RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

Autor: Dietmar Schmitz, Rosenmund T, Gülçin Vardar, Claudia G Willmes, Alexander Stumpf, Marta Maglione, Alexander M. Walter, Marisa M Brockmann, Benjamin R. Rost, Haucke, Stephan J. Sigrist, Suneel Reddy-Alla, Christian Rosenmund, Thorsten Trimbuch, Britta J. Eickholt, Maria Pangalos, Grauel Mk

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 113(41): 11615–11620
Proceedings of the National Academy of Sciences of the United States of America 113(41), 11615-11620 (2016). doi:10.1073/pnas.1605256113

Significance Highly regulated and precise positioning of Ca 2+ channels at the active zone (AZ) controls Ca 2+ nanodomains at release sites. Their exact localization affects vesicular release probability (P VR ) and is important for proper synaptic t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3d9c93a983f55efeeb5aa8dfeecda6
https://doi.org/10.1073/pnas.1605256113

Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.

Autor: Patzke C; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA. Electronic address: patzke@stanford.edu., Brockmann MM; Institut für Neurophysiologie, Charité Universitätsmedizin, 10117 Berlin, Germany., Dai J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Gan KJ; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Grauel MK; Institut für Neurophysiologie, Charité Universitätsmedizin, 10117 Berlin, Germany., Fenske P; Institut für Neurophysiologie, Charité Universitätsmedizin, 10117 Berlin, Germany., Liu Y; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Acuna C; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Rosenmund C; Institut für Neurophysiologie, Charité Universitätsmedizin, 10117 Berlin, Germany., Südhof TC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA.

Publikováno v: Cell [Cell] 2019 Oct 03; Vol. 179 (2), pp. 498-513.e22.

Micropatterned Thermoresponsive Cell Culture Substrates for Dynamically Controlling Neurite Outgrowth and Neuronal Connectivity in Vitro.

Autor: Behm LVJ; Fraunhofer Institute for Cell Therapy and Immunology, Branch Potsdam IZI-BB, Am Muehlenberg 13, 14476 Potsdam, Germany., Gerike S; Fraunhofer Institute for Cell Therapy and Immunology, Branch Potsdam IZI-BB, Am Muehlenberg 13, 14476 Potsdam, Germany., Grauel MK; Institute of Neurophysiology, Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany., Uhlig K; Fraunhofer Institute for Cell Therapy and Immunology, Branch Potsdam IZI-BB, Am Muehlenberg 13, 14476 Potsdam, Germany., Pfisterer F; Fraunhofer Institute for Cell Therapy and Immunology, Branch Potsdam IZI-BB, Am Muehlenberg 13, 14476 Potsdam, Germany., Baumann W; Chair for Biophysics, University of Rostock, Gertrudenstr. 11a, 18057 Rostock, Germany., Bier FF; Fraunhofer Institute for Cell Therapy and Immunology, Branch Potsdam IZI-BB, Am Muehlenberg 13, 14476 Potsdam, Germany., Duschl C; Fraunhofer Institute for Cell Therapy and Immunology, Branch Potsdam IZI-BB, Am Muehlenberg 13, 14476 Potsdam, Germany., Kirschbaum M; Fraunhofer Institute for Cell Therapy and Immunology, Branch Potsdam IZI-BB, Am Muehlenberg 13, 14476 Potsdam, Germany.

Publikováno v: ACS applied bio materials [ACS Appl Bio Mater] 2019 Jul 15; Vol. 2 (7), pp. 2853-2861. Date of Electronic Publication: 2019 Jun 11.

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

Autor: Grauel MK; Institute of Neurophysiology, Charité Universitätsmedizin, 10117 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Institute of Biology, Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany., Maglione M; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Institute of Biology, Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany; Department of Molecular Pharmacology and Cell Biology, Leibniz Institut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany., Reddy-Alla S; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Institute of Biology, Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany., Willmes CG; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Institute of Biochemistry, Charité Universitätsmedizin, 10117 Berlin, Germany; Neuroscience Research Center (NWFZ), Charité Universitätsmedizin, 10117 Berlin, Germany., Brockmann MM; Institute of Neurophysiology, Charité Universitätsmedizin, 10117 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany., Trimbuch T; Institute of Neurophysiology, Charité Universitätsmedizin, 10117 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany., Rosenmund T; Institute of Neurophysiology, Charité Universitätsmedizin, 10117 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany., Pangalos M; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Neuroscience Research Center (NWFZ), Charité Universitätsmedizin, 10117 Berlin, Germany., Vardar G; Institute of Neurophysiology, Charité Universitätsmedizin, 10117 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany., Stumpf A; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Neuroscience Research Center (NWFZ), Charité Universitätsmedizin, 10117 Berlin, Germany., Walter AM; Molecular and Theoretical Neuroscience, Leibniz-Institut für Molekulare Pharmakologie, 10117 Berlin, Germany., Rost BR; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Neuroscience Research Center (NWFZ), Charité Universitätsmedizin, 10117 Berlin, Germany; DZNE- German Center for Neurodegenerative Diseases, Charité Universitätsmedizin, 10117 Berlin, Germany., Eickholt BJ; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Institute of Biochemistry, Charité Universitätsmedizin, 10117 Berlin, Germany., Haucke V; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Department of Molecular Pharmacology and Cell Biology, Leibniz Institut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany; Institute of Chemistry and Biochemistry, Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany., Schmitz D; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Neuroscience Research Center (NWFZ), Charité Universitätsmedizin, 10117 Berlin, Germany; DZNE- German Center for Neurodegenerative Diseases, Charité Universitätsmedizin, 10117 Berlin, Germany; christian.rosenmund@charite.de dietmar.schmitz@charite.de stephan.sigrist@fu-berlin.de., Sigrist SJ; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Institute of Biology, Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany; christian.rosenmund@charite.de dietmar.schmitz@charite.de stephan.sigrist@fu-berlin.de., Rosenmund C; Institute of Neurophysiology, Charité Universitätsmedizin, 10117 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; christian.rosenmund@charite.de dietmar.schmitz@charite.de stephan.sigrist@fu-berlin.de.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Oct 11; Vol. 113 (41), pp. 11615-11620. Date of Electronic Publication: 2016 Sep 26.

Duration of the unconditioned stimulus in appetitive conditioning of honeybees differentially impacts learning, long-term memory strength, and the underlying protein synthesis.

Autor: Marter K; Freie Universität Berlin, FB Biologie, Chemie, Pharmazie, Institut für Biologie, Neurobiologie, 14195 Berlin, Germany., Grauel MK; Freie Universität Berlin, FB Biologie, Chemie, Pharmazie, Institut für Biologie, Neurobiologie, 14195 Berlin, Germany., Lewa C; Freie Universität Berlin, FB Biologie, Chemie, Pharmazie, Institut für Biologie, Neurobiologie, 14195 Berlin, Germany., Morgenstern L; Freie Universität Berlin, FB Biologie, Chemie, Pharmazie, Institut für Biologie, Neurobiologie, 14195 Berlin, Germany., Buckemüller C; Freie Universität Berlin, FB Biologie, Chemie, Pharmazie, Institut für Biologie, Neurobiologie, 14195 Berlin, Germany., Heufelder K; Freie Universität Berlin, FB Biologie, Chemie, Pharmazie, Institut für Biologie, Neurobiologie, 14195 Berlin, Germany., Ganz M; Freie Universität Berlin, FB Biologie, Chemie, Pharmazie, Institut für Biologie, Neurobiologie, 14195 Berlin, Germany., Eisenhardt D; Freie Universität Berlin, FB Biologie, Chemie, Pharmazie, Institut für Biologie, Neurobiologie, 14195 Berlin, Germany dorothea.eisenhardt@fu-berlin.de.

Publikováno v: Learning & memory (Cold Spring Harbor, N.Y.) [Learn Mem] 2014 Nov 17; Vol. 21 (12), pp. 676-85. Date of Electronic Publication: 2014 Nov 17 (Print Publication: 2014).