Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Grazia Raffaella Tundo"'
Autor:
Monica Benvenuto, Valentina Angiolini, Chiara Focaccetti, Daniela Nardozi, Camilla Palumbo, Raffaele Carrano, Alessandra Rufini, Riccardo Bei, Martino Tony Miele, Patrizia Mancini, Giovanni Barillari, Mara Cirone, Elisabetta Ferretti, Grazia Raffaella Tundo, Luciano Mutti, Laura Masuelli, Roberto Bei
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background Malignant mesothelioma (MM) is a rare tumor with a dismal prognosis. The low efficacy of current treatment options highlights the urge to identify more effective therapies aimed at improving MM patients’ survival. Bortezomib (Bo
Externí odkaz:
https://doaj.org/article/d7fb152ec84945d69dcad913c8a97445
Autor:
Diego Sbardella, Grazia Raffaella Tundo, Alice Mecchia, Camilla Palumbo, Maria Grazia Atzori, Lauretta Levati, Alessandra Boccaccini, Anna Maria Caccuri, Paolo Cascio, Pedro Miguel Lacal, Grazia Graziani, Monica Varano, Massimiliano Coletta, Mariacristina Parravano
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-21 (2022)
Key Points High glucose quickly induces an atypical NF-kB pro-inflammatory program. CamKII phosphorylation of Rpt6 subunit of the proteasome stimulates IkBα turnover and p65-p50 release. Inhibition of either CamkII or proteasome blocks this pathway.
Externí odkaz:
https://doaj.org/article/2be4c18062b14db4b2e146a57820f67c
Autor:
Grazia Raffaella Tundo, Giuseppe Grasso, Marco Persico, Oleh Tkachuk, Francesco Bellia, Alessio Bocedi, Stefano Marini, Mariacristina Parravano, Grazia Graziani, Caterina Fattorusso, Diego Sbardella
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1492 (2023)
The insulin-degrading enzyme (IDE) is a Zn2+ peptidase originally discovered as the main enzyme involved in the degradation of insulin and other amyloidogenic peptides, such as the β-amyloid (Aβ) peptide. Therefore, a role for the IDE in the cure o
Externí odkaz:
https://doaj.org/article/faf2f74fbc4b43cdb79c98c5e36e62bf
Autor:
Monica Benvenuto, Sara Ciuffa, Chiara Focaccetti, Diego Sbardella, Sara Fazi, Manuel Scimeca, Grazia Raffaella Tundo, Giovanni Barillari, Maria Segni, Elena Bonanno, Vittorio Manzari, Andrea Modesti, Laura Masuelli, Massimo Coletta, Roberto Bei
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract Head and neck cancer (HNC) has frequently an aggressive course for the development of resistance to standard chemotherapy. Thus, the use of innovative therapeutic drugs is being assessed. Bortezomib is a proteasome inhibitor with anticancer
Externí odkaz:
https://doaj.org/article/fb341c343f084ed79de8be99b14fac49
Autor:
Grazia Raffaella Tundo, Diego Sbardella, Francesco Oddone, Giuseppe Grasso, Stefano Marini, Maria Grazia Atzori, Anna Maria Santoro, Danilo Milardi, Francesco Bellia, Gabriele Macari, Grazia Graziani, Fabio Polticelli, Paolo Cascio, Mariacristina Parravano, Massimo Coletta
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 315 (2022)
Carfilzomib is a last generation proteasome inhibitor (PI) with proven clinical efficacy in the treatment of relapsed/refractory multiple myeloma. This drug is considered to be extremely specific in inhibiting the chymotrypsin-like activity of the 20
Externí odkaz:
https://doaj.org/article/649f3bdc524743eb87fddf5a6256af99
Autor:
Diego Sbardella, Grazia Raffaella Tundo, Luisa Campagnolo, Giuseppe Valacchi, Augusto Orlandi, Paolo Curatolo, Giovanna Borsellino, Maurizio D’Esposito, Chiara Ciaccio, Silvia Di Cesare, Donato Di Pierro, Cinzia Galasso, Marta Elena Santarone, Joussef Hayek, Massimiliano Coletta, Stefano Marini
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ca4a5efff3834f5aae38c88c3d351b02
Autor:
Diego Sbardella, Grazia Raffaella Tundo, Francesca Sciandra, Manuela Bozzi, Magda Gioia, Chiara Ciaccio, Umberto Tarantino, Andrea Brancaccio, Massimo Coletta, Stefano Marini
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132455 (2015)
Insulin-Degrading-Enzyme (IDE) is a Zn2+-dependent peptidase highly conserved throughout evolution and ubiquitously distributed in mammalian tissues wherein it displays a prevalent cytosolic localization. We have recently demonstrated a novel Heat Sh
Externí odkaz:
https://doaj.org/article/481eb88fe5bc4f5c90b76bd7440c3ddf
Autor:
Marco Persico, Sara García-Viñuales, Anna Maria Santoro, Valeria Lanza, Grazia Raffaella Tundo, Diego Sbardella, Massimiliano Coletta, Valeria Romanucci, Armando Zarrelli, Giovanni Di Fabio, Caterina Fattorusso, Danilo Milardi
A reduced proteasome activity tiles excessive amyloid growth during the progress of protein conformational diseases (PCDs). Hence, the development of safe and effective proteasome enhancers represents an attractive target for the therapeutic treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2c0079556ea498783e8a6651335637
https://hdl.handle.net/11588/885593
https://hdl.handle.net/11588/885593
Autor:
Diego Ph.D. Diego Sba, Grazia Raffaella Tundo, Alice Mecchia, Camilla Palumbo, Maria Grazia Atzori, Lauretta Levati, Anna Maria Caccuri, Paolo Cascio, Pedro Lacal, Grazia Graziani, Monica Varano, Massimiliano Coletta, Maria Cristina Parravano
BackgroundDiabetic retinopathy (DR) is a microvascular complication of diabetes with a heavy impact on the life-quality of subjects and with a dramatic burden for health and economic systems on a global scale.Although the pathogenesis of DR is largel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68afcf3a6d9e319645db12b174dd5c16
https://doi.org/10.21203/rs.3.rs-1116573/v1
https://doi.org/10.21203/rs.3.rs-1116573/v1
Autor:
Diego Sbardella, Grazia Raffaella Tundo, Alice Mecchia, Camilla Palumbo, Maria Grazia Atzori, Lauretta Levati, Alessandra Boccaccini, Anna Maria Caccuri, Paolo Cascio, Pedro Miguel Lacal, Grazia Graziani, Monica Varano, Massimiliano Coletta, Mariacristina Parravano
Publikováno v:
Cellbioscience. 12(1)
Background Diabetic retinopathy (DR) is a microvascular complication of diabetes with a heavy impact on the quality of life of subjects and with a dramatic burden for health and economic systems on a global scale. Although the pathogenesis of DR is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae1cd42771460c1617087f4b425f2c3
https://pubmed.ncbi.nlm.nih.gov/35842713
https://pubmed.ncbi.nlm.nih.gov/35842713