Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

Autor: Joseph M. Salvino, Mohammed Fs, Khokhar I, Katerina Dukleska, Jordan M. Winter, Getts R, Brody, Prendergast E, Ilya Bederman, Hajhassani O, Browers J, Mahsa Zarei, Ali Vaziri-Gohar, Atheir I. Abbas, Joel Cassel, Jonathan J. Hue, Graor Hj, Rothermel Ld, Henri Brunengraber, Rui Wang, Chen

Pancreatic cancer cells alter their metabolism to survive cancer-associated stress (1-4). For example, cancer cells must adapt to steep nutrient gradients that characterize the natural tumor microenvironment (TME) (5-7). In the absence of adaptive st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64a609fef48b62d0bdc1530daadb2388
https://doi.org/10.1101/2020.11.19.390633

Therapeutic implications of the metabolic changes associated with BRAF inhibition in melanoma.

Autor: Loftus AW; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH 44106, USA., Zarei M; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Kakish H; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH 44106, USA., Hajihassani O; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Hue JJ; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH 44106, USA., Boutros C; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH 44106, USA., Graor HJ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Nakazzi F; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Bahlibi T; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Winter JM; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Rothermel LD; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. Electronic address: Luke.Rothermel@UHHospitals.org.

Publikováno v: Cancer treatment reviews [Cancer Treat Rev] 2024 Sep; Vol. 129, pp. 102795. Date of Electronic Publication: 2024 Jun 28.

Targeting wild-type IDH1 enhances chemosensitivity in pancreatic cancer.

Autor: Zarei M; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH.; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH., Hajihassani O; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH., Hue JJ; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH., Graor HJ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH., Rothermel LD; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH.; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH., Winter JM; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH.; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 29. Date of Electronic Publication: 2023 Mar 29.

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma.

Autor: Zarei M; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA., Hajihassani O; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Hue JJ; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA., Graor HJ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Loftus AW; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA., Rathore M; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Vaziri-Gohar A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Asara JM; Division of Signal Transduction and Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Winter JM; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. Jordan.Winter@UHHospitals.org.; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA. Jordan.Winter@UHHospitals.org., Rothermel LD; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. Luke.Rothermel@UHHospitals.org.; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA. Luke.Rothermel@UHHospitals.org.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Sep 24; Vol. 41 (1), pp. 283. Date of Electronic Publication: 2022 Sep 24.

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors.

Autor: Vaziri-Gohar A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Cassel J; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Mohammed FS; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Zarei M; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA., Hue JJ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA., Hajihassani O; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Graor HJ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Srikanth YVV; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Karim SA; Cancer Research UK Beatson Institute, Glasgow, UK., Abbas A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Prendergast E; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Chen V; Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA., Katayama ES; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Dukleska K; Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Khokhar I; Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Andren A; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA., Zhang L; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA., Wu C; Department of Radiology, Case Western Reserve University, Cleveland, OH, USA., Erokwu B; Department of Radiology, Case Western Reserve University, Cleveland, OH, USA., Flask CA; Deptartments of Radiology, Biomedical Engineering, and Pediatrics, Case Western Reserve University, Cleveland, OH, USA., Zarei M; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA., Wang R; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Rothermel LD; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA., Romani AMP; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA., Bowers J; Code Biotherapeutics Inc, Hatfield, PA, USA., Getts R; Code Biotherapeutics Inc, Hatfield, PA, USA., Tatsuoka C; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Morton JP; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Bederman I; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Brunengraber H; Department of Nutrition and Biochemistry, Case Western Reserve University, Cleveland, OH, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA., Salvino JM; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Brody JR; Brenden Colson Center for Pancreatic Care; Departments of Surgery and Cell, Developmental & Cancer Biology; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Winter JM; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. jordan.winter@UHhospitals.org.; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA. jordan.winter@UHhospitals.org.

Publikováno v: Nature cancer [Nat Cancer] 2022 Jul; Vol. 3 (7), pp. 852-865. Date of Electronic Publication: 2022 Jun 09.