Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Grazia, Serino"'
Autor:
Serena Mancarella, Isabella Gigante, Elena Pizzuto, Grazia Serino, Alberta Terzi, Francesco Dituri, Eugenio Maiorano, Leonardo Vincenti, Mario De Bellis, Francesco Ardito, Diego F. Calvisi, Gianluigi Giannelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background Cancer-associated fibroblasts (CAFs), mainly responsible for the desmoplastic reaction hallmark of intrahepatic Cholangiocarcinoma (iCCA), likely have a role in tumor aggressiveness and resistance to therapy, although the molecula
Externí odkaz:
https://doaj.org/article/f7201f2a93ed4fb2bd5f4cc907746a8b
Autor:
Maria Principia Scavo, Roberto Negro, Valentina Arrè, Nicoletta Depalo, Livianna Carrieri, Federica Rizzi, Rita Mastrogiacomo, Grazia Serino, Maria Notarnicola, Valentina De Nunzio, Tamara Lippolis, Pasqua Letizia Pesole, Sergio Coletta, Raffaele Armentano, Maria Lucia Curri, Gianluigi Giannelli
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-12 (2023)
Abstract Excessive toxic lipid accumulation in hepatocytes underlies the development of non-alcoholic fatty liver disease (NAFLD), phenotypically characterized by necrosis and steato-fibrosis, whose molecular mechanism is not yet fully understood. Pa
Externí odkaz:
https://doaj.org/article/32f652c194f34c6ead4ebfd1b778937d
Autor:
Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto, Gianluigi Giannelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage. ATX levels are directly
Externí odkaz:
https://doaj.org/article/bc5b94d5541c4e2db10ab31f71fec14a
Autor:
Simone Lasagni, Rosina Maria Critelli, Fabiola Milosa, Dario Saltini, Filippo Schepis, Adriana Romanzi, Francesco Dituri, Grazia Serino, Lorenza Di Marco, Alessandra Pivetti, Filippo Scianò, Gianluigi Giannelli, Erica Villa
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1424 (2024)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. Curative treatments are available to a minority of patients, as HCC is often diagnosed at an advanced stage. For patients with unresectable and multifocal HCC, tyro
Externí odkaz:
https://doaj.org/article/5be285723f8a4504831bceec6c6358d2
Autor:
Valentina Arrè, Rita Mastrogiacomo, Francesco Balestra, Grazia Serino, Federica Viti, Federica Rizzi, Maria Lucia Curri, Gianluigi Giannelli, Nicoletta Depalo, Maria Principia Scavo
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 567 (2024)
Extracellular vesicles (EVs), acting as inherent nanocarriers adept at transporting a range of different biological molecules such as proteins, lipids, and genetic material, exhibit diverse functions within the gastroenteric tract. In states of norma
Externí odkaz:
https://doaj.org/article/7f3f6585d9a044fb9a05d27d44a01827
Autor:
Serena Mancarella, Isabella Gigante, Grazia Serino, Elena Pizzuto, Francesco Dituri, Maria F. Valentini, Jingxiao Wang, Xin Chen, Raffaele Armentano, Diego F. Calvisi, Gianluigi Giannelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-14 (2022)
Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant tumor characterized by an intensive desmoplastic reaction due to the exaggerated presence of the extracellular (ECM) matrix components. Liver fibroblasts close to the tu
Externí odkaz:
https://doaj.org/article/04d9818126634bcbb9a920a39c75e01a
Autor:
Rut Espinosa-Sotelo, Noel P. Fusté, Irene Peñuelas-Haro, Ania Alay, Gabriel Pons, Xènia Almodóvar, Júlia Albaladejo, Ismael Sánchez-Vera, Ricard Bonilla-Amadeo, Francesco Dituri, Grazia Serino, Emilio Ramos, Teresa Serrano, Mariona Calvo, María Luz Martínez-Chantar, Gianluigi Giannelli, Esther Bertran, Isabel Fabregat
Publikováno v:
Redox Biology, Vol 65, Iss , Pp 102818- (2023)
The NADPH oxidase NOX4 has been proposed as necessary for the apoptosis induced by the Transforming Growth Factor-beta (TGF-β) in hepatocytes and hepatocellular carcinoma (HCC) cells. However, whether NOX4 is required for TGF-β-induced canonical (S
Externí odkaz:
https://doaj.org/article/cd27014ed9c6426f9cb7e3119cb7abcb
Autor:
Serena Mancarella, Grazia Serino, Isabella Gigante, Antonio Cigliano, Silvia Ribback, Paola Sanese, Valentina Grossi, Cristiano Simone, Raffaele Armentano, Matthias Evert, Diego F. Calvisi, Gianluigi Giannelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Intrahepatic Cholangiocarcinoma (iCCA) is characterized by a strong stromal reaction playing a role in tumor progression. Thymus cell antigen 1 (THY1), also called Cluster of Differentiation 90 (CD90), is a key regulator of cell
Externí odkaz:
https://doaj.org/article/b6b55b840ca44c9c9951bdeb98bc1f08
Autor:
Viviana Scalavino, Emanuele Piccinno, Anna Maria Valentini, Nicolò Schena, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino
Publikováno v:
Cells, Vol 12, Iss 17, p 2184 (2023)
Inflammasomes are multiprotein complexes expressed by immune cells in response to distinct stimuli that trigger inflammatory responses and the release of pro-inflammatory cytokines. Evidence suggests a different role of inflammasome NLRP3 in IBD. NLR
Externí odkaz:
https://doaj.org/article/18b64a7cfa34416fa1965cc6e585e6ac
Autor:
Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto, Gianluigi Giannelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/3860ae793f9c47ad98e64cca50461ccd