Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Graziella El Khoury"'
Autor:
Antoine Rached, Georges Abi Rizk, Ali Barka Mahamat, Graziella El Khoury, Jeanne El Hage, Elena Harran, Virginie Lattard
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Anticoagulant rodenticides (AR) remain the most effective chemical substances used to control rodents in order to limit their agricultural and public health damage in both rural and urban environments. The emergence of genetically based resi
Externí odkaz:
https://doaj.org/article/3f8dcdd6cd3b4860a9d00e00fc82ebea
Autor:
Antoine Rached, Georges Abi Rizk, Ali Barka Mahamat, Graziella El Khoury, Jeanne El Hage, Elena Harran, Virginie Lattard
Publikováno v:
Scientific reports. 12(1)
Anticoagulant rodenticides (AR) remain the most effective chemical substances used to control rodents in order to limit their agricultural and public health damage in both rural and urban environments. The emergence of genetically based resistance to
Autor:
Graziella El Khoury, Gita Khalili Moghaddam, Christopher R. Lowe, Natália Cybelle Lima Oliveira, Lucas Sampaio Leite, Jennifer M. Versnel, José L. Lima-Filho
Publikováno v:
Sensors and Actuators B: Chemical. 270:216-222
The increasing consumption of illicit drugs has become a worldwide social and medical problem. Eradicating the supply and use of these drugs requires the development of devices that provide a fast, selective and simple response in seized powder sampl
Publikováno v:
Journal of Chromatography A. 1444:8-20
One challenge facing the production of glycoprotein therapeutics is the lack of stable and selective affinity ligands for their enrichment. Synthetic affinity ligands based on the solid phase multi-component Ugi reaction represent a desirable option,
Publikováno v:
Journal of Molecular Recognition. 29:232-238
Developing ligands capable of carbohydrate recognition has become increasingly important as the essential roles of glycoproteins and glycolipids in a diverse array of cellular signaling, pathophysiology, and immune response mechanisms are elucidated.
Autor:
Ana M. G. C. Dias, Christopher R. Lowe, Fatma Işık Üstok, Graziella El Khoury, Ricardo J. F. Branco, A. Cecília A. Roque, Ana Sofia Pina, Cláudia S. M. Fernandes
Publikováno v:
Journal of Chromatography A. 1418:83-93
The green fluorescent protein (GFP) is a useful indicator in a broad range of applications including cell biology, gene expression and biosensing. However, its full potential is hampered by the lack of a selective, mild and low-cost purification sche
Autor:
Basmah Khogeer, Chen Chen, Graziella El Khoury, Christopher R. Lowe, Shaleem I. Jacob, Kheng T Ng
Publikováno v:
Pharmaceutical Bioprocessing. 3:139-152
This article provides an overview of the current challenges and trends in bioprocessing, with a focus on recent advances in the affinity purification of the principal classes of biotherapeutics, including monoclonal antibodies, glycoproteins, vaccine
Autor:
Ana Sofia Pina, Márcia Guilherme, Christopher R. Lowe, Graziella El Khoury, Ricardo J. F. Branco, Cláudia S. M. Fernandes, A. Cecília A. Roque, Alice S. Pereira
Publikováno v:
ChemBioChem. 15:1423-1435
A novel affinity "tag-receptor" pair was developed as a generic platform for the purification of fusion proteins. The hexapeptide RKRKRK was selected as the affinity tag and fused to green fluorescent protein (GFP). The DNA fragments were designed, c
Publikováno v:
Biotechnology and Bioengineering. 110:3063-3069
This work describes the assessment of a de novo synthetic affinity ligand for recombinant human erythropoietin (rHuEPO), based on the multicomponent Ugi reaction. Four Ugi ligands were designed based on the X-ray crystallographic structure of the com
Publikováno v:
Journal of Molecular Recognition. 26:190-200
This work reports the development of a synthetic affinity adsorbent for immunoglobulins based on the Fab-binding domain of Streptococcal Protein G (SpG-domain III). The ligand (A2C7I1) was synthesized by the four-component Ugi reaction to generate a