Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Grayson Burdon"'
Autor:
Cristiana Iosef, Albert J. Pedroza, Jason Z. Cui, Alex R. Dalal, Mamoru Arakawa, Yasushi Tashima, Tiffany K. Koyano, Grayson Burdon, Samantha M. P. Churovich, Joshua O. Orrick, Mitchel Pariani, Michael P. Fischbein
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1 gene that produces wide disease phenotypic variability. The lack of ample genotype–phenotype correlation hinders translational study development aimed at
Externí odkaz:
https://doaj.org/article/5f51d52d33394a82b68928fa4c927f13
Autor:
Yasushi Tashima, Hao He, Jason Z. Cui, Albert J. Pedroza, Ken Nakamura, Nobu Yokoyama, Cristiana Iosef, Grayson Burdon, Tiffany Koyano, Atsushi Yamaguchi, Michael P. Fischbein
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 20 (2020)
Background Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared with females. The role androgens play during Marfan syndrome aneurysm development in males remains unknown. We hypothesized that androgens
Externí odkaz:
https://doaj.org/article/350c3d55cf2d4cf18ea4784b97464174
Autor:
Tetsuya Sato, Mamoru Arakawa, Yasushi Tashima, Eitoshi Tsuboi, Grayson Burdon, Jeffrey Trojan, Tiffany Koyano, Young‐Nam Youn, Kiril Penov, Albert J. Pedroza, Mohammad Shabazzi, Itai Palmon, Marie Noel Nguyen, Andrew J. Connolly, Atsushi Yamaguchi, Michael P. Fischbein
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 21 (2018)
Background Statins reduce aneurysm growth in mouse models of Marfan syndrome, although the mechanism is unknown. In addition to reducing cholesterol, statins block farnesylation and geranylgeranylation, which participate in membrane‐bound G‐prote
Externí odkaz:
https://doaj.org/article/2fd36db5b2c641788e5c50564d7f9118
Autor:
Itai Palmon, Yasushi Tashima, Paul Chang, Tiffany K Koyano, Cristiana Iosef, Grayson Burdon, Michael P. Fischbein, Jason Z. Cui, Adam J. Rubin, Jeffrey Trojan, Kevin J Jaatinen, G. Berry, Albert J. Pedroza
Publikováno v:
Journal of Cellular and Molecular Medicine
Aortic root aneurysm formation is a cardinal feature of Marfan syndrome (MFS) and likely TGF‐β driven via Smad (canonical) and ERK (non‐canonical) signalling. The current study assesses human MFS vascular smooth muscle cell (SMC) phenotype, focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f334f789257a79038a98893162423f13
http://europepmc.org/articles/PMC7011150
http://europepmc.org/articles/PMC7011150
Autor:
Michael P. Fischbein, Cristiana Iosef, Yasushi Tashima, Grayson Burdon, Joshua O Orrick, Alex R. Dalal, Albert J. Pedroza, Tiffany K Koyano, Jason Z. Cui, Mitchel Pariani, Mamoru Arakawa, Samantha Churovich
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1 gene that produces wide disease phenotypic variability. The lack of ample genotype–phenotype correlation hinders translational study development aimed at improvin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a5d6aeb339065ffd213f318a47b9df
https://doi.org/10.1038/s41598-020-77274-w
https://doi.org/10.1038/s41598-020-77274-w
Autor:
Cristiana Iosef, Atsushi Yamaguchi, Michael P. Fischbein, Ken Nakamura, Albert J. Pedroza, Jason Z. Cui, Nobu Yokoyama, Tiffany K Koyano, Yasushi Tashima, Hao He, Grayson Burdon
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared with females. The role androgens play during Marfan syndrome aneurysm development in males remains unknown. We hypothesized that androgens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e60c45651fc7357403c18dd5349856
https://doi.org/10.1161/jaha.119.015773
https://doi.org/10.1161/jaha.119.015773
Autor:
Chenyu Li, David N. Debruyne, Julia Spencer, Vidushi Kapoor, Lily Y. Liu, Bo Zhou, Utsav Pandey, Moiz Bootwalla, Dejerianne Ostrow, Dennis T Maglinte, David Ruble, Alex Ryutov, Lishuang Shen, Lucie Lee, Rounak Feigelman, Grayson Burdon, Jeffrey Liu, Alejandra Oliva, Adam Borcherding, Hongdong Tan, Alexander E. Urban, Xiaowu Gai, Jennifer Dien Bard, Guoying Liu, Zhitong Liu
Many detection methods have been used or reported for the diagnosis and/or surveillance of SARS-CoV-2. Among them, reverse transcription polymerase chain reaction (RT-PCR) is the most sensitive, claiming detection of about 5 copies of viruses. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80c717901fc7b413dc4021907f350a9f
https://doi.org/10.1101/2020.03.12.988246
https://doi.org/10.1101/2020.03.12.988246
Autor:
Grayson Burdon, Lily Liu, Guoying Liu, Julia Spencer, Jeff C. Liu, Rounak Feigelman, Zhitong Liu, David Debruyne, Lucie Lee, Vidushi Kapoor, Chenyu Li
Publikováno v:
Cancer Research. 81:455-455
Gene fusions, which are usually caused by chromosomal rearrangements, are frequently associated with various cancers. Detection of fusion mutations is an important part of cancer management, and are usually detected in RNA purified from biopsies of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9186837ec615599db22d4bbbcaee2c7
https://doi.org/10.1158/1538-7445.am2021-455
https://doi.org/10.1158/1538-7445.am2021-455
Autor:
Tiffany K Koyano, Andrew J. Connolly, Michael P. Fischbein, Young Min Kim, Uwe Raaz, Albert J. Pedroza, Grayson Burdon, Mamoru Arakawa, Kiril Penov, Fabian Emrich, Cristiana Iosef, Nathan Dhablania
Publikováno v:
Journal of cellular and molecular medicine, vol 23, iss 10
Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine
Marfan syndrome (MFS) is a connective tissue disorder that results in aortic root aneurysm formation. Reactive oxygen species (ROS) seem to play a role in aortic wall remodelling in MFS, although the mechanism remains unknown. MFS Fbn1C1039G/+ mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc96316003a7b91d191e7287281437b
https://escholarship.org/uc/item/2mt5b604
https://escholarship.org/uc/item/2mt5b604
Autor:
Guoying Liu, Jeff C. Liu, Rounak Feigelman, Zhitong Liu, David Debruyne, Vidushi Kapoor, Lily Y. Liu, Chenyu Li, Grayson Burdon, Lucie Lee, Julia Spencer
Publikováno v:
Journal of Clinical Oncology. 39:e15029-e15029
e15029 Background: Gene fusions are usually caused by chromosomal rearrangements and frequently associated with various cancers. Detection of fusion mutations is an important part of cancer management, and are usually detected in RNA purified from bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a373eff0a7d44b7a28e51a1be919835
https://doi.org/10.1200/jco.2021.39.15_suppl.e15029
https://doi.org/10.1200/jco.2021.39.15_suppl.e15029