Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type i IFN Signaling

Autor: York, AG, Williams, KJ, Argus, JP, Zhou, QD, Brar, G, Vergnes, L, Gray, EE, Zhen, A, Wu, NC, Yamada, DH, Cunningham, CR, Tarling, EJ, Wilks, MQ, Casero, D, Gray, DH, Yu, AK, Wang, ES, Brooks, DG, Sun, R, Kitchen, SG, Wu, TT, Reue, K, Stetson, DB, Bensinger, SJ

Publikováno v: Cell, vol 163, iss 7

Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I interferon (IFN) signaling shifts the balance of these programs by decreasing synthesis and increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2ab194542ef1f212fcff438c13935a69
https://escholarship.org/uc/item/2c63f4mn

Deficiency in IL-17-committed Vγ4+ γδ T cells in a spontaneous Sox13-mutant CD45.1+ congenic mouse substrain provides protection from dermatitis

Autor: Cyster, Jason, Gray, EE, Ramírez-Valle, F, Xu, Y, Wu, S, Wu, Z, Karjalainen, KE, Cyster, JG

Publikováno v: Cyster, Jason; Gray, EE; Ramírez-Valle, F; Xu, Y; Wu, S; Wu, Z; et al.(2013). Deficiency in IL-17-committed Vγ4+ γδ T cells in a spontaneous Sox13-mutant CD45.1+ congenic mouse substrain provides protection from dermatitis. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/605115bv

Interleukin 17 (IL-17)-committed γδ T cells (γδT17 cells) participate in many immune responses, but their developmental requirements and subset specific functions remain poorly understood. Here we report that a commonly used CD45.1+ congenic C57B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::6b9259e01f5cfc22bb6d6dd1f5f6a5a5
http://www.escholarship.org/uc/item/605115bv

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Schwann cell-secreted PGE 2 promotes sensory neuron excitability during development.

Autor: Kantarci H; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Elvira PD; Department of Chemistry, Stanford University, Stanford, CA 94305, USA., Thottumkara AP; Department of Chemistry, Stanford University, Stanford, CA 94305, USA., O'Connell EM; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Iyer M; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Donovan LJ; Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Dugan MQ; Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Ambiel N; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Granados A; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Zeng H; Transgenic, Knockout and Tumor model Center (TKTC), Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Saw NL; Behavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA 94305, USA., Brosius Lutz A; Department of Obstetrics and Gynecology, University Hospital, Bern, Switzerland., Sloan SA; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Gray EE; Department of Chemistry, Stanford University, Stanford, CA 94305, USA., Tran KV; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Vichare A; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Yeh AK; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Münch AE; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Huber M; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Agrawal A; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Morri M; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Zhong H; Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA., Shamloo M; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Behavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA 94305, USA., Anderson TA; Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Tawfik VL; Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Du Bois J; Department of Chemistry, Stanford University, Stanford, CA 94305, USA. Electronic address: jdubois@stanford.edu., Zuchero JB; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: zuchero@stanford.edu.

Publikováno v: Cell [Cell] 2024 Aug 22; Vol. 187 (17), pp. 4690-4712.e30. Date of Electronic Publication: 2024 Aug 13.