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pro vyhledávání: '"Granzyme H"'
Akademický článek
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Akademický článek
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Autor:
Yutaka Enomoto, Markus Hafner, Lisa M. Miller Jenkins, Gaelyn C. Lyons, Dimitrios G. Anastasakis, Warren J. Leonard, Peng Li
Publikováno v:
Cancer Gene Therapy. 29:734-749
Natural killer (NK) cells play key roles in immune surveillance against tumors and viral infection. NK cells distinguish abnormal cells from healthy cells by cell–cell interaction with cell surface proteins and then attack target cells via multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc2190b4d926ce85bc31df918109af7
https://doi.org/10.1038/s41417-021-00352-2
https://doi.org/10.1038/s41417-021-00352-2
Autor:
Bingjun Zhang, Tingting Lu, Zhengqi Lu, Lei Wei, Danli Lu, Bing Qin, Mengyan Hu, Aimin Wu, Dafan Yu, Xiaodong Chen, Wei Cai
Background: Circulating natural killer cells (NK cells) are enriched in the central nervous system in atheriosclerotic cerebral small vessel disease (aCSVD) rat models, but their resulting effects and underlying mechanism remain to be investigated.Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a7e0182c4e8bf3e5419e8969de57a04
https://doi.org/10.21203/rs.3.rs-686525/v1
https://doi.org/10.21203/rs.3.rs-686525/v1
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-7 (2019)
BMC Research Notes
BMC Research Notes
Objective To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b368cf92681904e0a11470cf06bdb36
http://link.springer.com/article/10.1186/s13104-019-4237-9
http://link.springer.com/article/10.1186/s13104-019-4237-9
Autor:
Brownlie, Demi, Scharenberg, Marlena, Mold, Jeff E., Hard, Joanna, Kekäläinen, Eliisa, Buggert, Marcus, Nguyen, Son, Wilson, Jennifer N., Al-Ameri, Mamdoh, Ljunggren, Hans-Gustaf, Marquardt, Nicole, Michaelsson, Jakob
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Respiratory diseases are leading causes of death worldwide. However, the local immune cell composition in the human lung and individual outliers within the population still remain largely undescribed. We here identify adaptive-like NK ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b6633b29cfbfea292de1680394187490
https://pubmed.ncbi.nlm.nih.gov/33836578
https://pubmed.ncbi.nlm.nih.gov/33836578
Autor:
Yunpeng Yang, Yang Zhang, Hua Bao, Xue Wu, Wanxiangfu Tang, Shaodong Hong, Wenfeng Fang, Ao Wang, Yang Shao, Li Zhang, Yan Huang, Qingguang Lin, Yuxiang Ma, Hongyun Zhao, Xi Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundAnti-programmed death (PD)-1 therapy has recently been used in recurrent or metastatic (R/M) nasopharyngeal carcinoma (NPC). The long-term survival and its biomarkers responding to anti-PD-1 treatment in patients with R/M NPC remain unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e933c8331f27c24226e77838695cf3
https://jitc.bmj.com/content/9/3/e002014.full
https://jitc.bmj.com/content/9/3/e002014.full
Autor:
Ryan Geschwindt, Thomas B. Karasic, Kevin O’Hayer, Susan Spitz, Johanna C. Bendell, Solmaz Sahebjam, Janice M. Mehnert, Tara C. Mitchell, Hao Liu, Sarina Anne Piha-Paul
Publikováno v:
Regular and young investigator award abstracts.
Background Pharmacological blockade of the PD-1:PD-L1 interaction with monoclonal antibodies (mAbs) has shown durable clinical responses and overall survival benefit in a variety of malignancies.1 2 Importantly, the most meaningful responses have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3116986116f398aa856638cc42a21f7
https://doi.org/10.1136/jitc-2020-sitc2020.0419
https://doi.org/10.1136/jitc-2020-sitc2020.0419
Autor:
David Malone, Maxi Heyner, Frank Klawonn, Edwin Leeansyah, Lothar Jänsch, Johan K. Sandberg, Niklas K. Björkström, Lothar Gröbe, Hans-Gustaf Ljunggren, Jenny Voigt, Joana Dias
Publikováno v:
European Journal of Immunology. 48:1456-1469
NK cells lacking CD56 (CD56neg ) were first identified in chronic HIV-1 infection. However, CD56neg NK cells also exist in healthy individuals, albeit in significantly lower numbers. Here, we provide an extensive proteomic characterisation of human C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6646d132146ef38e3c646086fcb2c3c1
https://doi.org/10.1002/eji.201747450
https://doi.org/10.1002/eji.201747450
Publikováno v:
Journal of Molecular Graphics and Modelling. 105:107876
Granzymes are serine proteases synthesized by CTL and NK cells. Five granzyme genes (GzmA, -B, -H, -K, -M) are present in humans, which are located at three different chromosomal loci. Being serine proteases, the binding pocket constitutes a catalyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802bfc84b600b30cd89e4ca7a2cfde84
https://doi.org/10.1016/j.jmgm.2021.107876
https://doi.org/10.1016/j.jmgm.2021.107876