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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.

Autor: John AE; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Graves RH; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Pun KT; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Vitulli G; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Forty EJ; Centre for Inflammation and Tissue Repair, University College London, London, UK., Mercer PF; Centre for Inflammation and Tissue Repair, University College London, London, UK., Morrell JL; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Barrett JW; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Rogers RF; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Hafeji M; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Bibby LI; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Gower E; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Morrison VS; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Man Y; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Roper JA; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Luckett JC; Radiological Sciences, University of Nottingham, Nottingham, UK., Borthwick LA; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Barksby BS; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Burgoyne RA; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Barnes R; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Le J; Drug Design and Selection - Molecular Design, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Flint DJ; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK., Pyne S; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK., Habgood A; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Organ LA; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Joseph C; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Edwards-Pritchard RC; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Maher TM; NIHR Respiratory Clinical Research Facility, Royal Brompton Hospital, London, UK.; Fibrosis Research Group, National Heart and Lung Institute, Imperial College, London, UK., Fisher AJ; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.; Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS, Foundation Trust, Newcastle upon Tyne, UK., Gudmann NS; Nordic Bioscience A/S, Biomarkers and Research, Herlev Hovedgade 205-207, Herlev, Denmark., Leeming DJ; Nordic Bioscience A/S, Biomarkers and Research, Herlev Hovedgade 205-207, Herlev, Denmark., Chambers RC; Centre for Inflammation and Tissue Repair, University College London, London, UK., Lukey PT; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Marshall RP; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Macdonald SJF; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Jenkins RG; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK. gisli.jenkins@nottingham.ac.uk., Slack RJ; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK.

Publikováno v: Nature communications [Nat Commun] 2020 Sep 16; Vol. 11 (1), pp. 4659. Date of Electronic Publication: 2020 Sep 16.

2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis.

Autor: Shukla L; Department of Medicinal Chemistry, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Ajram LA; Department of Respiratory Biology, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Begg M; Department of Respiratory Biology, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Evans B; Department of Medicinal Chemistry, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Graves RH; Department of Drug Metabolism and Pharmacokinetics, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Hodgson ST; Department of Medicinal Chemistry, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Lynn SM; UK Analytical Chemistry, Platform Technology & Science, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Miah AH; Department of Medicinal Chemistry, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Percy JM; WestCHEM Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, United Kingdom., Procopiou PA; Department of Medicinal Chemistry, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom. Electronic address: pan.a.procopiou@gsk.com., Richards SA; UK Analytical Chemistry, Platform Technology & Science, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Slack RJ; Department of Respiratory Biology, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2016 Jun 10; Vol. 115, pp. 14-25. Date of Electronic Publication: 2016 Feb 27.

Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.

Autor: Procopiou PA; Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom. pan.a.procopiou@gsk.com, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP, Hill AP, Hobbs H, Hodgson ST, Jumeaux C, Lacroix YM, Miah AH, Morriss KM, Needham D, Sheriff EB, Slack RJ, Smith CE, Sollis SL, Staton H

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2013 Mar 14; Vol. 56 (5), pp. 1946-60. Date of Electronic Publication: 2013 Feb 27.

Fluoroscopy-assisted plantar fasciotomy and calcaneal exostectomy: a retrospective study and comparison of surgical techniques.

Autor: Graves RH 3rd; Department of Podiatric Surgery, Fountain Valley Regional Hospital, CA., Levin DR, Giacopelli J, White PR, Russell RD

Publikováno v: The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons [J Foot Ankle Surg] 1994 Sep-Oct; Vol. 33 (5), pp. 475-81.