Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Graziella Pellegrini"'
Autor:
Vincenzo Giuseppe Genna, Davide Adamo, Giulia Galaverni, Fabio Lepore, Federica Boraldi, Daniela Quaglino, Filippo Lococo, Graziella Pellegrini
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Animal models are currently used in several fields of biomedical research as useful alternatives to human-based studies. However, the obtained results do not always effectively translate into clinical applications, due to interspecies anatom
Externí odkaz:
https://doaj.org/article/bc464e6faeaf488c97d684402cff3753
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151302- (2023)
Human corneal endothelial cells are organized in a tight mosaic of hexagonal cells and serve a critical function in maintaining corneal hydration and clear vision. Regeneration of the corneal endothelial tissue is hampered by its poor proliferative c
Externí odkaz:
https://doaj.org/article/e4056903e2b24435a7fbc12257e12017
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/9a9de99e901149b88e12c0fb0d3d8216
Autor:
Eleonora Maurizi, Davide Alessandro Martella, Davide Schiroli, Alessia Merra, Salman Ahmad Mustfa, Graziella Pellegrini, Claudio Macaluso, Ciro Chiappini
Publikováno v:
Advanced Science, Vol 9, Iss 33, Pp n/a-n/a (2022)
Abstract Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle‐mediated RNA interference therapy aimed at enha
Externí odkaz:
https://doaj.org/article/1522528582c141dcb678eb68dcccbb6f
Autor:
Davide Adamo, Giulia Galaverni, Vincenzo Giuseppe Genna, Filippo Lococo, Graziella Pellegrini
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Breathing, being predominantly an automatic action, is often taken for granted. However, respiratory diseases affect millions of people globally, emerging as one of the major causes of disability and death overall. Among the respiratory dysfunctions,
Externí odkaz:
https://doaj.org/article/e16ccc6757494cc6b3e169dc11100965
Autor:
Eleonora Maurizi, Davide Adamo, Federica Maria Magrelli, Giulia Galaverni, Eustachio Attico, Alessia Merra, Maria Benedetta Rizzarda Maffezzoni, Lorena Losi, Vincenzo Giuseppe Genna, Virginia Sceberras, Graziella Pellegrini
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
This article explores examples of successful and unsuccessful regenerative medicine on human epithelia. To evaluate the applications of the first regenerated tissues, the analysis of the past successes and failures addresses some pending issues and l
Externí odkaz:
https://doaj.org/article/f8062198679f42e9a4275138bb774c50
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Advanced therapy medicinal products (ATMPs) are the new frontier of medicine. Advanced therapy medicinal products are set out to satisfy unmet medical needs and provide new innovative, cutting-edge therapies for serious or life-threatening diseases,
Externí odkaz:
https://doaj.org/article/208cdc1a309b4095a72968e4ea5af1a7
Autor:
Jeremy Sugarman, Roger A. Barker, Ian Kerridge, Tamra Lysaght, Graziella Pellegrini, Douglas Sipp, Claire Tanner
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1021-1025 (2018)
Clinical uses of unproven stem cell-based interventions abound, yet many patients may be harmed by receiving them, raising complex ethical, economic, and societal concerns. Regulators, scientists, clinicians, professional societies, and patient advoc
Externí odkaz:
https://doaj.org/article/abf0ce7276fb40e58fd67d6679d3afa6
Autor:
Graziella Pellegrini, Michele De Luca
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1026-1033 (2018)
A feature distinguishing human hematopoietic and epithelial stem cells from other equally fascinating stem cells is perhaps their easier translation into a clinical setting. We have devoted nearly our entire scientific career in trying to turn our un
Externí odkaz:
https://doaj.org/article/f9ba6ff9c7004b639e229e5ece132bba
Autor:
Laura De Rosa, Alessia Secone Seconetti, Giorgio De Santis, Giovanni Pellacani, Tobias Hirsch, Tobias Rothoeft, Norbert Teig, Graziella Pellegrini, Johann W. Bauer, Michele De Luca
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2036-2049.e6 (2019)
Summary: Laminin 332-deficient junctional epidermolysis bullosa (JEB) is a severe genetic skin disease. JEB is marked by epidermal stem cell depletion, the origin of which is unknown. We show that dysregulation of the YAP and TAZ pathway underpins su
Externí odkaz:
https://doaj.org/article/c544bf23565742f0bcd647116e17cb70