Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Gray D. Shaw"'
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Akademický článek
Arterial Platelet Adhesion in Atherosclerosis‐Prone Arteries of Obese, Insulin‐Resistant Nonhuman Primates
Autor: Eran Brown, Koya Ozawa, Federico Moccetti, Amanda Vinson, James Hodovan, The Anh Nguyen, Lindsay Bader, José A. López, Paul Kievit, Gray D. Shaw, Dominic W. Chung, Warren Osborn, Xiaoyun Fu, Junmei Chen, Jonathan R. Lindner
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 9 (2021)
Background Platelet–endothelial interactions are thought to contribute to early atherogenesis. These interactions are potentiated by oxidative stress. We used in vivo molecular imaging to test the hypothesis that platelet–endothelial interactions
Externí odkaz: https://doaj.org/article/d3eb1c60c5774fd1bb4798a532628291
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Arterial Platelet Adhesion in Atherosclerosis‐Prone Arteries of Obese, Insulin‐Resistant Nonhuman Primates
Autor: Federico Moccetti, Xiaoyun Fu, James Hodovan, José A. López, Lindsay Bader, Dominic W. Chung, Koya Ozawa, Gray D. Shaw, Eran Brown, Warren Osborn, Junmei Chen, Paul Kievit, Jonathan R. Lindner, Amanda Vinson
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Platelet–endothelial interactions are thought to contribute to early atherogenesis. These interactions are potentiated by oxidative stress. We used in vivo molecular imaging to test the hypothesis that platelet–endothelial interactions
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1ceb56080b5918baeafad6edc10c54
https://doi.org/10.1161/jaha.120.019413
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Tandem P-selectin glycoprotein ligand immunoglobulin prevents lung vaso-occlusion in sickle cell disease mice
Autor: Egemen Tutuncuoglu, Prithu Sundd, Tirthadipa Pradhan-Sundd, Gray D. Shaw, Jesús Tejero, Ravi Vats
Publikováno v: Exp Hematol
Sickle cell disease (SCD) is a monogenic disorder, estimated to affect over three million people worldwide(1,2). Acute systemic painful vaso-occlusive episode (VOE) is the primary reason for emergency medical care among SCD patients(3). VOE may also
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fae95806098c652893e207e83bfb2a
https://pubmed.ncbi.nlm.nih.gov/32243995
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A Soluble Form of P Selectin Glycoprotein Ligand 1 Requires Signaling by Nuclear Factor Erythroid 2–Related Factor 2 to Protect Liver Transplant Endothelial Cells Against Ischemia–Reperfusion Injury
Autor: Shufa Zheng, Yuanxing Liu, Jerzy W. Kupiec-Weglinski, Cheng Zhang, Ronald W. Busuttil, Haofeng Ji, Xiu-Da Shen, Gray D. Shaw, Yu Zhang, Feng Gao, Shoichi Kageyama
Publikováno v: American Journal of Transplantation. 17:1462-1475
Liver endothelial cell (LEC) damage is essential in the pathogenesis of ischemia-reperfusion injury (IRI) in transplant recipients. We analyzed the mechanism of LEC resistance against IRI by using a novel recombinant soluble form of P selectin glycop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70923f053c09e4ccf2f6ae7c2230ed31
https://doi.org/10.1111/ajt.14159
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Tandem P-Selectin Glycoprotein Ligand Immunoglobulin Prevents Lung Vaso-Occlusion in SCD Mice
Autor: Gray D. Shaw, Ravi Vats, Egemen Tutuncuoglu, Prithu Sundd, Jesús Tejero
Publikováno v: Blood. 132:2364-2364
Introduction: Sickle cell disease (SCD) is an autosomal-recessive-genetic disorder, which leads to red blood cell sickling, hemolysis and vaso-occlusion. Acute systemic painful vaso-occlusive crisis (VOC) is the predominant pathophysiology requiring
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed411da40601b236c3771140b84c4698
https://doi.org/10.1182/blood-2018-99-116742
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Characterization of the Novel P-Selectin Inhibitor PSI-697 [2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] Quinoline-4-carboxylic acid] in Vitro and in Rodent Models of Vascular Inflammation and Thrombosis
Autor: Robert G. Schaub, Valerie Clerin, David L. Crandall, Gray D. Shaw, Thomas M. Antrilli, Natalia Sushkova, Laura L. Carter, Christine Resmini, Patricia W. Bedard, Kristin Janz, James K. Hennan, Silvano DeBernardo, James C. Keith, Neelu Kaila, Qin Wang, Boris Tchernychev
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 324:497-506
P-selectin plays a significant and well documented role in vascular disease by mediating leukocyte and platelet rolling and adhesion. This study characterizes the in vitro activity, pharmacokinetic properties, and the anti-inflammatory and antithromb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3f0969afcb1b3977097a3ac40ce1a3
https://doi.org/10.1124/jpet.107.128124
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Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis
Autor: Thomas R. Meier, Thomas W. Wakefield, Patricia W. Bedard, Neelu Kaila, Angela E. Hawley, Gray D. Shaw, Daniel D. Myers, Shirley K. Wrobleski, Robert G. Schaub, Peter K. Henke
Publikováno v: Journal of Vascular Surgery. 44:625-632
BackgroundVein wall injury after thrombosis is multifactorial but seems dependent on thrombus and local thrombotic and inflammatory mechanisms. We hypothesized that inhibition of vein wall injury through reduction of thrombotic and inflammatory event
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a40dbf37d0e354213ed67dbea0ca71a
https://doi.org/10.1016/j.jvs.2006.05.021
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