1 (NQO1) belongs to a group of the aryl hydrocarbon receptor (AhR) battery of drug-metabolizing enzymes that are characteristically induced by both AhR agonists and nuclear factor erythroid 2-related factor 2 (Nrf2) acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e929eabca3c0c959ad178d7e26217f
https://doi.org/10.1016/j.abb.2013.06.001

A study of rural upbringing and education on the intent of health professional students to work in rural settings

Autor: Greg A. Barretto, Alcinda K. Trickett-Shockey, Grazyna D. Szklarz, Christina S. Wilson, Gail C. VanVoorhis, Laura R. Lander, Joseph Minardi

Publikováno v: International Journal of Medical Education

Objectives To explore whether student rural upbringing, rural training were associated with their intent to practice in a rural health care setting after graduation in the disciplines of Dentistry, Dental Hygiene, Medicine, Nursing, and Pharmacy at a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ffa599e63a766fa7bc12585796a759
https://doi.org/10.5116/ijme.50f1.48cf

Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid

Autor: Spencer S. Ericksen, Horst Honeck, Dieter Schwarz, Pyotr Kisselev, Wolf-Hagen Schunck, Grazyna D. Szklarz, Alexey Chernogolov, Ivar Roots

Publikováno v: Biochemical Pharmacology. 67:1445-1457

Human cytochrome P450 1A1 (CYP1A1) and human NADPH-cytochrome P450 reductase were expressed and purified from Spodoptera frugiperda insect cells. A reconstituted enzymatically active system metabolized polyunsaturated fatty acids such as arachidonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc66a55428e5d58aea4624e9b95d2f47
https://doi.org/10.1016/j.bcp.2003.12.023

Probing the Active Site of Cytochrome P450 2B1: Metabolism of 7-Alkoxycoumarins by the Wild Type and Five Site-Directed Mutants

Autor: Yasuna Kobayashi, Xiaojun Fang, James R. Halpert, Grazyna D. Szklarz

Publikováno v: Biochemistry. 37:6679-6688

A series of 7-alkoxycoumarins (chain length of 1-7 carbon atoms) was utilized as active site probes of purified Escherichia coli-expressed cytochrome P450 2B1 wild type and five site-directed mutants (I114V, F206L, V363A, V363L, and G478S). The produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e482d708accaa5fd40b5964643d80266
https://doi.org/10.1021/bi9731450