Phosphoinositide-Specific Inositol Polyphosphate 5-Phosphatase IV Inhibits Inositide Trisphosphate Accumulation in Hypothalamus and Regulates Food Intake and Body Weight

Autor: Marcos H. Toyama, Maristela Cesquini, Lisete Compagno Michelini, José B.C. Carvalheira, Silvana Chiavegatto, Mario J.A. Saad, Graziela R. Stoppa, Licio A. Velloso, Daniela F. Bertelli, Jorge V. C. Felix, Eliana P. Araújo, Antonio C. Boschero, Miriam Gasparotto-Contessotto, Iscia Lopes-Cendes

Publikováno v: Endocrinology. 147:5385-5399

The enzyme phosphatidylinositol 3-kinase (PI3-kinase) exerts an important role in the transduction of the anorexigenic and thermogenic signals delivered by insulin and leptin to first-order neurons of the arcuate nucleus in the hypothalamus. The term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a54738fbfd0c3192af6ff641a95eafd
https://doi.org/10.1210/en.2006-0280

Polycythemia and Hb Coimbra [beta 99 (G1) Asp -> Glu] in Brazil

Autor: Graziela R. Stoppa, Elza Miyuki Kimura, Carmen Silvia Passos Lima, Satie H. Ogo, Juliana Martins, Dulcineia M. Albuquerque, Sara Terezinha Ollala Saad, Fernando Ferreira Costa, Maria de Fátima Sonati, André Fattori

Publikováno v: Genetics and Molecular Biology, Volume: 29, Issue: 2, Pages: 200-202, Published: 2006
Genetics and Molecular Biology, Vol 29, Iss 2, Pp 200-202 (2006)
Genetics and Molecular Biology v.29 n.2 2006
Genetics and Molecular Biology
Sociedade Brasileira de Genética (SBG)
instacron:SBG

We report the clinical and laboratory findings concerning three unrelated Brazilian patients investigated for polycythemia, whose definitive diagnosis could only be established after the presence of Hb Coimbra (b99 Asp ® Glu) was demonstrated. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f95d42bc53b43ff6af7ca2c5abeea1
https://doi.org/10.1590/s1415-47572006000200002

Effect of thiol reagents on functional properties and heme oxidation in the hemoglobin of Geochelone carbonaria

Autor: Maristela Cesquini, Graziela R. Stoppa, Marcio Alberto Torsoni, Satie H. Ogo, B. F. Barros, R. I. Viana

Publikováno v: IUBMB Life. 40:355-364

The reaction of thiol reagents with G. carbonaria hemoglobin was studied, and the oxygen equilibrium and kinetic of oxidation of derivatives determined. The oxygen affinity and kinetic of oxidation of hemoglobin derivatives were modified to various e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b68259115f925fd7fa911994c5f7e12
https://doi.org/10.1080/15216549600201842

Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats

Autor: Maristela Cesquini, Adriana Souza Torsoni, Patrícia O. Prada, Alex Souza, Mario J.A. Saad, Talita Romanatto, Marcio Alberto Torsoni, Graziela R. Stoppa, Licio A. Velloso

Publikováno v: Life sciences. 82(25-26)

The hypothalamic AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) pathway is known to play an important role in the control of food intake and energy expenditure. Here, we hypothesize that citrate, an intermediate metabolite, activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be866ed611547c3526ab2950c90ede8
https://pubmed.ncbi.nlm.nih.gov/18534630

t-BOOH-induced oxidative damage in sickle red blood cells and the role of flavonoids

Autor: Satie H. Ogo, Graziela R. Stoppa, Maristela Cesquini, Marcio Alberto Torsoni

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 57(3-4)

Sickle cell anemia is a genetic disease characterized byan increase in generation of reactive oxygen species, abnormal iron release and low antioxidant activity which can lead to cell injury. Several therapies have been used to decrease the oxidative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db85a19f26e42c79da859b3aef4a1691
https://pubmed.ncbi.nlm.nih.gov/12818473