Application of Monolayer Graphene to Cryo-Electron Microscopy Grids for High-resolution Structure Determination.

Autor: Grassetti AV; Department of Biology, Massachusetts Institute of Technology., May MB; Department of Biology, Massachusetts Institute of Technology., Davis JH; Department of Biology, Massachusetts Institute of Technology; Program in Computational and Systems Biology, Massachusetts Institute of Technology; jhdavis@mit.edu.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2023 Nov 10 (201). Date of Electronic Publication: 2023 Nov 10.

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.

Autor: Krajewska M; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA., Dries R; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.; Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Grassetti AV; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, USA., Dust S; Institute of Structural Biology, University of Bonn, 53127, Bonn, Germany., Gao Y; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA., Huang H; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA., Sharma B; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA., Day DS; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA., Kwiatkowski N; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Pomaville M; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA., Dodd O; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA., Chipumuro E; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA., Zhang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Greenleaf AL; Department of Biochemistry, Duke University Medical Center, Durham, NC, 27710, USA., Yuan GC; Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Harvard School of Public Health, Boston, MA, 02115, USA., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Young RA; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA., Geyer M; Institute of Structural Biology, University of Bonn, 53127, Bonn, Germany., Gerber SA; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, USA., George RE; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, 02115, USA. Rani_George@dfci.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA. Rani_George@dfci.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2019 Apr 15; Vol. 10 (1), pp. 1757. Date of Electronic Publication: 2019 Apr 15.

Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.

Autor: Zhao Y; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A., Cushing PR; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A.; PRC, LakePharma, Worcester, MA, U.S.A., Smithson DC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, U.S.A.; DCS, Genentech, South San Francisco, CA, U.S.A., Pellegrini M; Department of Chemistry, Dartmouth College, Hanover, NH 03755, U.S.A., Pletnev AA; Department of Chemistry, Dartmouth College, Hanover, NH 03755, U.S.A., Al-Ayyoubi S; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A.; SAA, Navigant, New York City, NY, U.S.A., Grassetti AV; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A., Gerber SA; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A., Guy RK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, U.S.A.; RKG, School of Pharmacy, University of Kentucky, Lexington, KY, U.S.A., Madden DR; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A. drm0001@dartmouth.edu.

Publikováno v: Bioscience reports [Biosci Rep] 2018 Jul 06; Vol. 38 (4). Date of Electronic Publication: 2018 Jul 06 (Print Publication: 2018).

Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis.

Autor: Johnson ME; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. michael.e.johnson@dartmouth.edu., Grassetti AV; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. andrew.v.grassetti.gr@dartmouth.edu., Taroni JN; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. jaclyn.n.taroni.gr@dartmouth.edu., Lyons SM; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA. smlyons@partners.org., Schweppe D; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. dkschwep@uw.edu., Gordon JK; Department of Rheumatology, Hospital for Special Surgery, New York, NY, USA. gordonj@hss.edu., Spiera RF; Department of Rheumatology, Hospital for Special Surgery, New York, NY, USA. spierar@hss.edu., Lafyatis R; Boston University School of Medicine, Boston, MA, USA. rlafyatis@gmail.com., Anderson PJ; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA. panderson@rics.bwh.harvard.edu., Gerber SA; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. scott.a.gerber@dartmouth.edu., Whitfield ML; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. michael.l.whitfield@dartmouth.edu.; Dartmouth Medical School, Hinman Box 7400, Hanover, NH, 03755, USA. michael.l.whitfield@dartmouth.edu.

Publikováno v: Arthritis research & therapy [Arthritis Res Ther] 2016 Jan 22; Vol. 18, pp. 27. Date of Electronic Publication: 2016 Jan 22.