Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas

Autor: Vladimir Amani, Kent A. Riemondy, Rui Fu, Andrea M. Griesinger, Enrique Grimaldo, Graziella Ribeiro De Sousa, Ahmed Gilani, Molly Hemenway, Nicholas K. Foreman, Andrew M. Donson, Nicholas Willard

Publikováno v: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)

Abstract Plexiform neurofibroma (PN) is a leading cause of morbidity in children with the genetic condition Neurofibromatosis Type 1 (NF1), often disfiguring or threatening vital structures. During formation of PN, a complex tumor microenvironment (T

Externí odkaz: https://doaj.org/article/fc4960bbcb234d0f88ab1397fa08f1c5

Significant increase of high-risk chromosome 1q gain and 6q loss at recurrence in posterior fossa group A ependymoma: a multicenter study

Autor: Andrew M Donson, Kelsey C Bertrand, Kent A Riemondy, Dexiang Gao, Yonghua Zhuang, Bridget Sanford, Gregory A Norris, Rebecca J Chapman, Rui Fu, Nicholas Willard, Andrea M Griesinger, Graziella Ribeiro de Sousa, Vladimir Amani, Enrique Grimaldo, Todd C Hankinson, Ffyona Booker, Martin Sill, Richard G Grundy, Kristian W Pajtler, David W Ellison, Nicholas K Foreman, Timothy A Ritzmann

Publikováno v: Neuro-Oncology.

Background Ependymoma (EPN) posterior fossa group A (PFA) has the highest rate of recurrence and the worst prognosis of all EPN molecular groups. At relapse, it is typically incurable even with re-resection and re-irradiation. The biology of recurren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7409daef81b91b86628c6e94df210ae6
https://doi.org/10.1093/neuonc/noad096

Identification of ITPR1 as a Hub Gene of Group 3 Medulloblastoma and Coregulated Genes with Potential Prognostic Values

Autor: Suely Kazue Nagahashi Marie, Pablo Ferreira das Chagas, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Graziella Ribeiro de Sousa, Luis Fernando Peinado Nagano, Luciana Chain Veronez, Andrea Martins-da-Silva, Elvis Terci Valera, Silvia Regina Brandalise, Gustavo Alencastro Veiga Cruzeiro, Carolina Alves Pereira Corrêa, Luiz Gonzaga Tone

Publikováno v: Journal of Molecular Neuroscience. 72:633-641

The Group 3 Medulloblastoma (Grp3-MB) is an aggressive molecular subtype with a high incidence of metastasis and deaths. In this study, were used an RNA sequencing data (RNA-Seq) from a Brazilian cohort of MBs to identify hub genes associated with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e4126d899ba7cec9e736b11344716a1
https://doi.org/10.1007/s12031-021-01942-3

Knockdown of Musashi-1 enhances chemotherapeutic sensitivity and apoptosis in Group 3/4 medulloblastomas cells

Autor: Pablo Shimaoka Chagas, Luciana Chain Veronez, Graziella Ribeiro de Sousa, Gustavo Alencastro Veiga Cruzeiro, Carolina Alves Pereira Corrêa, Fabiano Pinto Saggioro, Rosane Gomes de Paula Queiroz, Suely Kazue Nagahashi Marie, Silvia Regina Brandalise, Izilda Aparecida Cardinalli, José Andres Yunes, Carlos Gilberto Carlotti Júnior, Hélio Rubens Machado, Marcelo Volpon Santos, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Elvis Terci Valera

Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a paucity of biomarkers for these subtypes of MBs. The RNA-binding protein Musashi-1 (MSI1) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1048243a19a6ef07a17d0705eb3c1405
https://doi.org/10.21203/rs.3.rs-1800310/v1

Ultraconserved long non-coding RNA uc.112 is highly expressed in childhood T versus B-cell acute lymphoblastic leukemia

Autor: Luiz Gonzaga Tone, Pablo Ferreira das Chagas, George A. Calin, Márcio Hideki Kodama, Carlos Alberto Oliveira de Biagi Junior, Carlos Alberto Scrideli, Jaqueline Carvalho de Oliveira, Silvia Regina Brandalise, José Andrés Yunes, Graziella Ribeiro de Sousa

Publikováno v: Hematology, Transfusion and Cell Therapy
Hematology, Transfusion and Cell Therapy, Volume: 43, Issue: 1, Pages: 28-34, Published: 26 MAR 2021
Hematology, Transfusion and Cell Therapy, Vol 43, Iss 1, Pp 28-34 (2021)

Aberrant expression of long non-coding RNAs (lncRNAs) has been detected in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA mapped on transcribed ultraconserved regions (T-UCRs) are little explored. The T-UCRs uc.112,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6b0f751c7b515cce48d6e66976d0c0
https://doi.org/10.1016/j.htct.2019.12.003