A H3K27M-targeted vaccine in adults with diffuse midline glioma.

Autor: Grassl N; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Poschke I; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Immune Monitoring Unit, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Lindner K; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Immune Monitoring Unit, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Bunse L; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Mildenberger I; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Boschert T; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Immune Monitoring Unit, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Helmholtz Institute for Translational Oncology (HI-TRON) Mainz, German Cancer Research Center, Mainz, Germany., Jähne K; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Green EW; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Hülsmeyer I; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Immune Monitoring Unit, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Jünger S; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Immune Monitoring Unit, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Kessler T; Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany., Suwala AK; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; DKTK Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Eisele P; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany., Breckwoldt MO; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Vajkoczy P; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Berlin, Germany., Grauer OM; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Herrlinger U; Division of Clinical Neurooncology, Department of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany., Tonn JC; Department of Neurosurgery, University of Munich LMU, Munich, Germany., Denk M; Institute of Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany., Sahm F; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; DKTK Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bendszus M; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., von Deimling A; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; DKTK Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Winkler F; Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany., Wick W; Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany., Platten M; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.platten@dkfz-heidelberg.de.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany. m.platten@dkfz-heidelberg.de.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany. m.platten@dkfz-heidelberg.de.; Immune Monitoring Unit, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany. m.platten@dkfz-heidelberg.de.; Helmholtz Institute for Translational Oncology (HI-TRON) Mainz, German Cancer Research Center, Mainz, Germany. m.platten@dkfz-heidelberg.de., Sahm K; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. k.sahm@dkfz-heidelberg.de.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany. k.sahm@dkfz-heidelberg.de.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany. k.sahm@dkfz-heidelberg.de.

Publikováno v: Nature medicine [Nat Med] 2023 Oct; Vol. 29 (10), pp. 2586-2592. Date of Electronic Publication: 2023 Sep 21.

Molecular predictors for decitabine efficacy in meningiomas - a pilot study.

Autor: Spille DC; Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, North Rhine-Westphalia, Germany., Thomas C; Institute of Neuropathology, University Hospital Münster, Münster, North Rhine-Westphalia, Germany., Wagner A; Institute of Neuropathology, University Hospital Münster, Münster, North Rhine-Westphalia, Germany., Grauer OM; Department of Neurology, University of Münster, Münster, North Rhine-Westphalia, Germany., Canisius J; Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, North Rhine-Westphalia, Germany., Bunk EC; Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, North Rhine-Westphalia, Germany., Stummer W; Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, North Rhine-Westphalia, Germany., Eich HT; Department of Radiation Oncology, University Hospital Münster, Münster, North Rhine-Westphalia, Germany., Paulus W; Institute of Neuropathology, University Hospital Münster, Münster, North Rhine-Westphalia, Germany., Senner V; Institute of Neuropathology, University Hospital Münster, Münster, North Rhine-Westphalia, Germany., Brokinkel B; Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, North Rhine-Westphalia, Germany. benjamin.brokinkel@mail.de.; Institute of Neuropathology, University Hospital Münster, Münster, North Rhine-Westphalia, Germany. benjamin.brokinkel@mail.de.

Publikováno v: Journal of neuro-oncology [J Neurooncol] 2023 Aug; Vol. 164 (1), pp. 97-105. Date of Electronic Publication: 2023 Jul 21.

A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies.

Autor: Strippel C; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Herrera-Rivero M; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany., Wendorff M; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Tietz AK; Department of Neurology, University of Kiel, Kiel, Germany., Degenhardt F; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Witten A; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany., Schroeter C; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Nelke C; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Golombeck KS; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Madlener M; Department of Neurology, University of Cologne, Cologne, Germany., Rüber T; Department of Epileptology, University of Bonn, Bonn, Germany.; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany., Ernst L; Department of Epileptology, University of Bonn, Bonn, Germany., Racz A; Department of Epileptology, University of Bonn, Bonn, Germany., Baumgartner T; Department of Epileptology, University of Bonn, Bonn, Germany., Widman G; Department of Epileptology, University of Bonn, Bonn, Germany., Doppler K; Department of Neurology, University of Würzburg, Würzburg, Germany., Thaler F; Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.; Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany., Siebenbrodt K; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany., Dik A; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Kerin C; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Räuber S; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Gallus M; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Kovac S; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Grauer OM; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Grimm A; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Prüss H; Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany., Wickel J; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany., Geis C; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany., Lewerenz J; Department of Neurology, Ulm University, Ulm, Germany., Goebels N; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Ringelstein M; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.; Center for Neurology and Neuropsychiatry, LVR Klinikum, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Menge T; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.; Center for Neurology and Neuropsychiatry, LVR Klinikum, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Tackenberg B; Department of Neurology, University of Marburg/Gießen, Marburg, Germany., Kellinghaus C; Department of Neurology, Klinikum Osnabrück, Osnabrück, Germany., Bien CG; Department of Epileptology (Krankenhaus Mara), Bielefeld University, Medical School, Campus Bielefeld-Bethel, Bielefeld, Germany., Kraft A; Martha Maria Hospital Halle, Halle, Germany., Zettl U; Department of Neurology, University of Rostock, Rostock, Germany., Ismail FS; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany., Ayzenberg I; Department of Neurology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.; Department of Neurology, St Josefs Krankenhaus Bochum, Ruhr University Bochum, Bochum, Germany., Urbanek C; Department of Neurology, Ludwigshafen Hospital, Ludwigshafen, Germany., Sühs KW; Department of Neurology, University Hospital, MHH, Hannover, Germany., Tauber SC; Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany., Mues S; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.; Department of Neurology, University Hospital Dresden, Dresden, Germany., Körtvélyessy P; Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.; Department of Neurology, University Hospital Magdeburg, Magdeburg, Germany., Markewitz R; Neuroimmunology, Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck, Germany., Paliantonis A; Department of Neurology, Alfred-Krupp Hospital, Essen, Germany., Elger CE; Department of Epileptology, University of Bonn, Bonn, Germany., Surges R; Department of Epileptology, University of Bonn, Bonn, Germany., Sommer C; Department of Neurology, University of Würzburg, Würzburg, Germany., Kümpfel T; Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.; Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany., Gross CC; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Lerche H; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Wellmer J; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany., Quesada CM; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Then Bergh F; Department of Neurology, University of Leipzig, Leipzig, Germany., Wandinger KP; Neuroimmunology, Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck, Germany., Becker AJ; Section of Translational Epileptology, Institute of Neuropathology, University of Bonn, Bonn, Germany., Kunz WS; Department of Epileptology, University of Bonn, Bonn, Germany., Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Malter MP; Department of Neurology, University of Cologne, Cologne, Germany., Rosenow F; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany., Wiendl H; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Kuhlenbäumer G; Department of Neurology, University of Kiel, Kiel, Germany., Leypoldt F; Department of Neurology, University of Kiel, Kiel, Germany.; Neuroimmunology, Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck, Germany., Lieb W; Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Meuth SG; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany., Stoll M; Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany., Melzer N; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.

Publikováno v: Brain : a journal of neurology [Brain] 2023 Mar 01; Vol. 146 (3), pp. 977-990.

Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma.

Autor: Heming M; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany., Haessner S; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany., Wolbert J; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany., Lu IN; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany., Li X; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany.; The Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Brokinkel B; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Müther M; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Holling M; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Stummer W; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Thomas C; Institute of Neuropathology, University Hospital Münster, Münster, Germany., Schulte-Mecklenbeck A; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany., de Faria F; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Stoeckius M; New York Genome Center, New York, NY, USA., Hailfinger S; Department of Medicine A, Hematology, Oncology, and Pneumology, University Hospital Münster, Münster, Germany., Lenz G; Department of Medicine A, Hematology, Oncology, and Pneumology, University Hospital Münster, Münster, Germany., Kerl K; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Wiendl H; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany., Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany. gerd.meyerzuhoerste@ukmuenster.de., Grauer OM; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1, 48149, Münster, Germany. oliver.grauer@ukmuenster.de.

Publikováno v: Genome medicine [Genome Med] 2022 Sep 24; Vol. 14 (1), pp. 109. Date of Electronic Publication: 2022 Sep 24.

In Vivo Quantitative Imaging of Glioma Heterogeneity Employing Positron Emission Tomography.

Autor: Barca C; European Institute for Molecular Imaging (EIMI), University of Münster, D-48149 Münster, Germany., Foray C; European Institute for Molecular Imaging (EIMI), University of Münster, D-48149 Münster, Germany., Zinnhardt B; European Institute for Molecular Imaging (EIMI), University of Münster, D-48149 Münster, Germany.; Biomarkers & Translational Technologies (BTT), Pharma Research & Early Development (pRED), F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland., Winkeler A; Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Service Hospitalier Frédéric Joliot, F-91401 Orsay, France., Herrlinger U; Division of Clinical Neuro-Oncology, Department of Neurology, University Hospital Bonn, D-53105 Bonn, Germany.; Centre of Integrated Oncology (CIO), University Hospital Bonn, D-53127 Bonn, Germany., Grauer OM; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, D-48149 Münster, Germany., Jacobs AH; European Institute for Molecular Imaging (EIMI), University of Münster, D-48149 Münster, Germany.; Centre of Integrated Oncology (CIO), University Hospital Bonn, D-53127 Bonn, Germany.; Department of Geriatrics with Neurology, Johanniter Hospital, D-53113 Bonn, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2022 Jun 27; Vol. 14 (13). Date of Electronic Publication: 2022 Jun 27.